FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4280647518> ?p ?o ?g. }

• W4280647518 abstract "<h2>Abstract</h2><h3>Aims</h3> Inclusion of the internal mammary chain in the radiotherapy target volume (IMC-RT) improves disease-free and overall survival in higher risk breast cancer patients, but increases radiation doses to heart and lungs. Dosimetric data show that either modified wide-tangential fields (WT) or volumetric modulated arc therapy (VMAT) together with [AQ1]voluntary deep inspiration breath hold (vDIBH) keep mean heart doses below 4 Gy in most patients. However, the impact on departmental resources has not yet been documented. This phase II clinical trial compared the time taken to deliver IMC-RT using either WT and vDIBH or VMAT and vDIBH, together with planning time, dosimetry, set-up reproducibility and toxicity. <h3>Materials and methods</h3> Left-sided breast cancer patients requiring IMC-RT were randomised to receive either WT(vDIBH) or VMAT radiotherapy. The primary outcome was treatment time, powered to detect a minimum difference of 75 min (5 min/fraction) between techniques. The population mean displacement, systematic error and random error for cone beam computed tomography chest wall matches in three directions of movement were calculated. Target volume and organ at risk doses were compared between groups. Side-effects, including skin (Radiation Therapy Oncology Group), lung and oesophageal toxicity (Common Terminology Criteria for Adverse Events v 4.03) rates, were compared between the groups over 3 months. Patient-reported outcome measures, including shoulder toxicity at baseline, 6 months and 1 year, were compared. <h3>Results</h3> Twenty-one patients were recruited from a single UK centre between February 2017 and January 2018. The mean (standard deviation) total treatment time per fraction for VMAT treatments was 13.2 min (1.7 min) compared with 28.1 min (3.3 min) for WT(vDIBH). There were no statistically significant differences in patient set-up errors in between groups. The average mean heart dose for WT(vDIBH) was 2.6 Gy compared with 3.4 Gy for VMAT(vDIBH) (<i>P</i> = 0.13). The mean ipsilateral lung V_17Gy was 32.8% in the WT(vDIBH) group versus 34.4% in the VMAT group (<i>P</i> = 0.2). The humeral head (mean dose 16.8 Gy versus 2.8 Gy), oesophagus (maximum dose 37.3 Gy versus 20.1 Gy) and thyroid (mean dose 22.0 Gy versus 11.2 Gy) all received a statistically significantly higher dose in the VMAT group. There were no statistically significant differences in skin, lung or oesophageal toxicity within 3 months of treatment. Patient-reported outcomes of shoulder toxicity, pain, fatigue, breathlessness and breast symptoms were similar between groups at 1 year. <h3>Conclusion</h3> VMAT(vDIBH) and WT(vDIBH) are feasible options for locoregional breast radiotherapy including the IMC. VMAT improves nodal coverage and delivers treatment more quickly, resulting in less breath holds for the patient. This is at the cost of increased dose to some non-target tissues. The latter does not appear to translate into increased toxicity in this small study." @default.
• W4280647518 created "2022-05-22" @default.
• W4280647518 creator A5007642367 @default.
• W4280647518 creator A5021891658 @default.
• W4280647518 creator A5036027629 @default.
• W4280647518 creator A5038283257 @default.
• W4280647518 creator A5055460282 @default.
• W4280647518 creator A5055601505 @default.
• W4280647518 creator A5065713063 @default.
• W4280647518 creator A5082678304 @default.
• W4280647518 creator A5085526587 @default.
• W4280647518 creator A5087404472 @default.
• W4280647518 date "2022-05-01" @default.
• W4280647518 modified "2023-10-14" @default.
• W4280647518 title "A Randomised Phase II Clinical Trial Comparing the Deliverability and Acute Toxicity of Wide Tangent versus Volumetric Modulated Arc Therapy to the Breast and Internal Mammary Chain" @default.
• W4280647518 cites W1770259999 @default.
• W4280647518 cites W2016353779 @default.
• W4280647518 cites W2020018891 @default.
• W4280647518 cites W2033920439 @default.
• W4280647518 cites W2062616726 @default.
• W4280647518 cites W2091312274 @default.
• W4280647518 cites W2117408044 @default.
• W4280647518 cites W2122062060 @default.
• W4280647518 cites W2149690332 @default.
• W4280647518 cites W2150553852 @default.
• W4280647518 cites W2154375587 @default.
