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- W4280644894 endingPage "104386" @default.
- W4280644894 startingPage "104386" @default.
- W4280644894 abstract "Recessive mutations in RNF216/TRIAD3 cause Gordon Holmes syndrome (GHS), in which dysfunction of the hypothalamic-pituitary-gonadal (HPG) axis and neurodegeneration are thought to be core phenotypes. We knocked out Rnf216/Triad3 in a gonadotropin-releasing hormone (GnRH) hypothalamic cell line. Rnf216/Triad3 knockout (KO) cells had decreased steady-state GnRH and calcium transients. Rnf216/Triad3 KO adult mice had reductions in GnRH neuron soma size and GnRH production without changes in neuron densities. In addition, KO male mice had smaller testicular volumes that were accompanied by an abnormal release of inhibin B and follicle-stimulating hormone, whereas KO females exhibited irregular estrous cycling. KO males, but not females, had reactive microglia in the hypothalamus. Conditional deletion of Rnf216/Triad3 in neural stem cells caused abnormal microglia expression in males, but reproductive function remained unaffected. Our findings show that dysfunction of RNF216/TRIAD3 affects the HPG axis and microglia in a region- and sex-dependent manner, implicating sex-specific therapeutic interventions for GHS." @default.
- W4280644894 created "2022-05-22" @default.
- W4280644894 creator A5014873813 @default.
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- W4280644894 date "2022-06-01" @default.
- W4280644894 modified "2023-09-30" @default.
- W4280644894 title "The E3 ubiquitin ligase RNF216/TRIAD3 is a key coordinator of the hypothalamic-pituitary-gonadal axis" @default.
- W4280644894 cites W1576427485 @default.
- W4280644894 cites W1747986823 @default.
- W4280644894 cites W1761323037 @default.
- W4280644894 cites W1874568289 @default.
- W4280644894 cites W1899910412 @default.
- W4280644894 cites W1922423641 @default.
- W4280644894 cites W1966495359 @default.
- W4280644894 cites W1968320713 @default.
- W4280644894 cites W1968963646 @default.
- W4280644894 cites W1971023808 @default.
- W4280644894 cites W1973260880 @default.
- W4280644894 cites W1976772834 @default.
- W4280644894 cites W1984310913 @default.
- W4280644894 cites W1984637659 @default.
- W4280644894 cites W1986796466 @default.
- W4280644894 cites W1988638496 @default.
- W4280644894 cites W1993914855 @default.
- W4280644894 cites W2004064281 @default.
- W4280644894 cites W2015386663 @default.
- W4280644894 cites W2021650069 @default.
- W4280644894 cites W2022247902 @default.
- W4280644894 cites W2023456872 @default.
- W4280644894 cites W2027421516 @default.
- W4280644894 cites W2033683607 @default.
- W4280644894 cites W2034427531 @default.
- W4280644894 cites W2035706079 @default.
- W4280644894 cites W2036514426 @default.
- W4280644894 cites W2037810224 @default.
- W4280644894 cites W2040211909 @default.
- W4280644894 cites W2042061032 @default.
- W4280644894 cites W2048662852 @default.
- W4280644894 cites W2049216809 @default.
- W4280644894 cites W2050595554 @default.
- W4280644894 cites W2052453595 @default.
- W4280644894 cites W2057244558 @default.
- W4280644894 cites W2057425909 @default.
- W4280644894 cites W2062499257 @default.
- W4280644894 cites W2063807916 @default.
- W4280644894 cites W2065105581 @default.
- W4280644894 cites W2067551497 @default.
- W4280644894 cites W2077305451 @default.
- W4280644894 cites W2079320255 @default.
- W4280644894 cites W2080363423 @default.
- W4280644894 cites W2081160423 @default.
- W4280644894 cites W2082429191 @default.
- W4280644894 cites W2091896206 @default.
- W4280644894 cites W2094765096 @default.
- W4280644894 cites W2095578290 @default.
- W4280644894 cites W2096790979 @default.
- W4280644894 cites W2098009444 @default.
- W4280644894 cites W2104394703 @default.
- W4280644894 cites W2106070783 @default.
- W4280644894 cites W2107277218 @default.
- W4280644894 cites W2107554012 @default.
- W4280644894 cites W2109004804 @default.
- W4280644894 cites W2111338104 @default.
- W4280644894 cites W2112880160 @default.
- W4280644894 cites W2113304473 @default.
- W4280644894 cites W2122896471 @default.
- W4280644894 cites W2127717862 @default.
- W4280644894 cites W2128381336 @default.
- W4280644894 cites W2129786180 @default.
- W4280644894 cites W2135504928 @default.
- W4280644894 cites W2137988068 @default.
- W4280644894 cites W2138668032 @default.
- W4280644894 cites W2142686356 @default.
- W4280644894 cites W2143506157 @default.
- W4280644894 cites W2147917253 @default.
- W4280644894 cites W2158795213 @default.
- W4280644894 cites W2165643659 @default.
- W4280644894 cites W2166987747 @default.
- W4280644894 cites W2170026872 @default.
- W4280644894 cites W2176663520 @default.
- W4280644894 cites W2192080449 @default.
- W4280644894 cites W2207753479 @default.
- W4280644894 cites W2269004269 @default.
- W4280644894 cites W2287743229 @default.
- W4280644894 cites W2405329180 @default.
- W4280644894 cites W2407372765 @default.
- W4280644894 cites W2410883407 @default.
- W4280644894 cites W2419371430 @default.
- W4280644894 cites W2432059528 @default.