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• W4281255933 abstract "The design of mesoporous silica nanoparticles (MSNs) for drug delivery is attracting increasing interest. Controlled release of their cargo is usually mediated by diffusion and erosion mechanisms, which might not reach the expected therapeutic effects. Here, we report the development and characterization of MSNs which modulate the cargo release in different cell models: fibroblasts and embryonic stem cells. Based on a double strategy: the presence of multimodal pore channels and a chitosan coating, we demonstrated a modulated release. Our results show that MSNs could be used for controlled drug delivery in different cell types, showing the potential of improving pluripotent stem cells differentiation and reprogramming protocols with promising applications in biomedicine." @default.
• W4281255933 created "2022-05-23" @default.
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• W4281255933 date "2022-07-01" @default.
• W4281255933 modified "2023-10-13" @default.
• W4281255933 title "Design of silica nanocarriers: Tuning the release to embryonic stem cells by simple strategies" @default.
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• W4281255933 doi "https://doi.org/10.1016/j.jbiotec.2022.05.008" @default.
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