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• W4280637509 abstract "Abstract Intervertebral disc degeneration (IVDD) demonstrates a gradually increased incidence and has developed into a major health problem worldwide. Nucleus pulposus is characterized by the hypoxic and avascular environment, in which hypoxia inducible factor1α (HIF-1α) has an important role through its participation in extracellular matrix synthesis, energy metabolism, cellular adaptation to stresses and genesis. In this study, the effects of HIF-1α on mouse primary nucleus pulposus cells (MNPCs) exposed to TNF-α were observed and the potential mechanism was explored, and a rabbit IVDD model was established to verify the protective role of HIF-1α on IVDD. In vitro results demonstrated that HIF-1α could attenuate the inflammation, apoptosis and mitochondrial dysfunction induced by TNF-α in MNPCs, and promote cellular anabolism, and inhibit cellular catabolism. In vivo results demonstrated that after establishment of IVDD model in rabbit, disc height and IVD extracellular matrix were decreased in a time-dependent manner, and MRI analysis showed a tendency for decreased T2 values in a time-dependent manner, and supplementation of HIF-1α improved histological and imaginative IVDD while down-regulation of HIF-1α exacerbated this degeneration. In summary, HIF-1α protected against IVDD, possibly through reducing ROS production in mitochondria and consequent inhibition of inflammation, metabolism disorders and apoptosis of MNPCs, which provided a potential therapeutic instrument for treatment of IVDD diseases." @default.
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• W4280637509 date "2022-05-13" @default.
• W4280637509 modified "2023-09-29" @default.
• W4280637509 title "Hypoxia-inducible Factor-1α protects against Intervertebral Disc Degeneration through Antagonizing Mitochondrial Oxidative Stress." @default.
• W4280637509 doi "https://doi.org/10.21203/rs.3.rs-1637390/v1" @default.
• W4280637509 hasPublicationYear "2022" @default.
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