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• W4280653606 startingPage "108523" @default.
• W4280653606 abstract "Hearing loss affects more than 430 million people, worldwide, and is the third most common chronic physical condition in the United States and Europe (GBD Hearing Loss Collaborators, 2021; NIOSH, 2021; WHO, 2021). The loss of hearing significantly impacts motor and cognitive development, communication, education, employment, and overall quality of life. The inner ear houses the sensory organs for both hearing and balance and provides an accessible target for therapeutic delivery. Antisense oligonucleotides (ASOs) use various mechanisms to manipulate gene expression and can be tailor-made to treat disorders with defined genetic targets. In this review, we discuss the preclinical advancements within the field of the highly promising ASO-based therapies for hereditary hearing loss disorders. Particular focus is on ASO mechanisms of action, preclinical studies on ASO treatments of hearing loss, timing of therapeutic intervention, and delivery routes to the inner ear." @default.
• W4280653606 created "2022-05-22" @default.
• W4280653606 creator A5000563716 @default.
• W4280653606 creator A5018973964 @default.
• W4280653606 creator A5048222303 @default.
• W4280653606 creator A5050915545 @default.
• W4280653606 date "2022-12-01" @default.
• W4280653606 modified "2023-10-18" @default.
• W4280653606 title "Altering gene expression using antisense oligonucleotide therapy for hearing loss" @default.
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