Matches in SemOpenAlex for { <https://semopenalex.org/work/W4280628577> ?p ?o ?g. }
- W4280628577 abstract "Abstract The placenta serves as a connection between the mother and the fetus during pregnancy, and provides the fetus with oxygen, nutrients, and growth hormones. However, the regulatory mechanisms and dynamic gene interaction networks underlying early placental development are understudied. Here, we generated RNA sequencing (RNA-seq) data from mouse fetal placenta tissues at embryonic day (e) 7.5, e8.5 and e9.5 to identify genes with timepoint-specific expression, then inferred gene interaction networks to analyze highly connected network modules. We determined that timepoint-specific gene network modules associated with distinct developmental processes, and with similar expression profiles to specific human placental cell populations. From each module, we obtained hub genes and their direct neighboring genes, which were predicted to govern placental functions. We confirmed that four novel candidate regulators identified through our analyses regulate cell migration in the HTR-8/SVneo cell line. Upon conclusion of this study, we were able to predict several novel regulators of placental development using network analysis of bulk RNA-seq data. Our findings and analysis approaches will be valuable for future studies investigating the transcriptional landscape of early placental development." @default.
- W4280628577 created "2022-05-22" @default.
- W4280628577 creator A5017728974 @default.
- W4280628577 creator A5043225657 @default.
- W4280628577 creator A5076325815 @default.
- W4280628577 creator A5076507980 @default.
- W4280628577 creator A5091612804 @default.
- W4280628577 date "2022-05-17" @default.
- W4280628577 modified "2023-09-24" @default.
- W4280628577 title "Identifying novel regulators of placental development using time series transcriptomic data and network analyses" @default.
- W4280628577 cites W139879992 @default.
- W4280628577 cites W1481669947 @default.
- W4280628577 cites W1509926487 @default.
- W4280628577 cites W1519055237 @default.
- W4280628577 cites W1562698629 @default.
- W4280628577 cites W1939026529 @default.
- W4280628577 cites W1939326986 @default.
- W4280628577 cites W1969772038 @default.
- W4280628577 cites W1975878158 @default.
- W4280628577 cites W1980401378 @default.
- W4280628577 cites W1982739109 @default.
- W4280628577 cites W1996534200 @default.
- W4280628577 cites W1999065094 @default.
- W4280628577 cites W2001585146 @default.
- W4280628577 cites W2005133979 @default.
- W4280628577 cites W2008572860 @default.
- W4280628577 cites W2010798628 @default.
- W4280628577 cites W2016996762 @default.
- W4280628577 cites W2036962858 @default.
- W4280628577 cites W2041799836 @default.
- W4280628577 cites W2047767415 @default.
- W4280628577 cites W2050672781 @default.
- W4280628577 cites W2050919257 @default.
- W4280628577 cites W2056611451 @default.
- W4280628577 cites W2056711495 @default.
- W4280628577 cites W2058972167 @default.
- W4280628577 cites W2064412682 @default.
- W4280628577 cites W2076513103 @default.
- W4280628577 cites W2099199686 @default.
- W4280628577 cites W2105861563 @default.
- W4280628577 cites W2113400357 @default.
- W4280628577 cites W2113511096 @default.
- W4280628577 cites W2118199431 @default.
- W4280628577 cites W2121236039 @default.
- W4280628577 cites W2121904054 @default.
- W4280628577 cites W2123101895 @default.
- W4280628577 cites W2131271579 @default.
- W4280628577 cites W2131840335 @default.
- W4280628577 cites W2133159319 @default.
- W4280628577 cites W2133811885 @default.
- W4280628577 cites W2133989655 @default.
- W4280628577 cites W2136874026 @default.
- W4280628577 cites W2141012957 @default.
- W4280628577 cites W2141712789 @default.
- W4280628577 cites W2149290739 @default.
- W4280628577 cites W2159675211 @default.
- W4280628577 cites W2160348817 @default.
- W4280628577 cites W2165891030 @default.
- W4280628577 cites W2167564942 @default.
- W4280628577 cites W2172055078 @default.
- W4280628577 cites W2175763086 @default.
- W4280628577 cites W2188422153 @default.
- W4280628577 cites W2259285077 @default.
- W4280628577 cites W2297417484 @default.
- W4280628577 cites W2323326409 @default.
- W4280628577 cites W2325682670 @default.
- W4280628577 cites W2341084084 @default.
- W4280628577 cites W2506127557 @default.
- W4280628577 cites W2547416997 @default.
- W4280628577 cites W2587223131 @default.
- W4280628577 cites W2620721366 @default.
- W4280628577 cites W2739329039 @default.
- W4280628577 cites W2786428929 @default.
- W4280628577 cites W2789265970 @default.
- W4280628577 cites W2809971539 @default.
- W4280628577 cites W2887929911 @default.
- W4280628577 cites W2891678790 @default.
- W4280628577 cites W2896827002 @default.
- W4280628577 cites W2898351291 @default.
- W4280628577 cites W2900144939 @default.
- W4280628577 cites W2900569176 @default.
- W4280628577 cites W2924530200 @default.
- W4280628577 cites W2926010705 @default.
- W4280628577 cites W2934489113 @default.
- W4280628577 cites W2935104625 @default.
- W4280628577 cites W2939973050 @default.
- W4280628577 cites W2946173685 @default.
- W4280628577 cites W2952027905 @default.
- W4280628577 cites W2952944806 @default.
- W4280628577 cites W2953007287 @default.
- W4280628577 cites W2973774575 @default.
- W4280628577 cites W2997823808 @default.
- W4280628577 cites W3000377151 @default.
- W4280628577 cites W3030331965 @default.
- W4280628577 cites W3095295339 @default.
- W4280628577 cites W3095467892 @default.
- W4280628577 cites W3135276664 @default.
- W4280628577 cites W3168521457 @default.
- W4280628577 cites W3169130065 @default.
- W4280628577 cites W3174222497 @default.