Matches in SemOpenAlex for { <https://semopenalex.org/work/W4281286410> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W4281286410 abstract "Background and objectives: Exosomes therapy is a promising technique that can decrease the concern related to the fate of transplanted stem cells to the fistula location. The unique properties of mesenchymal stem cells (MSCs)-derived exosomes can improve fistula healing because of their high ability to regulate and modify immune responses. This project aims to examine the safety and efficacy of implementing MSCs-exosomes in treating refractory fistulas in inflammatory bowel disease (IBD) patients. Methods : The exosomes were isolated from umbilical cord-derived MSCs and characterized using flow cytometry, western blotting, and transmittance electron microscope (TEM). Five patients (three men and two women) with refractory perianal Crohn’s disease with an average age of 35.4 years old were included. The patients did not match the exclusion criteria, and the presence of refractory fistulas was the main inclusion criteria. These patients have their exosomes injections in the operation room. The therapy responses of patients were assessed using physical examination, face-to-face interviews, computerized tomography (CT) scan, and magnetic resonance imaging (MRI) six months later. Result : The Following injection, patients reported a 70% improvement on average. Two patients claimed complete healing after exosome injections, while one patient reported no improvement and active discharge from the fistula site. In addition, five patients reported no adverse effects, both systemic or on the injection site. Conclusion : Injection of exosomes extracted from MSCs shows total safety and a satisfactory therapeutic impact, as shown in this and other research, and could play a significant role in the treatment of gastrointestinal fistulas in the future." @default.
- W4281286410 created "2022-05-24" @default.
- W4281286410 creator A5005372902 @default.
- W4281286410 creator A5030078140 @default.
- W4281286410 creator A5042628601 @default.
- W4281286410 creator A5044819097 @default.
- W4281286410 creator A5045242725 @default.
- W4281286410 creator A5047670071 @default.
- W4281286410 creator A5053090647 @default.
- W4281286410 creator A5054062364 @default.
- W4281286410 creator A5054217642 @default.
- W4281286410 creator A5055519358 @default.
- W4281286410 creator A5085731647 @default.
- W4281286410 creator A5089212665 @default.
- W4281286410 date "2022-05-23" @default.
- W4281286410 modified "2023-09-23" @default.
- W4281286410 title "Evaluating the Safety and Efficacy of MSCs-derived Exosomes for Treatment of Resistant Perianal Fistula in IBD patients; Clinical Trial Phase I " @default.
- W4281286410 doi "https://doi.org/10.22541/au.165331448.86279768/v1" @default.
- W4281286410 hasPublicationYear "2022" @default.
- W4281286410 type Work @default.
- W4281286410 citedByCount "0" @default.
- W4281286410 crossrefType "posted-content" @default.
- W4281286410 hasAuthorship W4281286410A5005372902 @default.
- W4281286410 hasAuthorship W4281286410A5030078140 @default.
- W4281286410 hasAuthorship W4281286410A5042628601 @default.
- W4281286410 hasAuthorship W4281286410A5044819097 @default.
- W4281286410 hasAuthorship W4281286410A5045242725 @default.
- W4281286410 hasAuthorship W4281286410A5047670071 @default.
- W4281286410 hasAuthorship W4281286410A5053090647 @default.
- W4281286410 hasAuthorship W4281286410A5054062364 @default.
- W4281286410 hasAuthorship W4281286410A5054217642 @default.
- W4281286410 hasAuthorship W4281286410A5055519358 @default.
- W4281286410 hasAuthorship W4281286410A5085731647 @default.
- W4281286410 hasAuthorship W4281286410A5089212665 @default.
- W4281286410 hasBestOaLocation W42812864101 @default.
- W4281286410 hasConcept C104317684 @default.
- W4281286410 hasConcept C121332964 @default.
- W4281286410 hasConcept C126322002 @default.
- W4281286410 hasConcept C126838900 @default.
- W4281286410 hasConcept C141071460 @default.
- W4281286410 hasConcept C142424586 @default.
- W4281286410 hasConcept C142724271 @default.
- W4281286410 hasConcept C143409427 @default.
- W4281286410 hasConcept C145059251 @default.
- W4281286410 hasConcept C185592680 @default.
- W4281286410 hasConcept C197934379 @default.
- W4281286410 hasConcept C198826908 @default.
- W4281286410 hasConcept C20518536 @default.
- W4281286410 hasConcept C2776341189 @default.
- W4281286410 hasConcept C2781261824 @default.
- W4281286410 hasConcept C535046627 @default.
- W4281286410 hasConcept C55493867 @default.
- W4281286410 hasConcept C71924100 @default.
- W4281286410 hasConcept C87355193 @default.
- W4281286410 hasConceptScore W4281286410C104317684 @default.
- W4281286410 hasConceptScore W4281286410C121332964 @default.
- W4281286410 hasConceptScore W4281286410C126322002 @default.
- W4281286410 hasConceptScore W4281286410C126838900 @default.
- W4281286410 hasConceptScore W4281286410C141071460 @default.
- W4281286410 hasConceptScore W4281286410C142424586 @default.
- W4281286410 hasConceptScore W4281286410C142724271 @default.
- W4281286410 hasConceptScore W4281286410C143409427 @default.
- W4281286410 hasConceptScore W4281286410C145059251 @default.
- W4281286410 hasConceptScore W4281286410C185592680 @default.
- W4281286410 hasConceptScore W4281286410C197934379 @default.
- W4281286410 hasConceptScore W4281286410C198826908 @default.
- W4281286410 hasConceptScore W4281286410C20518536 @default.
- W4281286410 hasConceptScore W4281286410C2776341189 @default.
- W4281286410 hasConceptScore W4281286410C2781261824 @default.
- W4281286410 hasConceptScore W4281286410C535046627 @default.
- W4281286410 hasConceptScore W4281286410C55493867 @default.
- W4281286410 hasConceptScore W4281286410C71924100 @default.
- W4281286410 hasConceptScore W4281286410C87355193 @default.
- W4281286410 hasLocation W42812864101 @default.
- W4281286410 hasOpenAccess W4281286410 @default.
- W4281286410 hasPrimaryLocation W42812864101 @default.
- W4281286410 hasRelatedWork W2757109498 @default.
- W4281286410 hasRelatedWork W2892744778 @default.
- W4281286410 hasRelatedWork W2955875101 @default.
- W4281286410 hasRelatedWork W3005218979 @default.
- W4281286410 hasRelatedWork W3009964850 @default.
- W4281286410 hasRelatedWork W3128273902 @default.
- W4281286410 hasRelatedWork W3128585320 @default.
- W4281286410 hasRelatedWork W3198772284 @default.
- W4281286410 hasRelatedWork W4288037568 @default.
- W4281286410 hasRelatedWork W4302438514 @default.
- W4281286410 isParatext "false" @default.
- W4281286410 isRetracted "false" @default.
- W4281286410 workType "article" @default.