Matches in SemOpenAlex for { <https://semopenalex.org/work/W4280597972> ?p ?o ?g. }
- W4280597972 abstract "Intratumor microbiome shapes the immune system and influences the outcome of various tumors. Porphyromonas gingivalis (P. gingivalis), the keystone periodontal pathogen, is highly epidemically connected with pancreatic cancer (PC). However, its causative role and the underlining mechanism in promoting PC oncogenesis remain unclear. Here, we illustrated the landscape of intratumor microbiome and its bacterial correlation with oral cavity in PC patients, where P. gingivalis presented both in the oral cavity and tumor tissues. When exposed to P. gingivalis, tumor development was accelerated in orthotopic and subcutaneous PC mouse model, and the cancerous pancreas exhibited a neutrophils-dominated proinflammatory tumor microenvironment. Mechanistically, the intratumoral P. gingivalis promoted PC progression via elevating the secretion of neutrophilic chemokines and neutrophil elastase (NE). Collectively, our study disclosed the bacterial link between periodontitis and PC, and revealed a previously unrecognized mechanism of P. gingivalis in PC pathophysiology, hinting at therapeutic implications." @default.
- W4280597972 created "2022-05-22" @default.
- W4280597972 creator A5004906371 @default.
- W4280597972 creator A5013656851 @default.
- W4280597972 creator A5027136794 @default.
- W4280597972 creator A5046211215 @default.
- W4280597972 creator A5052880029 @default.
- W4280597972 creator A5053957639 @default.
- W4280597972 creator A5059065464 @default.
- W4280597972 creator A5065941887 @default.
- W4280597972 date "2022-05-12" @default.
- W4280597972 modified "2023-10-09" @default.
- W4280597972 title "Periodontitis pathogen <i>Porphyromonas gingivalis</i> promotes pancreatic tumorigenesis via neutrophil elastase from tumor-associated neutrophils" @default.
- W4280597972 cites W129563261 @default.
- W4280597972 cites W1567450894 @default.
- W4280597972 cites W1571823809 @default.
- W4280597972 cites W1985285110 @default.
- W4280597972 cites W1986316854 @default.
- W4280597972 cites W2050975242 @default.
- W4280597972 cites W2065858300 @default.
- W4280597972 cites W2073924079 @default.
- W4280597972 cites W2076881902 @default.
- W4280597972 cites W2096139589 @default.
- W4280597972 cites W2104996119 @default.
- W4280597972 cites W2109704767 @default.
- W4280597972 cites W2114929859 @default.
- W4280597972 cites W2117727921 @default.
- W4280597972 cites W2136246490 @default.
- W4280597972 cites W2157107905 @default.
- W4280597972 cites W2226708402 @default.
- W4280597972 cites W2306651097 @default.
- W4280597972 cites W2531011640 @default.
- W4280597972 cites W2567429266 @default.
- W4280597972 cites W2578607799 @default.
- W4280597972 cites W2580016946 @default.
- W4280597972 cites W2607672964 @default.
- W4280597972 cites W2618696573 @default.
- W4280597972 cites W2756403351 @default.
- W4280597972 cites W2769277374 @default.
- W4280597972 cites W2771173285 @default.
- W4280597972 cites W2781525129 @default.
- W4280597972 cites W2790589159 @default.
- W4280597972 cites W2795824476 @default.
- W4280597972 cites W2806666357 @default.
- W4280597972 cites W2894451493 @default.
- W4280597972 cites W2899467045 @default.
- W4280597972 cites W2900176156 @default.
- W4280597972 cites W2904548584 @default.
- W4280597972 cites W2908052958 @default.
- W4280597972 cites W2910596423 @default.
- W4280597972 cites W2912555658 @default.
- W4280597972 cites W2917919815 @default.
- W4280597972 cites W2924880215 @default.
- W4280597972 cites W2951616328 @default.
- W4280597972 cites W2952987391 @default.
- W4280597972 cites W2967450000 @default.
- W4280597972 cites W2971220345 @default.
- W4280597972 cites W2972734154 @default.
- W4280597972 cites W2993453774 @default.
- W4280597972 cites W2993667306 @default.
- W4280597972 cites W2996039207 @default.
- W4280597972 cites W3028823705 @default.
- W4280597972 cites W3030942202 @default.
- W4280597972 cites W3034318868 @default.
- W4280597972 cites W3044222890 @default.
- W4280597972 cites W3062502583 @default.
- W4280597972 cites W3106587030 @default.
- W4280597972 cites W3111470573 @default.
- W4280597972 cites W3136766980 @default.
- W4280597972 cites W3188775984 @default.
- W4280597972 cites W3215395566 @default.
- W4280597972 cites W4200344844 @default.
- W4280597972 cites W4200491533 @default.
- W4280597972 doi "https://doi.org/10.1080/19490976.2022.2073785" @default.
- W4280597972 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35549648" @default.
- W4280597972 hasPublicationYear "2022" @default.
- W4280597972 type Work @default.
- W4280597972 citedByCount "14" @default.
- W4280597972 countsByYear W42805979722022 @default.
- W4280597972 countsByYear W42805979722023 @default.
- W4280597972 crossrefType "journal-article" @default.
- W4280597972 hasAuthorship W4280597972A5004906371 @default.
- W4280597972 hasAuthorship W4280597972A5013656851 @default.
- W4280597972 hasAuthorship W4280597972A5027136794 @default.
- W4280597972 hasAuthorship W4280597972A5046211215 @default.
- W4280597972 hasAuthorship W4280597972A5052880029 @default.
- W4280597972 hasAuthorship W4280597972A5053957639 @default.
- W4280597972 hasAuthorship W4280597972A5059065464 @default.
- W4280597972 hasAuthorship W4280597972A5065941887 @default.
- W4280597972 hasBestOaLocation W42805979721 @default.
- W4280597972 hasConcept C121608353 @default.
- W4280597972 hasConcept C126322002 @default.
- W4280597972 hasConcept C13373296 @default.
- W4280597972 hasConcept C164027704 @default.
- W4280597972 hasConcept C203014093 @default.
- W4280597972 hasConcept C2776107976 @default.
- W4280597972 hasConcept C2776317360 @default.
- W4280597972 hasConcept C2776914184 @default.
- W4280597972 hasConcept C2780014169 @default.
- W4280597972 hasConcept C2780183776 @default.