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• W4280587852 abstract "Thermal ablation is a well-established successful treatment for cardiac arrhythmia, but it still presents limitations that require further studies and developments. In the rotor-driven functional re-entry arrhythmia, tissue heterogeneity results on the generation of spiral/scroll waves and wave break dynamics that may cause dangerous sustainable fibrillation. The selection of the target region to perform thermal ablation to mitigate this type of arrhythmia is challenging, since it considerably affects the local electrophysiology dynamics. This work deals with the numerical simulation of the thermal ablation of a cardiac muscle tissue and its effects on the dynamics of rotor-driven functional re-entry arrhythmia. A non-homogeneous two-dimensional rectangular region is used in the present numerical analysis, where radiofrequency ablation is performed. The electrophysiology problem for the propagation of the action potential in the cardiac tissue is simulated with the Fenton-Karma model. Thermal damage caused to the tissue by the radiofrequency heating is modeled by the Arrhenius equation. The effects of size and position of a heterogeneous region in the original muscle tissue were first analyzed, in order to verify the possible existence of the functional re-entry arrhythmia during the time period considered in the simulations. For each case that exhibited re-entry arrhythmia, six different ablation procedures were analyzed, depending on the position of the radiofrequency electrode and heating time. The obtained results revealed the effects of different model parameters on the existence and possible mitigation of the functional re-entry arrhythmia." @default.
• W4280587852 created "2022-05-22" @default.
• W4280587852 creator A5022536912 @default.
• W4280587852 creator A5052489314 @default.
• W4280587852 creator A5064384135 @default.
• W4280587852 date "2022-05-27" @default.
• W4280587852 modified "2023-09-26" @default.
• W4280587852 title "Thermal ablation effects on rotors that characterize functional re‐entry cardiac arrhythmia" @default.
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• W4280587852 doi "https://doi.org/10.1002/cnm.3614" @default.
• W4280587852 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35543287" @default.
• W4280587852 hasPublicationYear "2022" @default.
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