• W4280647518 cites W2156838976 @default.
• W4280647518 cites W2176010689 @default.
• W4280647518 cites W2788151071 @default.
• W4280647518 cites W2937127896 @default.
• W4280647518 cites W2943776193 @default.
• W4280647518 cites W2971622014 @default.
• W4280647518 cites W3131429396 @default.
• W4280647518 cites W993406450 @default.
• W4280647518 doi "https://doi.org/10.1016/j.clon.2022.03.020" @default.
• W4280647518 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35597698" @default.
• W4280647518 hasPublicationYear "2022" @default.
• W4280647518 type Work @default.
• W4280647518 citedByCount "0" @default.
• W4280647518 crossrefType "journal-article" @default.
• W4280647518 hasAuthorship W4280647518A5007642367 @default.
• W4280647518 hasAuthorship W4280647518A5021891658 @default.
• W4280647518 hasAuthorship W4280647518A5036027629 @default.
• W4280647518 hasAuthorship W4280647518A5038283257 @default.
• W4280647518 hasAuthorship W4280647518A5055460282 @default.
• W4280647518 hasAuthorship W4280647518A5055601505 @default.
• W4280647518 hasAuthorship W4280647518A5065713063 @default.
• W4280647518 hasAuthorship W4280647518A5082678304 @default.
• W4280647518 hasAuthorship W4280647518A5085526587 @default.
• W4280647518 hasAuthorship W4280647518A5087404472 @default.
• W4280647518 hasConcept C121608353 @default.
• W4280647518 hasConcept C126322002 @default.
• W4280647518 hasConcept C141071460 @default.
• W4280647518 hasConcept C155806632 @default.
• W4280647518 hasConcept C197934379 @default.
• W4280647518 hasConcept C201645570 @default.
• W4280647518 hasConcept C2777793932 @default.
• W4280647518 hasConcept C2908647359 @default.
• W4280647518 hasConcept C29730261 @default.
• W4280647518 hasConcept C2989005 @default.
• W4280647518 hasConcept C509974204 @default.
• W4280647518 hasConcept C530470458 @default.
• W4280647518 hasConcept C535046627 @default.
• W4280647518 hasConcept C71924100 @default.
• W4280647518 hasConcept C75088862 @default.
• W4280647518 hasConcept C99454951 @default.
• W4280647518 hasConceptScore W4280647518C121608353 @default.
• W4280647518 hasConceptScore W4280647518C126322002 @default.
• W4280647518 hasConceptScore W4280647518C141071460 @default.
• W4280647518 hasConceptScore W4280647518C155806632 @default.
• W4280647518 hasConceptScore W4280647518C197934379 @default.
• W4280647518 hasConceptScore W4280647518C201645570 @default.
• W4280647518 hasConceptScore W4280647518C2777793932 @default.
• W4280647518 hasConceptScore W4280647518C2908647359 @default.
• W4280647518 hasConceptScore W4280647518C29730261 @default.
• W4280647518 hasConceptScore W4280647518C2989005 @default.
• W4280647518 hasConceptScore W4280647518C509974204 @default.
• W4280647518 hasConceptScore W4280647518C530470458 @default.
• W4280647518 hasConceptScore W4280647518C535046627 @default.
• W4280647518 hasConceptScore W4280647518C71924100 @default.
• W4280647518 hasConceptScore W4280647518C75088862 @default.
• W4280647518 hasConceptScore W4280647518C99454951 @default.
• W4280647518 hasLocation W42806475181 @default.
• W4280647518 hasLocation W42806475182 @default.
• W4280647518 hasOpenAccess W4280647518 @default.
• W4280647518 hasPrimaryLocation W42806475181 @default.
• W4280647518 hasRelatedWork W1132082835 @default.
• W4280647518 hasRelatedWork W1919433043 @default.
• W4280647518 hasRelatedWork W2044564816 @default.
• W4280647518 hasRelatedWork W2144622085 @default.
• W4280647518 hasRelatedWork W2186742268 @default.
• W4280647518 hasRelatedWork W3030063216 @default.
• W4280647518 hasRelatedWork W3031152052 @default.
• W4280647518 hasRelatedWork W3146372209 @default.
• W4280647518 hasRelatedWork W4307146680 @default.
• W4280647518 hasRelatedWork W4307349053 @default.
• W4280647518 isParatext "false" @default.
• W4280647518 isRetracted "false" @default.
• W4280647518 workType "article" @default.