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• W4280568518 abstract "Mammalian target of rapamycin complex 1 (mTORC1) senses amino acids to control cell growth, metabolism, and autophagy. Some amino acids signal to mTORC1 through the Rag GTPase, whereas glutamine and asparagine activate mTORC1 through a Rag GTPase-independent pathway. Here, we show that the lysosomal glutamine and asparagine transporter SNAT7 activates mTORC1 after extracellular protein, such as albumin, is macropinocytosed. The N terminus of SNAT7 forms nutrient-sensitive interaction with mTORC1 and regulates mTORC1 activation independently of the Rag GTPases. Depletion of SNAT7 inhibits albumin-induced mTORC1 lysosomal localization and subsequent activation. Moreover, SNAT7 is essential to sustain KRAS-driven pancreatic cancer cell growth through mTORC1. Thus, SNAT7 links glutamine and asparagine signaling from extracellular protein to mTORC1 independently of the Rag GTPases and is required for macropinocytosis-mediated mTORC1 activation and pancreatic cancer cell growth." @default.
• W4280568518 created "2022-05-22" @default.
• W4280568518 creator A5009364457 @default.
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• W4280568518 creator A5088103696 @default.
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• W4280568518 creator A5048521079 @default.
• W4280568518 date "2022-05-13" @default.
• W4280568518 modified "2023-10-01" @default.
• W4280568518 title "SNAT7 regulates mTORC1 via macropinocytosis" @default.
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