Matches in SemOpenAlex for { <https://semopenalex.org/work/W4281260863> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W4281260863 endingPage "130" @default.
- W4281260863 startingPage "123" @default.
- W4281260863 abstract "Cancer patients often require a titanium orthopaedic implant to support or replace lost bone. In radiation treatment, the dose distribution is perturbed causing regions of high and low dose at material interfaces. Since the survival of integrating bone tissue is critical to implant success, the aim of this study was to determine the dose distribution in and around the scaffold, when constructed from titanium or Poly-ether-ether-ketone (PEEK).The dose distributions in the pores and along boundaries for three implant scaffold designs were calculated using Monte-Carlo methods in Geant4/GATE, with the material taken as titanium or PEEK. The 3D dose distributions were analysed in MATLAB and segmented using image masks, yielding the dose distributions in key regions of interest. To evaluate the effect of the predicted dose perturbations, the cell survival was calculated using the linear-quadratic model for SAOS-2 cells (bone) using experimentally determined radiation response data.High dose gradients were found along the boundaries of the titanium implants, but not for the corresponding PEEK implants. The dose to the internal cavities of the titanium implants was enhanced by 10-15% near the proximal interface whereas for PEEK, there was no significant dose perturbation. The predicted perturbation caused by the titanium implant was shown to decrease the survival for SAOS-2 cells by 7% which was not found for the PEEK implants.PEEK was shown to be a more favourable orthopaedic implant material over titanium for cancer patients considering radiation therapy." @default.
- W4281260863 created "2022-05-23" @default.
- W4281260863 creator A5026205344 @default.
- W4281260863 creator A5046337338 @default.
- W4281260863 creator A5046816795 @default.
- W4281260863 date "2022-04-01" @default.
- W4281260863 modified "2023-09-26" @default.
- W4281260863 title "Monte Carlo calculations of radiotherapy dose distributions within and around orthopaedic implants" @default.
- W4281260863 cites W115107697 @default.
- W4281260863 cites W1932330099 @default.
- W4281260863 cites W2007417719 @default.
- W4281260863 cites W2032590953 @default.
- W4281260863 cites W2045821685 @default.
- W4281260863 cites W2063038041 @default.
- W4281260863 cites W2111645718 @default.
- W4281260863 cites W2120803591 @default.
- W4281260863 cites W2128158076 @default.
- W4281260863 cites W2128900400 @default.
- W4281260863 cites W2158162507 @default.
- W4281260863 cites W2168458302 @default.
- W4281260863 cites W2169345696 @default.
- W4281260863 cites W2229004234 @default.
- W4281260863 cites W2314008283 @default.
- W4281260863 cites W2416516440 @default.
- W4281260863 cites W2595465282 @default.
- W4281260863 cites W2630972394 @default.
- W4281260863 cites W2781936857 @default.
- W4281260863 cites W2904929985 @default.
- W4281260863 cites W2913035035 @default.
- W4281260863 cites W2914334624 @default.
- W4281260863 cites W2992630144 @default.
- W4281260863 cites W3030192215 @default.
- W4281260863 doi "https://doi.org/10.1016/j.phro.2022.04.011" @default.
- W4281260863 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35619642" @default.
- W4281260863 hasPublicationYear "2022" @default.
- W4281260863 type Work @default.
- W4281260863 citedByCount "2" @default.
- W4281260863 countsByYear W42812608632023 @default.
- W4281260863 crossrefType "journal-article" @default.
- W4281260863 hasAuthorship W4281260863A5026205344 @default.
- W4281260863 hasAuthorship W4281260863A5046337338 @default.
- W4281260863 hasAuthorship W4281260863A5046816795 @default.
- W4281260863 hasBestOaLocation W42812608631 @default.
- W4281260863 hasConcept C105795698 @default.
- W4281260863 hasConcept C136229726 @default.
- W4281260863 hasConcept C141071460 @default.
- W4281260863 hasConcept C159985019 @default.
- W4281260863 hasConcept C191897082 @default.
- W4281260863 hasConcept C192562407 @default.
- W4281260863 hasConcept C19499675 @default.
- W4281260863 hasConcept C2781411149 @default.
- W4281260863 hasConcept C33923547 @default.
- W4281260863 hasConcept C506065880 @default.
- W4281260863 hasConcept C521977710 @default.
- W4281260863 hasConcept C71924100 @default.
- W4281260863 hasConcept C7660682 @default.
- W4281260863 hasConceptScore W4281260863C105795698 @default.
- W4281260863 hasConceptScore W4281260863C136229726 @default.
- W4281260863 hasConceptScore W4281260863C141071460 @default.
- W4281260863 hasConceptScore W4281260863C159985019 @default.
- W4281260863 hasConceptScore W4281260863C191897082 @default.
- W4281260863 hasConceptScore W4281260863C192562407 @default.
- W4281260863 hasConceptScore W4281260863C19499675 @default.
- W4281260863 hasConceptScore W4281260863C2781411149 @default.
- W4281260863 hasConceptScore W4281260863C33923547 @default.
- W4281260863 hasConceptScore W4281260863C506065880 @default.
- W4281260863 hasConceptScore W4281260863C521977710 @default.
- W4281260863 hasConceptScore W4281260863C71924100 @default.
- W4281260863 hasConceptScore W4281260863C7660682 @default.
- W4281260863 hasLocation W42812608631 @default.
- W4281260863 hasLocation W42812608632 @default.
- W4281260863 hasLocation W42812608633 @default.
- W4281260863 hasOpenAccess W4281260863 @default.
- W4281260863 hasPrimaryLocation W42812608631 @default.
- W4281260863 hasRelatedWork W1971146544 @default.
- W4281260863 hasRelatedWork W1986199704 @default.
- W4281260863 hasRelatedWork W2020108824 @default.
- W4281260863 hasRelatedWork W2050042332 @default.
- W4281260863 hasRelatedWork W2075883544 @default.
- W4281260863 hasRelatedWork W2138954365 @default.
- W4281260863 hasRelatedWork W2350278514 @default.
- W4281260863 hasRelatedWork W2898354355 @default.
- W4281260863 hasRelatedWork W4298086698 @default.
- W4281260863 hasRelatedWork W4313198608 @default.
- W4281260863 hasVolume "22" @default.
- W4281260863 isParatext "false" @default.
- W4281260863 isRetracted "false" @default.
- W4281260863 workType "article" @default.