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- W4280600890 abstract "Bladder cancer is the 10th most frequently diagnosed cancer worldwide with 5-year survival rate around 70%. The current first-line treatment for non-muscle invasive bladder cancer is transurethral resection of bladder tumours followed by intravesical Mycobacterium Bovis Bacillus Calmette-Guérin (BCG) immunotherapy. However, tumor recurrence rate is still high ranging from 31% to 78% within five years. To avoid radical cystectomy, intravesical combination therapies have been developed as salvage treatments to overcome BCG failure. Recent advances in diagnostics thanks to tumor molecular profiling and in treatment such as development of immunotherapies provides more treatment options beyond BCG treatment. This also goes hand-in hand with formulation advances to deliver these new therapies where traditional drug delivery systems might not be suitable, which in turn is completed by challenges to deliver drugs via the intravesical route. In this article the aim was to provide an in-depth analysis of the current developments of intravesical combination therapies, ranging from relatively simple combinations of mixing existed intravesical therapeutic agents (immunotherapies and chemotherapies) to the combined formulations containing advanced gene therapies and targeted therapies, with special focus on therapies that have made it to the clinical trial stage. In addition, recent attempts to utilize device-assisted treatments and novel drug delivery platforms are included. This review also highlights the limitations that still need to be overcome such as the inadequate studies on newly explored drug carriers and proposes potential directions for future work to overcome BCG-failure." @default.
- W4280600890 created "2022-05-22" @default.
- W4280600890 creator A5051190412 @default.
- W4280600890 creator A5052547773 @default.
- W4280600890 creator A5090574722 @default.
- W4280600890 date "2022-07-01" @default.
- W4280600890 modified "2023-10-18" @default.
- W4280600890 title "Intravesical combination therapies for non-muscle invasive bladder cancer: Recent advances and future directions" @default.
- W4280600890 cites W1538193234 @default.
- W4280600890 cites W1912481925 @default.
- W4280600890 cites W1941626268 @default.
- W4280600890 cites W1943753928 @default.
- W4280600890 cites W1966900148 @default.
- W4280600890 cites W1978510140 @default.
- W4280600890 cites W2002045993 @default.
- W4280600890 cites W2006899019 @default.
- W4280600890 cites W2027633833 @default.
- W4280600890 cites W2038363332 @default.
- W4280600890 cites W2043283767 @default.
- W4280600890 cites W2045299439 @default.
- W4280600890 cites W2047988255 @default.
- W4280600890 cites W2058887964 @default.
- W4280600890 cites W2063254240 @default.
- W4280600890 cites W2065244452 @default.
- W4280600890 cites W2072728628 @default.
- W4280600890 cites W2082941803 @default.
- W4280600890 cites W2084661702 @default.
- W4280600890 cites W2091709786 @default.
- W4280600890 cites W2091808986 @default.
- W4280600890 cites W2094764750 @default.
- W4280600890 cites W2100508256 @default.
- W4280600890 cites W2113156769 @default.
- W4280600890 cites W2126747820 @default.
- W4280600890 cites W2128388706 @default.
- W4280600890 cites W2140516194 @default.
- W4280600890 cites W2146391374 @default.
- W4280600890 cites W2149083988 @default.
- W4280600890 cites W2151575881 @default.
- W4280600890 cites W2151956834 @default.
- W4280600890 cites W2152455106 @default.
- W4280600890 cites W2158803251 @default.
- W4280600890 cites W2174702408 @default.
- W4280600890 cites W2270022169 @default.
- W4280600890 cites W2293986631 @default.
- W4280600890 cites W2322319972 @default.
- W4280600890 cites W2331426679 @default.
- W4280600890 cites W2396217311 @default.
- W4280600890 cites W2443056117 @default.
- W4280600890 cites W2471231341 @default.
- W4280600890 cites W2472545738 @default.
- W4280600890 cites W2593384642 @default.
- W4280600890 cites W2601455053 @default.
- W4280600890 cites W2607151714 @default.
- W4280600890 cites W2609464379 @default.
- W4280600890 cites W2612505952 @default.
- W4280600890 cites W2742039692 @default.
- W4280600890 cites W2745280969 @default.
- W4280600890 cites W2765431857 @default.
- W4280600890 cites W2783414919 @default.
- W4280600890 cites W2793368320 @default.
- W4280600890 cites W2801008036 @default.
- W4280600890 cites W2884458916 @default.
- W4280600890 cites W2889858611 @default.
- W4280600890 cites W2891837297 @default.
- W4280600890 cites W2893171711 @default.
- W4280600890 cites W2900445666 @default.
- W4280600890 cites W2903162255 @default.
- W4280600890 cites W2921225557 @default.
- W4280600890 cites W2943637389 @default.
- W4280600890 cites W2969298181 @default.
- W4280600890 cites W2969983122 @default.
- W4280600890 cites W2970692557 @default.
- W4280600890 cites W2990926740 @default.
- W4280600890 cites W2990978701 @default.
- W4280600890 cites W2991128887 @default.
- W4280600890 cites W2991834154 @default.
- W4280600890 cites W2998765636 @default.
- W4280600890 cites W3002208273 @default.
- W4280600890 cites W3010696323 @default.
- W4280600890 cites W3010996954 @default.
- W4280600890 cites W3046692122 @default.
- W4280600890 cites W3048531353 @default.
- W4280600890 cites W3106738902 @default.
- W4280600890 cites W3112410802 @default.
- W4280600890 cites W3122829455 @default.
- W4280600890 cites W3128646645 @default.
- W4280600890 cites W3135285485 @default.
- W4280600890 cites W3137516781 @default.
- W4280600890 cites W3156189329 @default.
- W4280600890 cites W3163011150 @default.
- W4280600890 cites W410120067 @default.
- W4280600890 cites W4211115520 @default.
- W4280600890 cites W594984707 @default.
- W4280600890 doi "https://doi.org/10.1016/j.ejphar.2022.175024" @default.
- W4280600890 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35580708" @default.
- W4280600890 hasPublicationYear "2022" @default.
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