FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4280639199> ?p ?o ?g. }

• W4280639199 endingPage "184" @default.
• W4280639199 startingPage "184" @default.
• W4280639199 abstract "Abrin is a cytotoxin with strong lethality, which is a serious threat to human health and public safety, and thus, highly sensitive detection methods are urgently needed. The phage display affibody has two major modules, among which, the affibody fragment, with small molecular weight, high affinity and easy preparation, can be used for the specific recognition of the target, and the phage shell, with numerous protein copies, can be used as a carrier for the massive enrichment of signal molecules, and thus is particularly suitable as a sensitive probe for signal amplification in high-sensitivity biosensors. In this study, with antibody-coated magnetic microspheres as capture probes, Ru(bpy)32+ and biotin dual-labeled phage display affibodies as the specific signal probes and AuNPs@Ru(bpy)32+ (Ru(bpy)32+-coated gold nanoparticles) as the signal amplification nanomaterials, a new electrochemiluminescence (ECL) biosensor with a four-level sandwich structure of “magnetic capture probe-abrin-phage display affibody-AuNPs@Ru(bpy)32+” was constructed for abrin detection. In this detection mode, AuNPs@Ru(bpy)32+, a gold nanocomposite prepared rapidly via electrical interaction, contained an extremely high density of signal molecules, and the phage display affibodies with powerful loading capacity were not only labeled with Ru(bpy)32+, but also enriched with AuNPs@Ru(bpy)32+ in large amounts. These designs greatly improved the detection capability of the sensor, ultimately achieving the ultra-sensitive detection of abrin. The limit of detection (LOD) was 4.1 fg/mL (3δ/S), and the quantification range was from 5 fg/mL to 5 pg/mL. The sensor had good reproducibility and specificity and performed well in the test of simulated samples. This study expanded the application of affibodies in the field of biosensing and also deeply explored the signal amplification potential of phage display technology, which is of high value for the construction of simple and efficient sensors with high sensitivity." @default.
• W4280639199 created "2022-05-22" @default.
• W4280639199 creator A5002076661 @default.
• W4280639199 creator A5002591086 @default.
• W4280639199 creator A5011799368 @default.
• W4280639199 creator A5014528965 @default.
• W4280639199 creator A5022055126 @default.
• W4280639199 creator A5031238943 @default.
• W4280639199 creator A5057959786 @default.
• W4280639199 creator A5068112672 @default.
• W4280639199 creator A5073761230 @default.
• W4280639199 creator A5088159502 @default.
• W4280639199 date "2022-05-13" @default.
• W4280639199 modified "2023-10-16" @default.
• W4280639199 title "Phage Display Affibodies Combined with AuNPs@Ru(bpy)32+ for Ultra-Sensitive Electrochemiluminescence Detection of Abrin" @default.
• W4280639199 cites W1993870692 @default.
• W4280639199 cites W2000129147 @default.
• W4280639199 cites W2002336955 @default.
• W4280639199 cites W2012536704 @default.
• W4280639199 cites W2039225776 @default.
• W4280639199 cites W2044440155 @default.
• W4280639199 cites W2049848125 @default.
• W4280639199 cites W2066360014 @default.
• W4280639199 cites W2080727188 @default.
• W4280639199 cites W2082112689 @default.
• W4280639199 cites W2085783726 @default.
• W4280639199 cites W2087289751 @default.
• W4280639199 cites W2092492380 @default.
• W4280639199 cites W2158500698 @default.
• W4280639199 cites W2167250408 @default.
• W4280639199 cites W2291058091 @default.
• W4280639199 cites W2316736404 @default.
• W4280639199 cites W2323474012 @default.
• W4280639199 cites W2411266629 @default.
• W4280639199 cites W2531046423 @default.
• W4280639199 cites W2763932994 @default.
• W4280639199 cites W2790108700 @default.
• W4280639199 cites W29097282 @default.
• W4280639199 cites W3000051861 @default.
• W4280639199 cites W3005533560 @default.
• W4280639199 cites W3008940702 @default.
• W4280639199 cites W3014422005 @default.
• W4280639199 cites W3030219783 @default.
• W4280639199 cites W3031736289 @default.
• W4280639199 cites W3096811745 @default.
• W4280639199 cites W3128001346 @default.
• W4280639199 cites W3137600577 @default.
• W4280639199 cites W3159825106 @default.
• W4280639199 cites W3182017614 @default.
• W4280639199 cites W3188801304 @default.
• W4280639199 cites W3194882078 @default.
• W4280639199 cites W3215215193 @default.
• W4280639199 doi "https://doi.org/10.3390/chemosensors10050184" @default.
• W4280639199 hasPublicationYear "2022" @default.
• W4280639199 type Work @default.
• W4280639199 citedByCount "1" @default.
• W4280639199 countsByYear W42806391992023 @default.
• W4280639199 crossrefType "journal-article" @default.
• W4280639199 hasAuthorship W4280639199A5002076661 @default.
• W4280639199 hasAuthorship W4280639199A5002591086 @default.
• W4280639199 hasAuthorship W4280639199A5011799368 @default.
• W4280639199 hasAuthorship W4280639199A5014528965 @default.
• W4280639199 hasAuthorship W4280639199A5022055126 @default.
• W4280639199 hasAuthorship W4280639199A5031238943 @default.
• W4280639199 hasAuthorship W4280639199A5057959786 @default.
• W4280639199 hasAuthorship W4280639199A5068112672 @default.
• W4280639199 hasAuthorship W4280639199A5073761230 @default.
• W4280639199 hasAuthorship W4280639199A5088159502 @default.
• W4280639199 hasBestOaLocation W42806391991 @default.
• W4280639199 hasConcept C104819515 @default.
• W4280639199 hasConcept C119128265 @default.
• W4280639199 hasConcept C128972844 @default.
• W4280639199 hasConcept C138631740 @default.
• W4280639199 hasConcept C153911025 @default.
• W4280639199 hasConcept C155672457 @default.
• W4280639199 hasConcept C160756335 @default.
• W4280639199 hasConcept C171250308 @default.
• W4280639199 hasConcept C185592680 @default.
• W4280639199 hasConcept C186268636 @default.
• W4280639199 hasConcept C192562407 @default.
• W4280639199 hasConcept C21951064 @default.
• W4280639199 hasConcept C2779281246 @default.
• W4280639199 hasConcept C38965407 @default.
• W4280639199 hasConcept C43617362 @default.
• W4280639199 hasConcept C55493867 @default.
• W4280639199 hasConcept C86803240 @default.
• W4280639199 hasConceptScore W4280639199C104819515 @default.
• W4280639199 hasConceptScore W4280639199C119128265 @default.
• W4280639199 hasConceptScore W4280639199C128972844 @default.
• W4280639199 hasConceptScore W4280639199C138631740 @default.
• W4280639199 hasConceptScore W4280639199C153911025 @default.
• W4280639199 hasConceptScore W4280639199C155672457 @default.
• W4280639199 hasConceptScore W4280639199C160756335 @default.
• W4280639199 hasConceptScore W4280639199C171250308 @default.
• W4280639199 hasConceptScore W4280639199C185592680 @default.
• W4280639199 hasConceptScore W4280639199C186268636 @default.
• W4280639199 hasConceptScore W4280639199C192562407 @default.
• W4280639199 hasConceptScore W4280639199C21951064 @default.

• next