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• W4280590779 abstract "<h2>Abstract</h2> The clinical progression of the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) to critical illness is associated with a systemic and uncontrolled inflammatory response of the innate and adaptive immunity with the release of a plethora of proinflammatory cytokines termed cytokine storm. In the absence of an effective treatment, many off-label agents from the armamentarium of rheumatology are used. Here, from the perspective of a rheumatologist, we will discuss the current therapeutic strategies in critically ill patients with SARS-CoV-2 pneumonia. Thus, we will discuss the agents that aim to target viral entry and its replication into the host cell and those focusing and targeting the inflammatory response. In this setting, many agents have been used with promising results but, not all have been approved by the International Authorities and Institutions. In the first step (viral entry), SARS-CoV-2 monoclonal antibodies and remdesivir have been approved to be used and, in the second step, corticosteroids along with interleukin-6 inhibitors, or Janus Kinase inhibitors are currently used." @default.
• W4280590779 created "2022-05-22" @default.
• W4280590779 creator A5002536319 @default.
• W4280590779 creator A5053973975 @default.
• W4280590779 creator A5054058404 @default.
• W4280590779 date "2022-08-01" @default.
• W4280590779 modified "2023-10-14" @default.
• W4280590779 title "Treatment strategies of COVID-19: A rheumatology perspective" @default.
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• W4280590779 doi "https://doi.org/10.1016/j.ejim.2022.05.014" @default.
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