Matches in SemOpenAlex for { <https://semopenalex.org/work/W4280642534> ?p ?o ?g. }
- W4280642534 abstract "Chronic kidney disease (CKD) is defined by persistent urine aberrations, structural abnormalities, or impaired excretory renal function. Diabetes is the leading cause of CKD. Their common pathological manifestation is renal fibrosis. Approximately half of all patients with type 2 diabetes and one-third with type 1 diabetes will develop CKD. However, renal fibrosis mechanisms are still poorly understood, especially post-transcriptional and epigenetic regulation. And an unmet need remains for innovative treatment strategies for preventing, arresting, treating, and reversing diabetic kidney disease (DKD). People believe that protein methylation, including histone and non-histone, is an essential type of post-translational modification (PTM). However, prevalent reviews mainly focus on the causes such as DNA methylation. This review will take insights into the protein part. Furthermore, by emphasizing the close relationship between protein methylation and DKD, we will summarize the clinical research status and foresee the application prospect of protein methyltransferase (PMT) inhibitors in DKD treatment. In a nutshell, our review will contribute to a more profound understanding of DKD's molecular mechanism and inspire people to dig into this field." @default.
- W4280642534 created "2022-05-22" @default.
- W4280642534 creator A5015102287 @default.
- W4280642534 creator A5041438685 @default.
- W4280642534 creator A5042648817 @default.
- W4280642534 creator A5053984102 @default.
- W4280642534 creator A5055394930 @default.
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- W4280642534 creator A5086047660 @default.
- W4280642534 creator A5087879996 @default.
- W4280642534 date "2022-05-12" @default.
- W4280642534 modified "2023-10-18" @default.
- W4280642534 title "Protein Methylation in Diabetic Kidney Disease" @default.
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