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• W4280590520 abstract "Abstract Intracellular bacteria such as the pathogen Coxiella burnetii inject effector proteins into the host cell that promote productive infection. One common strategy of pathogen effectors is to suppress host immune responses to enable pathogen replication. The C. burnetii type IV secretion system translocates a large number of effectors into host cells that collectively promote intracellular bacterial replication, but the individual functions of most of these effectors are poorly understood. In this study, we describe a C. burnetii effector, CBU1314, that localizes to the nucleus and inhibits NF-κB-, MAPK-, and type I IFN-dependent gene expression. Mechanistically, we find that CBU1314 interacts with the PAF1 complex (PAF1C), a central host transcriptional complex that regulates expression of inflammatory genes in innate immune cells. Notably, we find that PAF1 promotes immune gene expression in response to various immune agonists and C. burnetii infection. Moreover, we find that PAF1 is critical for restricting intracellular C. burnetii replication. Overall, our findings uncover PAF1C as a host target of a C. burnetii effector and reveal new insight into how intracellular bacterial pathogens subvert cell- intrinsic innate defenses. Significance Intracellular bacteria often employ secreted effector proteins to modulate cellular processes and survive intracellularly. The study of these effectors can provide valuable insight into microbial pathogenesis and host biology. Here, we describe a Coxiella burnetii effector that inhibits multiple host signaling pathways and modulates the innate immune response. This effector interacts with the host PAF1 complex (PAF1C), a central regulator of transcription. Furthermore, we show that PAF1 is necessary for maximal gene expression downstream of various innate immune receptors and restricts bacterial replication during infection. Overall, our study elucidates the function of a C. burnetii effector in evading the immune response and provides insight into the role of PAF1C in cell-intrinsic defense against bacterial pathogens." @default.
• W4280590520 created "2022-05-22" @default.
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• W4280590520 date "2022-04-26" @default.
• W4280590520 modified "2023-09-29" @default.
• W4280590520 title "A <i>Coxiella burnetii</i> effector interacts with the host PAF1 complex and suppresses the innate immune response" @default.
• W4280590520 cites W1485859054 @default.
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• W4280590520 cites W1541003372 @default.
• W4280590520 cites W160238758 @default.
• W4280590520 cites W1972169896 @default.
• W4280590520 cites W1975556592 @default.
• W4280590520 cites W1978555334 @default.
• W4280590520 cites W1979404155 @default.
• W4280590520 cites W1987800549 @default.
• W4280590520 cites W1994942139 @default.
• W4280590520 cites W1997657977 @default.
• W4280590520 cites W2022044675 @default.
• W4280590520 cites W2028651845 @default.
• W4280590520 cites W2030197516 @default.
• W4280590520 cites W2030598858 @default.
• W4280590520 cites W2051889688 @default.
• W4280590520 cites W2061953258 @default.
• W4280590520 cites W2062418171 @default.
• W4280590520 cites W2066113694 @default.
• W4280590520 cites W2073240850 @default.
• W4280590520 cites W2078844752 @default.
• W4280590520 cites W2080274549 @default.
• W4280590520 cites W2080594285 @default.
• W4280590520 cites W2090154299 @default.
• W4280590520 cites W2090591701 @default.
• W4280590520 cites W2095395800 @default.
• W4280590520 cites W2097137881 @default.
• W4280590520 cites W2097298997 @default.
• W4280590520 cites W2106296224 @default.
• W4280590520 cites W2109122955 @default.
• W4280590520 cites W2112502431 @default.
• W4280590520 cites W2114216755 @default.
• W4280590520 cites W2124034233 @default.
• W4280590520 cites W2124371255 @default.
• W4280590520 cites W2125445370 @default.
• W4280590520 cites W2132815922 @default.
• W4280590520 cites W2133449490 @default.
• W4280590520 cites W2134903749 @default.
• W4280590520 cites W2157942810 @default.
• W4280590520 cites W2158949802 @default.
• W4280590520 cites W2162832155 @default.
• W4280590520 cites W2171772350 @default.
• W4280590520 cites W2193525073 @default.
• W4280590520 cites W2211150216 @default.
• W4280590520 cites W2235949282 @default.
• W4280590520 cites W2237816067 @default.
• W4280590520 cites W2261652338 @default.
• W4280590520 cites W2270624586 @default.
• W4280590520 cites W2274233097 @default.
• W4280590520 cites W2288359781 @default.
• W4280590520 cites W2300735552 @default.
• W4280590520 cites W2310302308 @default.
• W4280590520 cites W2333803484 @default.
• W4280590520 cites W2443329401 @default.
• W4280590520 cites W2460472689 @default.
• W4280590520 cites W2463195069 @default.
• W4280590520 cites W2519256061 @default.
• W4280590520 cites W2544360569 @default.
• W4280590520 cites W2566732703 @default.
• W4280590520 cites W2805170482 @default.
• W4280590520 cites W2810614133 @default.
• W4280590520 cites W2887794053 @default.
• W4280590520 cites W2904824676 @default.
• W4280590520 cites W2919760852 @default.
• W4280590520 cites W2926691411 @default.
• W4280590520 cites W2947763143 @default.
• W4280590520 cites W2955819370 @default.
• W4280590520 cites W2995270543 @default.
• W4280590520 cites W3029372005 @default.
• W4280590520 cites W3147357211 @default.
• W4280590520 cites W3213821873 @default.
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• W4280590520 doi "https://doi.org/10.1101/2022.04.20.488957" @default.
• W4280590520 hasPublicationYear "2022" @default.
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