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- W4280643170 abstract "Background: Type 2 diabetes affects the intestine. Food restriction (FR) promotes benefits, but the studies of its effects in rats are scarce. This study aims to analyze the influence of two type 2 diabetes models and FR over the intestine morphology. Methods: Thirty Wistar rats formed three groups (n=10/group) treated for two months: C (control); DE (diabetic with streptozotocin+cafeteria-style diet); and DN (diabetic with streptozotocin+nicotinamide). These groups were subdivided into six during two months: CC (control), CCR (control+food restriction), DEC (diabetic+standard diet), DER (diabetic+food restriction), DNC (diabetic+standard diet) and DNR (diabetic+food restriction). FR was 50% of the average daily dietary intake of group C. Jejunum and ileum samples were collected for evaluation of wall morphometry, goblet cell number, number and profile of myenteric neurons and glia. Results: The DE model promoted wall reduction in both segments, while DN jejunum was increased. Goblet cells were reduced in the jejunum for both diabetic models and FR. Both intestinal segments presented reduction of neuronal and glial myenteric populations in diabetes. Conclusions: FR promoted protection of myenteric neurons and glial cells against diabetic damage. The jejunum and ileum respond differently to diabetes and FR. FR has positive effects over the small intestine, mainly over the enteric nervous system." @default.
- W4280643170 created "2022-05-22" @default.
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- W4280643170 date "2022-04-06" @default.
- W4280643170 modified "2023-10-18" @default.
- W4280643170 title "Food restriction protects the myenteric nervous population of rats with type 2 diabetes mellitus / A restrição alimentar protege a população nervosa mioentérica de ratos com diabetes mellitus tipo 2" @default.
- W4280643170 doi "https://doi.org/10.34117/bjdv8n4-111" @default.
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