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• W4280583273 abstract "Gonadal hormone is essential for the health of postmenopausal women, however, few studies have focused on the epidemiological distribution of gonadal hormones in postmenopausal women in very late postmenopausal women. This study aims to investigate and analyze the differences of serum gonadal hormone content and its influential factors among female centenarians in Hainan, China.The questionnaire and physical examination data of 741 female centenarians and 401 elderly females in Hainan Province were collected, and venous blood samples were taken to detect the indexes of lipid metabolism, bone metabolism, and gonadal hormone. The differences of gonadal hormones and relavant factors in female centenarians were analyzed and compared.The serum levels of estradiol and progesterone of female centenarians were significantly higher than those of the elderly females (both P<0.001). The serum levels of estradiol and testosterone of ethnic minority centenarians were higher than those in Han nationality (P<0.001), and the serum estradiol and testosterone concentrations were relatively higher when the daily activities were more than 10 min (both P<0.05). Serum estradiol concentration was negatively correlated with apolipoprotein A-I, high density lipoprotein, triglyceride and bone formation markers such as calcium, inorganic phosphorus and vitamin D3, and was positively correlated with the special sequence of β-collagen (markers of bone resorption) (all P<0.01).For the extremely late postmenopausal women (such as centenarians), there may be characteristic expressions of gonadal hormones, especially estradiol. There is an unprotective correlation of serum estradiol with lipid metabolism index and bone metabolism index in female centenarians, so it is necessary to evaluate the estrogen content and the use of estrogen therapy in postmenopausal women.目的: 性腺激素对于绝经后女性健康至关重要，然而，很少有研究集中于绝经后超晚期女性老人性腺激素的流行病学分布。本研究调查并分析海南地区百岁女性老人血清性腺激素含量差异及其影响因素。方法: 收集海南741例百岁女性老人和401例高龄女性老人的调查问卷及体检资料，并检测其静脉血脂代谢、骨代谢及性腺激素等指标的水平。比较百岁女性老人性腺激素差异并分析其关联因素。结果: 百岁女性老人血清雌二醇、孕酮水平均显著高于高龄女性老人(均P<0.001)；文化程度高、生育子女数少者血清雌二醇水平增高(均P<0.01)；少数民族百岁老人血清孕酮水平高于汉族(P<0.001)；每日持续活动10 min以上者血清雌二醇、睾酮水平均相对高于每日持续活动<10 min者(均P<0.05)；血清雌二醇水平与载脂蛋白A-I、高密度脂蛋白、三酰甘油等脂代谢指标呈负相关；与钙、无机磷、维生素D3等骨形成标志物呈负相关，与β-胶原特殊序列(骨吸收标志物)呈正相关(均P<0.01)。结论: 对于绝经后极晚期的女性人群(如百岁老人)，性腺激素尤其是雌二醇可能存在特征性表达。百岁女性老人血清雌二醇水平与脂代谢、骨代谢指标存在非保护性的关联关系，有必要对绝经后极晚期女性的雌激素水平及雌激素疗法的使用作深入评估。." @default.
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• W4280583273 date "2022-01-28" @default.
• W4280583273 modified "2023-10-16" @default.
• W4280583273 title "Cross-sectional analysis of gonadal hormone expression and relevant factors in female centenarians in Hainan, China." @default.
• W4280583273 doi "https://doi.org/10.11817/j.issn.1672-7347.2022.210079" @default.
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