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• W4281263670 abstract "La psoriasis es una enfermedad que va más allá de la afectación exclusivamente cutánea, cada día se reconoce más la importancia del compromiso sistémico, en especial por las comorbilidades asociadas. Dichas comorbilidades se explican por la marcada respuesta inflamatoria sistémica crónica mediada por citoquinas proinflamatorias (principalmente TNF-α, IL-23 e IL-17), las cuales desempeñan un papel importante en la inducción de la resistencia a la insulina, la disfunción endotelial, la aterosclerosis acelerada y el aumento del riesgo de eventos cardio-cerebrovasculares. La relación con estos desenlaces ha sido demostrada, y es allí donde surge el concepto de marcha psoriásica, un término que cobra cada día más importancia, cuyo objetivo es mantener y reforzar el enfoque de una enfermedad cutánea con compromiso sistémico, morbimortalidad asociada que puede ser prevenible y manejable. Los mecanismos fisiopatológicos que explican estos fenómenos son variables, sin embargo, se han dilucidado nuevos conceptos que han permitido mejorar el enfoque actual de la enfermedad, y así establecer mecanismos para disminuir el riesgo cardiovascular en pacientes con psoriasis. Psoriasis is a disease that is not limited to skin involvement, the importance of systemic compromise is recognized more than ever, especially because of the associated comorbidities, which are explained by the marked chronic systemic inflammatory response mediated by pro-inflammatory cytokines (mainly TNF-α, IL23, IL 17), which play an important role in the induction of insulin resistance, endothelial dysfunction, accelerated atherosclerosis and the increased risk of cardio-cerebrovascular events. The relationship with these outcomes has been demonstrated and hence the concept of psoriatic march, a term that is gaining increasing importance aimed at maintaining and reinforcing the approach to a skin disease with systemic compromise, associated morbidity and mortality that can be preventable and manageable. The pathophysiological mechanisms that explain these phenomena are variable, however, new concepts have been identified, which have made it possible to improve the current approach to the disease and thus establish mechanisms to reduce cardiovascular risk in patients with psoriasis." @default.
• W4281263670 created "2022-05-23" @default.
• W4281263670 creator A5072612318 @default.
• W4281263670 creator A5081461013 @default.
• W4281263670 creator A5088751051 @default.
• W4281263670 date "2022-05-01" @default.
• W4281263670 modified "2023-09-27" @default.
• W4281263670 title "Marcha psoriásica: una mirada desde la fisiopatología hasta el riesgo cardiovascular" @default.
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• W4281263670 doi "https://doi.org/10.1016/j.rcreu.2022.03.006" @default.
• W4281263670 hasPublicationYear "2022" @default.

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