FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4280580333> ?p ?o ?g. }

• W4280580333 endingPage "147949" @default.
• W4280580333 startingPage "147949" @default.
• W4280580333 abstract "We investigated the effects of dexmedetomidine, a selective α2-adrenergic agonist and a sedative, on excessive glutamate-induced depressions of central excitatory synaptic transmissions in vitro. From the CA1 in rat hippocampal slices, orthodromically elicited population spikes (PSs) and field excitatory postsynaptic potentials (fEPSPs) at 0.1 Hz were simultaneously recorded. ANOVA was used for statistics, and p < 0.05 was accepted as significant. Glutamate (10 mM for 10 min) completely depressed PSs and fEPSPs, which were partially recovered by the following washout for 40 min (57.4 ± 10.2% and 59.9 ± 9.8% of the control, respectively, p < 0.01, n = 6). The recoveries in PSs and fEPSPs were improved by pre-treatment and simultaneous treatment with dexmedetomidine (p < 0.01, n = 6) but were not altered by post-treatment. Dexmedetomidine alone did not alter PSs and fEPSPs. Simultaneous treatment with isoproterenol or dobutamine exacerbated the recoveries in PSs and fEPSPs (p < 0.01, n = 6), but simultaneous treatment with salbutamol, propranolol, phenylephrine or phentramine did not influence the recoveries. Simultaneous treatment with AP5 improved the recoveries in PSs and fEPSPs that were depressed by glutamate alone and by glutamate with dexmedetomidine, isoproterenol or dobutamine (p < 0.01, n = 6). Excessive glutamate depresses glutamatergic excitatory synaptic transmissions by mainly mediating NMDA receptors, and the depressed transmissions are improved by α2-adrenoceptor stimulation but are exacerbated by β1-adrenoceptor stimulation. Dexmedetomidine has a protective effect on neuronal dysfunctions induced by excessive glutamate, which is one of the main mechanisms of the secondary damage in the central nervous system." @default.
• W4280580333 created "2022-05-22" @default.
• W4280580333 creator A5004891652 @default.
• W4280580333 creator A5006679582 @default.
• W4280580333 creator A5012945526 @default.
• W4280580333 creator A5043039742 @default.
• W4280580333 creator A5046555318 @default.
• W4280580333 creator A5058685528 @default.
• W4280580333 creator A5088399380 @default.
• W4280580333 date "2022-08-01" @default.
• W4280580333 modified "2023-09-27" @default.
• W4280580333 title "Dexmedetomidine improves excessive extracellular glutamate-induced synaptic depression (BRAINRES-D-21-00941)" @default.
• W4280580333 cites W1423528220 @default.
• W4280580333 cites W1579083749 @default.
• W4280580333 cites W1596299456 @default.
• W4280580333 cites W1970601346 @default.
• W4280580333 cites W1975739213 @default.
• W4280580333 cites W1976172889 @default.
• W4280580333 cites W1984398032 @default.
• W4280580333 cites W1985220401 @default.
• W4280580333 cites W1993783741 @default.
• W4280580333 cites W2023959801 @default.
• W4280580333 cites W2028490177 @default.
• W4280580333 cites W2038364320 @default.
• W4280580333 cites W2048841941 @default.
• W4280580333 cites W2050662632 @default.
• W4280580333 cites W2053147519 @default.
• W4280580333 cites W2060192065 @default.
• W4280580333 cites W2067220253 @default.
• W4280580333 cites W2071955212 @default.
• W4280580333 cites W2086615573 @default.
• W4280580333 cites W2089146116 @default.
• W4280580333 cites W2097293665 @default.
• W4280580333 cites W2123932602 @default.
• W4280580333 cites W2137136023 @default.
• W4280580333 cites W2145948868 @default.
• W4280580333 cites W2161205313 @default.
• W4280580333 cites W2261425654 @default.
• W4280580333 cites W2606781935 @default.
• W4280580333 cites W2616329892 @default.
• W4280580333 cites W2805472034 @default.
• W4280580333 cites W2899433146 @default.
• W4280580333 cites W2915980011 @default.
• W4280580333 cites W2924277113 @default.
• W4280580333 cites W2951048045 @default.
• W4280580333 cites W2989662007 @default.
• W4280580333 cites W4246612811 @default.
• W4280580333 doi "https://doi.org/10.1016/j.brainres.2022.147949" @default.
• W4280580333 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35598640" @default.
• W4280580333 hasPublicationYear "2022" @default.
• W4280580333 type Work @default.
• W4280580333 citedByCount "0" @default.
• W4280580333 crossrefType "journal-article" @default.
• W4280580333 hasAuthorship W4280580333A5004891652 @default.
• W4280580333 hasAuthorship W4280580333A5006679582 @default.
• W4280580333 hasAuthorship W4280580333A5012945526 @default.
• W4280580333 hasAuthorship W4280580333A5043039742 @default.
• W4280580333 hasAuthorship W4280580333A5046555318 @default.
• W4280580333 hasAuthorship W4280580333A5058685528 @default.
• W4280580333 hasAuthorship W4280580333A5088399380 @default.
• W4280580333 hasConcept C112592302 @default.
• W4280580333 hasConcept C126322002 @default.
• W4280580333 hasConcept C170493617 @default.
• W4280580333 hasConcept C17077164 @default.
• W4280580333 hasConcept C185592680 @default.
• W4280580333 hasConcept C200170125 @default.
• W4280580333 hasConcept C2776814716 @default.
• W4280580333 hasConcept C2778938600 @default.
• W4280580333 hasConcept C2780648746 @default.
• W4280580333 hasConcept C2781302539 @default.
• W4280580333 hasConcept C42219234 @default.
• W4280580333 hasConcept C61174792 @default.
• W4280580333 hasConcept C67018056 @default.
• W4280580333 hasConcept C71924100 @default.
• W4280580333 hasConcept C98274493 @default.
• W4280580333 hasConceptScore W4280580333C112592302 @default.
• W4280580333 hasConceptScore W4280580333C126322002 @default.
• W4280580333 hasConceptScore W4280580333C170493617 @default.
• W4280580333 hasConceptScore W4280580333C17077164 @default.
• W4280580333 hasConceptScore W4280580333C185592680 @default.
• W4280580333 hasConceptScore W4280580333C200170125 @default.
• W4280580333 hasConceptScore W4280580333C2776814716 @default.
• W4280580333 hasConceptScore W4280580333C2778938600 @default.
• W4280580333 hasConceptScore W4280580333C2780648746 @default.
• W4280580333 hasConceptScore W4280580333C2781302539 @default.
• W4280580333 hasConceptScore W4280580333C42219234 @default.
• W4280580333 hasConceptScore W4280580333C61174792 @default.
• W4280580333 hasConceptScore W4280580333C67018056 @default.
• W4280580333 hasConceptScore W4280580333C71924100 @default.
• W4280580333 hasConceptScore W4280580333C98274493 @default.
• W4280580333 hasFunder F4320334764 @default.
• W4280580333 hasLocation W42805803331 @default.
• W4280580333 hasLocation W42805803332 @default.
• W4280580333 hasOpenAccess W4280580333 @default.
• W4280580333 hasPrimaryLocation W42805803331 @default.
• W4280580333 hasRelatedWork W1982479994 @default.
• W4280580333 hasRelatedWork W1984064153 @default.
• W4280580333 hasRelatedWork W1987085388 @default.

• next