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- W4281262054 abstract "A baby was born via urgent cesarean section at 37 + 4 weeks of gestation, with hypoxic-ischemic encephalopathy (HIE). Amplitude-integrated electroencephalography (aEEG) and therapeutic hypothermia were initiated 2 h after birth. An episode of generalized tonic-clonic seizures occurred during the first day of life (DoL) and was treated with phenobarbital. The patient developed a transient blanchable erythematous rash on the right side (from the face to the foot) on the third DoL with a clear demarcation line separating each side of the body (Fig. 1). Simultaneously, aEEG indicated seizure activity; a midazolam bolus was injected leading to the resolution of the seizure and rash within 10 min, and no other events occurred. This cutaneous phenomenon is called Harlequin syndrome (HS), which is a rare autonomic dysfunction, and extremely rare in cases of HIE. An idiopathic etiology is the more frequent cause but other possible causes are iatrogenic lesions, central nervous system infection, autoimmune disease, prostaglandin E1 or anesthetic infusion, or hypoxia [1Januário G. Salgado M. The Harlequin phenomenon.J Eur Acad Dermatol Venereol. 2011; 25: 1381-1384Crossref PubMed Scopus (11) Google Scholar, 2Kang J.H. Shahzad Zafar M. Werner K.E. Child Neurology: an infant with episodic facial flushing: A rare case and review of congenital harlequin syndrome.Neurology. 2018; 91: 278-281Crossref PubMed Scopus (6) Google Scholar, 3Valerio E. Barlotta A. Lorenzon E. Antonazzo L. Cutrone M. Harlequin color change: neonatal case series and brief literature review.AJP Rep. 2015; 5: e73-e76PubMed Google Scholar]. In our case, a brain magnetic resonance image taken on Day 7 revealed multiple microhemorrhages in the falx cerebri and the subdural and subarachnoid spaces. Neurological development at 3, 6, and 12 months was normal. Thus, HS is an epiphenomenon with central nervous system involvement that needs further investigation. This study received no funding." @default.
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- W4281262054 date "2022-11-01" @default.
- W4281262054 modified "2023-10-18" @default.
- W4281262054 title "Harlequin phenomenon in a newborn" @default.
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- W4281262054 doi "https://doi.org/10.1016/j.pedneo.2022.04.006" @default.
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