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• W4280604262 abstract "Patients with Langerhans cell histiocytosis (LCH) may develop progressive neurodegeneration in the central nervous system (ND-CNS-LCH). Neurofilament light protein (NFL) in cerebrospinal fluid (CSF) is a promising biomarker to detect and monitor ND-CNS-LCH. We compared paired samples of NFL in plasma (p-NFL) and CSF in 10 patients (19 samples). Nine samples had abnormal CSF-NFL (defined as ≥380 ng/l) with corresponding p-NFL ≥ 2 ng/l. Ten samples had CSF-NFL < 380 ng/l; eight (80%) with p-NFL < 2 ng/l (p < 0.001; Fisher's exact test). Thus, our results suggest that p-NFL may be used to screen for ND-CNS-LCH. Further studies are encouraged, including the role of p-NFL for monitoring of ND-CNS-LCH." @default.
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• W4280604262 date "2022-05-17" @default.
• W4280604262 modified "2023-10-16" @default.
• W4280604262 title "Screening for neurodegeneration in Langerhans cell histiocytosis with neurofilament light in plasma" @default.
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• W4280604262 doi "https://doi.org/10.1111/bjh.18247" @default.
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