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• W4280618114 abstract "To investigate the associations of weight change patterns across adulthood with the risk of non-alcoholic fatty liver disease (NAFLD).Using data from the National Health and Nutrition Examination Survey (NHANES) 2017-2018 cycle, we performed a retrospective cohort study with 2212 non-obese participants aged 36 years old over. Weight change patterns were categorized as stable non-obese, early adulthood weight gain, middle and late adulthood weight gain and revert to non-obese according to the body mass index (BMI) at age 25, 10 years prior and at baseline. Vibration-controlled transient elastography (VCTE) was performed to diagnose NAFLD. Modified Poisson regression was used to quantify the associations of weight change patterns with NAFLD.Compared with participants in the stable non-obese group, those who gained weight at early or middle and late adulthood had an increased risk of NAFLD, with an adjusted rate ratio (RR) of 2.19 (95% CI 1.64-2.91) and 1.92 (95% CI 1.40-2.62), respectively. The risk of NAFLD in revert to the non-obese group showed no significant difference with the stable non-obese group. If the association of weight change and NAFLD was causal, we estimated that 73.09% (95% CI 55.62-82.93%) of incident NAFLD would be prevented if the total population had a normal BMI across adulthood.Weight gain to obese at early or middle and late adulthood was associated with an evaluated risk of NAFLD. A large proportion would have been prevented with effective weight intervention." @default.
• W4280618114 created "2022-05-22" @default.
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• W4280618114 date "2022-05-20" @default.
• W4280618114 modified "2023-10-14" @default.
• W4280618114 title "Weight Change across Adulthood in Relation to Non-Alcoholic Fatty Liver Disease among Non-Obese Individuals" @default.
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• W4280618114 doi "https://doi.org/10.3390/nu14102140" @default.
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