Matches in SemOpenAlex for { <https://semopenalex.org/work/W4280652009> ?p ?o ?g. }
- W4280652009 abstract "Although stromal fibroblasts play a critical role in cancer progression, their identities remain unclear as they exhibit high heterogeneity and plasticity. Here, a master transcription factor (mTF) constructing core-regulatory circuitry, PRRX1, which determines the fibroblast lineage with a myofibroblastic phenotype, is identified for the fibroblast subgroup. PRRX1 orchestrates the functional drift of fibroblasts into myofibroblastic phenotype via TGF-β signaling by remodeling a super-enhancer landscape. Such reprogrammed fibroblasts have myofibroblastic functions resulting in markedly enhanced tumorigenicity and aggressiveness of cancer. PRRX1 expression in cancer-associated fibroblast (CAF) has an unfavorable prognosis in multiple cancer types. Fibroblast-specific PRRX1 depletion induces long-term and sustained complete remission of chemotherapy-resistant cancer in genetically engineered mice models. This study reveals CAF subpopulations based on super-enhancer profiles including PRRX1. Therefore, mTFs, including PRRX1, provide another opportunity for establishing a hierarchical classification system of fibroblasts and cancer treatment by targeting fibroblasts." @default.
- W4280652009 created "2022-05-22" @default.
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- W4280652009 date "2022-05-19" @default.
- W4280652009 modified "2023-10-15" @default.
- W4280652009 title "PRRX1 is a master transcription factor of stromal fibroblasts for myofibroblastic lineage progression" @default.
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- W4280652009 doi "https://doi.org/10.1038/s41467-022-30484-4" @default.
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