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- W4280599299 abstract "Abstract A short total synthesis of tunicamycin V ( 1 ), a non‐selective phosphotransferase inhibitor, is achieved via a Büchner–Curtius–Schlotterbeck type reaction. Tunicamycin V can be synthesized in 15 chemical steps from D‐galactal with 21 % overall yield. The established synthetic scheme is operationally very simple and flexible to introduce building blocks of interest. The inhibitory activity of one of the designed analogues 28 against human dolichyl‐phosphate N ‐acetylglucosaminephosphotransferase 1 (DPAGT1) is 12.5 times greater than 1 . While tunicamycins are cytotoxic molecules with a low selectivity, the novel analogue 28 displays selective cytostatic activity against breast cancer cell lines including a triple‐negative breast cancer." @default.
- W4280599299 created "2022-05-22" @default.
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- W4280599299 date "2022-06-10" @default.
- W4280599299 modified "2023-10-18" @default.
- W4280599299 title "Concise Synthesis of Tunicamycin V and Discovery of a Cytostatic DPAGT1 Inhibitor" @default.
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- W4280599299 cites W147518931 @default.
- W4280599299 cites W1511326535 @default.
- W4280599299 cites W1536018768 @default.
- W4280599299 cites W1584822782 @default.
- W4280599299 cites W1906271606 @default.
- W4280599299 cites W1959885463 @default.
- W4280599299 cites W1960207578 @default.
- W4280599299 cites W1964316590 @default.
- W4280599299 cites W1967017855 @default.
- W4280599299 cites W1970271740 @default.
- W4280599299 cites W1971046082 @default.
- W4280599299 cites W1980093591 @default.
- W4280599299 cites W1981381473 @default.
- W4280599299 cites W1985588649 @default.
- W4280599299 cites W1985748437 @default.
- W4280599299 cites W1987482623 @default.
- W4280599299 cites W1988283968 @default.
- W4280599299 cites W1993800646 @default.
- W4280599299 cites W1996888414 @default.
- W4280599299 cites W2002467554 @default.
- W4280599299 cites W2004362295 @default.
- W4280599299 cites W2005159078 @default.
- W4280599299 cites W2005257160 @default.
- W4280599299 cites W2009423060 @default.
- W4280599299 cites W2012028316 @default.
- W4280599299 cites W2017556715 @default.
- W4280599299 cites W2019397921 @default.
- W4280599299 cites W2020152798 @default.
- W4280599299 cites W2022476421 @default.
- W4280599299 cites W2027163343 @default.
- W4280599299 cites W2032822173 @default.
- W4280599299 cites W2033575054 @default.
- W4280599299 cites W2042364508 @default.
- W4280599299 cites W2044568919 @default.
- W4280599299 cites W2047867372 @default.
- W4280599299 cites W2049068032 @default.
- W4280599299 cites W2054930916 @default.
- W4280599299 cites W2062222527 @default.
- W4280599299 cites W2066718496 @default.
- W4280599299 cites W2066958651 @default.
- W4280599299 cites W2067694656 @default.
- W4280599299 cites W2074893936 @default.
- W4280599299 cites W2075830632 @default.
- W4280599299 cites W2076813700 @default.
- W4280599299 cites W2080042102 @default.
- W4280599299 cites W2083637184 @default.
- W4280599299 cites W2088575034 @default.
- W4280599299 cites W2102377211 @default.
- W4280599299 cites W2109364834 @default.
- W4280599299 cites W2114300995 @default.
- W4280599299 cites W2123853171 @default.
- W4280599299 cites W2128635703 @default.
- W4280599299 cites W2140838225 @default.
- W4280599299 cites W2155653749 @default.
- W4280599299 cites W2230552681 @default.
- W4280599299 cites W2319195575 @default.
- W4280599299 cites W2342743584 @default.
- W4280599299 cites W2462152314 @default.
- W4280599299 cites W2513366658 @default.
- W4280599299 cites W2515832379 @default.
- W4280599299 cites W2518930067 @default.
- W4280599299 cites W2745038245 @default.
- W4280599299 cites W2759753490 @default.
- W4280599299 cites W2781318237 @default.
- W4280599299 cites W2788202691 @default.
- W4280599299 cites W2791476169 @default.
- W4280599299 cites W2792059098 @default.
- W4280599299 cites W2795719567 @default.
- W4280599299 cites W2913380570 @default.
- W4280599299 cites W2924343006 @default.
- W4280599299 cites W2949939820 @default.
- W4280599299 cites W2950695154 @default.
- W4280599299 cites W2951165306 @default.
- W4280599299 cites W3004492666 @default.
- W4280599299 cites W3024966196 @default.
- W4280599299 cites W3083349772 @default.
- W4280599299 cites W3146339966 @default.
- W4280599299 cites W3148470348 @default.
- W4280599299 cites W370614919 @default.
- W4280599299 cites W4230619447 @default.
- W4280599299 cites W4233370580 @default.
- W4280599299 doi "https://doi.org/10.1002/anie.202203225" @default.
- W4280599299 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35594368" @default.
- W4280599299 hasPublicationYear "2022" @default.
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