Matches in SemOpenAlex for { <https://semopenalex.org/work/W4280615423> ?p ?o ?g. }
- W4280615423 endingPage "102037" @default.
- W4280615423 startingPage "102037" @default.
- W4280615423 abstract "NAD+ is a versatile biomolecule acting as a master regulator and substrate in various cellular processes, including redox regulation, metabolism, and various signaling pathways. In this article, we concisely and critically review the role of NAD+ in mechanisms promoting genome maintenance. Numerous NAD+-dependent reactions are involved in the preservation of genome stability, the cellular DNA damage response, and other pathways regulating nucleic acid metabolism, such as gene expression and cell proliferation pathways. Of note, NAD+ serves as a substrate to ADP-ribosyltransferases, sirtuins, and potentially also eukaryotic DNA ligases, all of which regulate various aspects of DNA integrity, damage repair, and gene expression. Finally, we critically analyze recent developments in the field as well as discuss challenges associated with therapeutic actions intended to raise NAD+ levels." @default.
- W4280615423 created "2022-05-22" @default.
- W4280615423 creator A5021983212 @default.
- W4280615423 creator A5026754150 @default.
- W4280615423 creator A5034232966 @default.
- W4280615423 date "2022-06-01" @default.
- W4280615423 modified "2023-10-05" @default.
- W4280615423 title "Fueling genome maintenance: On the versatile roles of NAD+ in preserving DNA integrity" @default.
- W4280615423 cites W1486865933 @default.
- W4280615423 cites W1502236509 @default.
- W4280615423 cites W1537637917 @default.
- W4280615423 cites W165258051 @default.
- W4280615423 cites W1738677317 @default.
- W4280615423 cites W1823374409 @default.
- W4280615423 cites W1852538637 @default.
- W4280615423 cites W1935791661 @default.
- W4280615423 cites W1945628007 @default.
- W4280615423 cites W1946157893 @default.
- W4280615423 cites W1960241973 @default.
- W4280615423 cites W1963982942 @default.
- W4280615423 cites W1966928113 @default.
- W4280615423 cites W1967354453 @default.
- W4280615423 cites W1971012430 @default.
- W4280615423 cites W1972924731 @default.
- W4280615423 cites W1973123264 @default.
- W4280615423 cites W1973327581 @default.
- W4280615423 cites W1978814196 @default.
- W4280615423 cites W1979313505 @default.
- W4280615423 cites W1985075679 @default.
- W4280615423 cites W1993180847 @default.
- W4280615423 cites W1995450526 @default.
- W4280615423 cites W1999855539 @default.
- W4280615423 cites W2002233209 @default.
- W4280615423 cites W2010206811 @default.
- W4280615423 cites W2011734403 @default.
- W4280615423 cites W2011774966 @default.
- W4280615423 cites W2011930674 @default.
- W4280615423 cites W2012147370 @default.
- W4280615423 cites W2013128717 @default.
- W4280615423 cites W2013844116 @default.
- W4280615423 cites W2014058353 @default.
- W4280615423 cites W2014300705 @default.
- W4280615423 cites W2015019014 @default.
- W4280615423 cites W2016252363 @default.
- W4280615423 cites W2019106516 @default.
- W4280615423 cites W2019775979 @default.
- W4280615423 cites W2020304127 @default.
- W4280615423 cites W2020311873 @default.
- W4280615423 cites W2021837487 @default.
- W4280615423 cites W2024876727 @default.
- W4280615423 cites W2025139162 @default.
- W4280615423 cites W2026011189 @default.
- W4280615423 cites W2028178274 @default.
- W4280615423 cites W2029108569 @default.
- W4280615423 cites W2029969982 @default.
- W4280615423 cites W2031123264 @default.
- W4280615423 cites W2031357962 @default.
- W4280615423 cites W2034502973 @default.
- W4280615423 cites W2035388291 @default.
- W4280615423 cites W2039774617 @default.
- W4280615423 cites W2040414192 @default.
- W4280615423 cites W2042716686 @default.
- W4280615423 cites W2045442669 @default.
- W4280615423 cites W2045601092 @default.
- W4280615423 cites W2046232891 @default.
- W4280615423 cites W2047230408 @default.
- W4280615423 cites W2047380283 @default.
- W4280615423 cites W2050104597 @default.
- W4280615423 cites W2050412495 @default.
- W4280615423 cites W2054394510 @default.
- W4280615423 cites W2054866841 @default.
- W4280615423 cites W2056679680 @default.
- W4280615423 cites W2057770806 @default.
- W4280615423 cites W2063084036 @default.
- W4280615423 cites W2064424247 @default.
- W4280615423 cites W2066204526 @default.
- W4280615423 cites W2067395145 @default.
- W4280615423 cites W2067818013 @default.
- W4280615423 cites W2068128334 @default.
- W4280615423 cites W2068229221 @default.
- W4280615423 cites W2070350696 @default.
- W4280615423 cites W2070758111 @default.
- W4280615423 cites W2071457560 @default.
- W4280615423 cites W2072550119 @default.
- W4280615423 cites W2074343204 @default.
- W4280615423 cites W2074931602 @default.
- W4280615423 cites W2075012277 @default.
- W4280615423 cites W2076252987 @default.
- W4280615423 cites W2077559325 @default.
- W4280615423 cites W2077630337 @default.
- W4280615423 cites W2079891276 @default.
- W4280615423 cites W2082740501 @default.
- W4280615423 cites W2089126898 @default.
- W4280615423 cites W2092488984 @default.
- W4280615423 cites W2094807579 @default.
- W4280615423 cites W2095264331 @default.
- W4280615423 cites W2097345307 @default.
- W4280615423 cites W2102322990 @default.