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- W4281258363 abstract "Finding the causal relation between a gene and a disease using experimental approaches is a time-consuming and expensive task. However, computational approaches are cost-efficient methods for identifying candidate genes. This article proposes a new heterogeneous biological network embedding approach, named NetEM, to identify disease-associated genes. To evaluate NetEM, we examine six complex diseases, including peroxisomal disorders, sarcoma, grave's disease, lysosomal storage diseases, blood coagulation disorders, and cardiomyopathy hypertrophic. Our experiments indicate that NetEM outperforms three well-known state-of-the-art algorithms: Cardigan, DIAMOnD and GeneWanderer, in identifying disease genes. We examine TCGA data of Invasive Lobular Breast Cancer and CPTAC data of human glioblastoma as other case studies to evaluate NetEM using real data. This evaluation also indicates the validity of the method. The source codes of NetEM and data are available in the supplementary of this article." @default.
- W4281258363 created "2022-05-23" @default.
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- W4281258363 date "2023-03-01" @default.
- W4281258363 modified "2023-09-27" @default.
- W4281258363 title "Complex Disease Genes Identification Using a Heterogeneous Network Embedding Approach" @default.
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- W4281258363 doi "https://doi.org/10.1109/tcbb.2022.3175598" @default.
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