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• W4280597954 abstract "Pregnancy is energetically demanding and therefore, by necessity, reproduction and energy balance are inextricably linked. With insufficient or excessive energy stores a female is liable to suffer complications during pregnancy or produce unhealthy offspring. Gonadotropin-releasing hormone neurons are responsible for initiating both the pulsatile and subsequent surge release of luteinizing hormone to control ovulation. Meticulous work has identified two hypothalamic populations of kisspeptin (Kiss1) neurons that are critical for this pattern of release. The involvement of the hypothalamus is unsurprising because its quintessential function is to couple the endocrine and nervous systems, coordinating energy balance and reproduction. Estrogens, more specifically 17β-estradiol (E2 ), orchestrate the activity of a triumvirate of hypothalamic neurons within the arcuate nucleus (ARH) that govern the physiological underpinnings of these behavioral dynamics. Arising from a common progenitor pool, these cells differentiate into ARH kisspeptin, pro-opiomelanocortin (POMC), and agouti related peptide/neuropeptide Y (AgRP) neurons. Although the excitability of all these subpopulations is subject to genomic and rapid estrogenic regulation, Kiss1 neurons are the most sensitive, reflecting their integral function in female fertility. Based on the premise that E2 coordinates autonomic functions around reproduction, we review recent findings on how Kiss1 neurons interact with gonadotropin-releasing hormone, AgRP and POMC neurons, as well as how the rapid membrane-initiated and intracellular signaling cascades activated by E2 in these neurons are critical for control of homeostatic functions supporting reproduction. In particular, we highlight how Kiss1 and POMC neurons conspire to inhibit AgRP neurons and diminish food motivation in service of reproductive success." @default.
• W4280597954 created "2022-05-22" @default.
• W4280597954 creator A5059656260 @default.
• W4280597954 creator A5080065013 @default.
• W4280597954 date "2022-05-17" @default.
• W4280597954 modified "2023-10-17" @default.
• W4280597954 title "Estrogenic regulation of reproduction and energy homeostasis by a triumvirate of hypothalamic arcuate neurons" @default.
• W4280597954 cites W1489541636 @default.
• W4280597954 cites W1495726008 @default.
• W4280597954 cites W1506453366 @default.
• W4280597954 cites W1553270649 @default.
• W4280597954 cites W1557591071 @default.
• W4280597954 cites W1561443084 @default.
• W4280597954 cites W1594452843 @default.
• W4280597954 cites W1614504110 @default.
• W4280597954 cites W1628473023 @default.
• W4280597954 cites W1795513906 @default.
• W4280597954 cites W1832803167 @default.
• W4280597954 cites W1893713587 @default.
• W4280597954 cites W1896220440 @default.
• W4280597954 cites W1960449411 @default.
• W4280597954 cites W1967450028 @default.
• W4280597954 cites W1967718477 @default.
• W4280597954 cites W1970076139 @default.
• W4280597954 cites W1971281111 @default.
• W4280597954 cites W1971359921 @default.
• W4280597954 cites W1971399893 @default.
• W4280597954 cites W1972038183 @default.
• W4280597954 cites W1972449685 @default.
• W4280597954 cites W1973359179 @default.
• W4280597954 cites W1974593629 @default.
• W4280597954 cites W1974743256 @default.
• W4280597954 cites W1975041168 @default.
• W4280597954 cites W1975832789 @default.
• W4280597954 cites W1975862819 @default.
• W4280597954 cites W1975890243 @default.
• W4280597954 cites W1975975612 @default.
• W4280597954 cites W1976772834 @default.
• W4280597954 cites W1977013546 @default.
• W4280597954 cites W1977698842 @default.
• W4280597954 cites W1978318213 @default.
• W4280597954 cites W1979634104 @default.
• W4280597954 cites W1980753298 @default.
• W4280597954 cites W1981378049 @default.
• W4280597954 cites W1981467972 @default.
• W4280597954 cites W1981897232 @default.
• W4280597954 cites W1982420534 @default.
• W4280597954 cites W1982630707 @default.
• W4280597954 cites W1982647461 @default.
• W4280597954 cites W1983046294 @default.
• W4280597954 cites W1983714777 @default.
• W4280597954 cites W1984836542 @default.
• W4280597954 cites W1985473949 @default.
• W4280597954 cites W1986938347 @default.
• W4280597954 cites W1988149499 @default.
• W4280597954 cites W1989698840 @default.
• W4280597954 cites W1990189709 @default.
• W4280597954 cites W1990341525 @default.
• W4280597954 cites W1990546536 @default.
• W4280597954 cites W1990876027 @default.
• W4280597954 cites W1991847642 @default.
• W4280597954 cites W1992041715 @default.
• W4280597954 cites W1992174470 @default.
• W4280597954 cites W1993840841 @default.
• W4280597954 cites W1995026750 @default.
• W4280597954 cites W1995765320 @default.
• W4280597954 cites W1996372562 @default.
• W4280597954 cites W1996382204 @default.
• W4280597954 cites W1996713062 @default.
• W4280597954 cites W1997404862 @default.
• W4280597954 cites W1998242092 @default.
• W4280597954 cites W1998286971 @default.
• W4280597954 cites W1998558312 @default.
• W4280597954 cites W1998794774 @default.
• W4280597954 cites W2002275574 @default.
• W4280597954 cites W2005121205 @default.
• W4280597954 cites W2005585033 @default.
• W4280597954 cites W2005998513 @default.
• W4280597954 cites W2006036568 @default.
• W4280597954 cites W2006727096 @default.
• W4280597954 cites W2007161557 @default.
• W4280597954 cites W2007963752 @default.
• W4280597954 cites W2009122075 @default.
• W4280597954 cites W2009302214 @default.
• W4280597954 cites W2009545143 @default.
• W4280597954 cites W2010920434 @default.
• W4280597954 cites W2010987536 @default.
• W4280597954 cites W2011348770 @default.
• W4280597954 cites W2012362306 @default.
• W4280597954 cites W2012425172 @default.
• W4280597954 cites W2012940628 @default.
• W4280597954 cites W2013814235 @default.
• W4280597954 cites W2013995127 @default.
• W4280597954 cites W2014093920 @default.
• W4280597954 cites W2014455593 @default.
• W4280597954 cites W2016233115 @default.
• W4280597954 cites W2019110947 @default.
• W4280597954 cites W2021454655 @default.
• W4280597954 cites W2021663501 @default.
• W4280597954 cites W2024067647 @default.

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