FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4281253487> ?p ?o ?g. }

• W4281253487 abstract "Cell-cell fusion is important for biological processes including fertilization, development, immunity, and microbial pathogenesis. Bacteria in the pseudomallei group of the Burkholderia species, including B. thailandensis, spread between host cells by inducing cell-cell fusion. Previous work showed that B. thailandensis-induced cell-cell fusion requires intracellular bacterial motility and a bacterial protein secretion apparatus called the type VI secretion system-5 (T6SS-5), including the T6SS-5 protein VgrG5. However, the cellular-level mechanism of and T6SS-5 proteins important for bacteria-induced cell-cell fusion remained incompletely described. Using live-cell imaging, we found bacteria used actin-based motility to push on the host cell plasma membrane to form plasma membrane protrusions that extended into neighboring cells. Then, membrane fusion occurred within membrane protrusions either proximal to the bacterium at the tip or elsewhere within protrusions. Expression of VgrG5 by bacteria within membrane protrusions was required to promote cell-cell fusion. Furthermore, a second predicted T6SS-5 protein, TagD5, was also required for cell-cell fusion. In the absence of VgrG5 or TagD5, bacteria in plasma membrane protrusions were engulfed into neighboring cells. Our results suggest that the T6SS-5 effectors VgrG5 and TagD5 are secreted within membrane protrusions and act locally to promote membrane fusion." @default.
• W4281253487 created "2022-05-23" @default.
• W4281253487 creator A5041986810 @default.
• W4281253487 creator A5075374778 @default.
• W4281253487 date "2022-07-01" @default.
• W4281253487 modified "2023-10-14" @default.
• W4281253487 title "Plasma membrane protrusions mediate host cell–cell fusion induced by <i>Burkholderia thailandensis</i>" @default.
• W4281253487 cites W1558730833 @default.
• W4281253487 cites W1568956298 @default.
• W4281253487 cites W1970786682 @default.
• W4281253487 cites W1972038449 @default.
• W4281253487 cites W1983624699 @default.
• W4281253487 cites W1995736892 @default.
• W4281253487 cites W1998279163 @default.
• W4281253487 cites W1998523743 @default.
• W4281253487 cites W2007230387 @default.
• W4281253487 cites W2007960706 @default.
• W4281253487 cites W2010587391 @default.
• W4281253487 cites W2013704433 @default.
• W4281253487 cites W2050803324 @default.
• W4281253487 cites W2051446362 @default.
• W4281253487 cites W2084707381 @default.
• W4281253487 cites W2092673939 @default.
• W4281253487 cites W2096618434 @default.
• W4281253487 cites W2106816433 @default.
• W4281253487 cites W2108920131 @default.
• W4281253487 cites W2111011993 @default.
• W4281253487 cites W2111051291 @default.
• W4281253487 cites W2112570744 @default.
• W4281253487 cites W2113428334 @default.
• W4281253487 cites W2117411464 @default.
• W4281253487 cites W2121297944 @default.
• W4281253487 cites W2123151328 @default.
• W4281253487 cites W2125870848 @default.
• W4281253487 cites W2128007785 @default.
• W4281253487 cites W2131599797 @default.
• W4281253487 cites W2132173376 @default.
• W4281253487 cites W2140772054 @default.
• W4281253487 cites W2152627116 @default.
• W4281253487 cites W2165731733 @default.
• W4281253487 cites W2167472314 @default.
• W4281253487 cites W2168484570 @default.
• W4281253487 cites W2168737114 @default.
• W4281253487 cites W2169014218 @default.
• W4281253487 cites W2219826623 @default.
• W4281253487 cites W2308645382 @default.
• W4281253487 cites W2413295697 @default.
• W4281253487 cites W2521778684 @default.
• W4281253487 cites W2537143620 @default.
• W4281253487 cites W2563711991 @default.
• W4281253487 cites W2777800236 @default.
• W4281253487 cites W2889246734 @default.
• W4281253487 cites W2909492713 @default.
• W4281253487 cites W2956045400 @default.
• W4281253487 cites W2964247637 @default.
• W4281253487 cites W2969688880 @default.
• W4281253487 cites W2974506595 @default.
• W4281253487 cites W3027647734 @default.
• W4281253487 cites W3084071956 @default.
• W4281253487 cites W3106059749 @default.
• W4281253487 cites W3117197773 @default.
• W4281253487 cites W4211093779 @default.
• W4281253487 doi "https://doi.org/10.1091/mbc.e22-02-0056" @default.
• W4281253487 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35594178" @default.
• W4281253487 hasPublicationYear "2022" @default.
• W4281253487 type Work @default.
• W4281253487 citedByCount "1" @default.
• W4281253487 countsByYear W42812534872023 @default.
• W4281253487 crossrefType "journal-article" @default.
• W4281253487 hasAuthorship W4281253487A5041986810 @default.
• W4281253487 hasAuthorship W4281253487A5075374778 @default.
• W4281253487 hasBestOaLocation W42812534872 @default.
• W4281253487 hasConcept C103038307 @default.
• W4281253487 hasConcept C1491633281 @default.
• W4281253487 hasConcept C173414695 @default.
• W4281253487 hasConcept C2778106830 @default.
• W4281253487 hasConcept C41625074 @default.
• W4281253487 hasConcept C49039625 @default.
• W4281253487 hasConcept C55493867 @default.
• W4281253487 hasConcept C79879829 @default.
• W4281253487 hasConcept C86803240 @default.
• W4281253487 hasConcept C89423630 @default.
• W4281253487 hasConcept C92488253 @default.
• W4281253487 hasConcept C95444343 @default.
• W4281253487 hasConceptScore W4281253487C103038307 @default.
• W4281253487 hasConceptScore W4281253487C1491633281 @default.
• W4281253487 hasConceptScore W4281253487C173414695 @default.
• W4281253487 hasConceptScore W4281253487C2778106830 @default.
• W4281253487 hasConceptScore W4281253487C41625074 @default.
• W4281253487 hasConceptScore W4281253487C49039625 @default.
• W4281253487 hasConceptScore W4281253487C55493867 @default.
• W4281253487 hasConceptScore W4281253487C79879829 @default.
• W4281253487 hasConceptScore W4281253487C86803240 @default.
• W4281253487 hasConceptScore W4281253487C89423630 @default.
• W4281253487 hasConceptScore W4281253487C92488253 @default.
• W4281253487 hasConceptScore W4281253487C95444343 @default.
• W4281253487 hasIssue "8" @default.
• W4281253487 hasLocation W42812534871 @default.
• W4281253487 hasLocation W42812534872 @default.
• W4281253487 hasLocation W42812534873 @default.

• next