FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4280604521> ?p ?o ?g. }

• W4280604521 endingPage "106258" @default.
• W4280604521 startingPage "106258" @default.
• W4280604521 abstract "Cannabis sativa is a recreational drug commonly consumed in Europe and is getting popularity for both recreational and therapeutic use. In some individuals, the use of cannabis leads to psychotic disorders. This systematic review summarizes the current evidence linking genetic polymorphisms and inter-individual susceptibility to psychosis induced by cannabis.Studies published from 2005 to 2020 were identified through Medline using PubMed, Web of Science and Scopus database and searches were conducted according to PRISMA guidelines. Initial search was performed with terms: cannabis induced psychosis AND genetics.From the initial group of 108 papers, 18 studies met our inclusion criteria. Many of the findings revealed associations with genetic polymorphisms modulations of genes involved directly (COMT, DRD2 and DAT) or indirectly (AKT1) to dopamine pathways. The most consistent finding was with COMT rs4680, where the presence of the Val allele was associated with a higher risk for cannabis-induced psychosis. This higher susceptibility was also reported for AKT1 (rs2494732) with the CC genotype. Of note, the only genome-wide association study identified a significant signal close to the cholinergic receptor muscarinic 3 represented by rs115455482 and rs74722579 predisposing to cannabis-induced hallucinations and remarkably no dopaminergic target was found.Actual evidence supports the role of dopamine in cannabis induced psychosis. However, most of genetic polymorphism studies have as a starting point the pre-existing dopaminergic theoretical basis for psychosis. This alerts to the importance of more broad genetic studies. Integrate genetic results into biological systems may enhance our knowledge of cannabis induced psychosis and could help in the prevention and treatment of these patients." @default.
• W4280604521 created "2022-05-22" @default.
• W4280604521 creator A5014368917 @default.
• W4280604521 creator A5068523585 @default.
• W4280604521 date "2022-07-01" @default.
• W4280604521 modified "2023-09-25" @default.
• W4280604521 title "Cannabis induced psychosis: A systematic review on the role of genetic polymorphisms" @default.
• W4280604521 cites W1494737704 @default.
• W4280604521 cites W1532526167 @default.
• W4280604521 cites W1964598242 @default.
• W4280604521 cites W1968451659 @default.
• W4280604521 cites W1969177940 @default.
• W4280604521 cites W1973371295 @default.
• W4280604521 cites W1982170224 @default.
• W4280604521 cites W1986059489 @default.
• W4280604521 cites W1995540460 @default.
• W4280604521 cites W2007118330 @default.
• W4280604521 cites W2007497521 @default.
• W4280604521 cites W2012104550 @default.
• W4280604521 cites W2016013658 @default.
• W4280604521 cites W2020233785 @default.
• W4280604521 cites W2040333240 @default.
• W4280604521 cites W2044905780 @default.
• W4280604521 cites W2052480269 @default.
• W4280604521 cites W2099241624 @default.
• W4280604521 cites W2102581653 @default.
• W4280604521 cites W2104532446 @default.
• W4280604521 cites W2118829128 @default.
• W4280604521 cites W2119780182 @default.
• W4280604521 cites W2126551481 @default.
• W4280604521 cites W2132622226 @default.
• W4280604521 cites W2132971116 @default.
• W4280604521 cites W2133139089 @default.
• W4280604521 cites W2136435339 @default.
• W4280604521 cites W2139565721 @default.
• W4280604521 cites W2140616116 @default.
• W4280604521 cites W2144035284 @default.
• W4280604521 cites W2146561516 @default.
• W4280604521 cites W2156291077 @default.
• W4280604521 cites W2158902140 @default.
• W4280604521 cites W2160695817 @default.
• W4280604521 cites W2161411148 @default.
• W4280604521 cites W2163525833 @default.
• W4280604521 cites W2168111104 @default.
• W4280604521 cites W2169269177 @default.
• W4280604521 cites W2171396692 @default.
• W4280604521 cites W2274449219 @default.
• W4280604521 cites W2309274031 @default.
• W4280604521 cites W2336838470 @default.
• W4280604521 cites W2368147362 @default.
• W4280604521 cites W2468996569 @default.
• W4280604521 cites W2582094868 @default.
• W4280604521 cites W2606124421 @default.
• W4280604521 cites W2761378349 @default.
• W4280604521 cites W2917386159 @default.
• W4280604521 cites W2943898410 @default.
• W4280604521 cites W2944629200 @default.
• W4280604521 cites W2967886983 @default.
• W4280604521 cites W2979988116 @default.
• W4280604521 cites W3005082022 @default.
• W4280604521 cites W3007673547 @default.
• W4280604521 cites W3010630442 @default.
• W4280604521 cites W3012161732 @default.
• W4280604521 cites W3013001666 @default.
• W4280604521 cites W3019503148 @default.
• W4280604521 cites W3025967505 @default.
• W4280604521 cites W3082982504 @default.
• W4280604521 cites W3111803123 @default.
• W4280604521 cites W3134721632 @default.
• W4280604521 cites W3136202165 @default.
• W4280604521 cites W3199951847 @default.
• W4280604521 cites W3216825328 @default.
• W4280604521 cites W4214661323 @default.
• W4280604521 doi "https://doi.org/10.1016/j.phrs.2022.106258" @default.
• W4280604521 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35588917" @default.
• W4280604521 hasPublicationYear "2022" @default.
• W4280604521 type Work @default.
• W4280604521 citedByCount "9" @default.
• W4280604521 countsByYear W42806045212022 @default.
• W4280604521 countsByYear W42806045212023 @default.
• W4280604521 crossrefType "journal-article" @default.
• W4280604521 hasAuthorship W4280604521A5014368917 @default.
• W4280604521 hasAuthorship W4280604521A5068523585 @default.
• W4280604521 hasBestOaLocation W42806045211 @default.
• W4280604521 hasConcept C104317684 @default.
• W4280604521 hasConcept C118552586 @default.
• W4280604521 hasConcept C126322002 @default.
• W4280604521 hasConcept C135763542 @default.
• W4280604521 hasConcept C137183658 @default.
• W4280604521 hasConcept C15744967 @default.
• W4280604521 hasConcept C185361966 @default.
• W4280604521 hasConcept C2776286997 @default.
• W4280604521 hasConcept C2776895053 @default.
• W4280604521 hasConcept C2777056318 @default.
• W4280604521 hasConcept C2778524067 @default.
• W4280604521 hasConcept C2779727114 @default.
• W4280604521 hasConcept C2780313146 @default.
• W4280604521 hasConcept C513476851 @default.

• next