FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4281287750> ?p ?o ?g. }

• W4281287750 endingPage "518" @default.
• W4281287750 startingPage "510" @default.
• W4281287750 abstract "Antenatal antiviral therapy (AVT) is effective in preventing mother-to-child transmission (MTCT) in chronic hepatitis B (CHB); tenofovir disoproxil fumarate (TDF) is the preferred agent. Tenofovir alafenamide (TAF) is a prodrug of tenofovir (TFV) similar to TDF, with improved bone and renal safety. There are no data on TAF breast milk pharmacokinetics and exposure to breastfeeding infants in CHB.To assess the pharmacokinetics of TAF/TFV in breastfeeding women with CHB on TAF monotherapy.Pregnant women with CHB requiring AVT commenced TAF 25 mg daily at third trimester or postpartum. Sample collection occurred while breastfeeding and taking TAF for minimum 4 weeks. Maternal blood, breast milk and infant urine samples were collected. Drug concentrations were measured by LCMS/MS analyses using validated methods. Non-compartmental analyses were performed to quantify the pharmacokinetic parameters.Eight women provided samples. In breast milk and plasma, median TAF half-life was 0.81 and 0.94 h, respectively, and Cmax 1.69 and 120.5 ng/ml, respectively. Median maternal breast milk to plasma (M/P) ratio of TAF was 0.029; for and TFV it was 2.809. The relative infant dose of TAF was 0.005% of maternal dose, well below safety threshold of 5-10%. TFV was detectable in three out of seven infant urine samples with median steady-state concentration of 5 ng/ml being 300-2500 times less than reported adult steady-state urine concentrations in those taking TAF and TDF, respectively.In this first pharmacokinetic study of TAF monotherapy in breastfeeding women with CHB, concentrations of TAF and TFV were low in breast milk with negligible infant exposure, supporting the use of TAF to prevent MTCT." @default.
• W4281287750 created "2022-05-24" @default.
• W4281287750 creator A5004264193 @default.
• W4281287750 creator A5021388560 @default.
• W4281287750 creator A5034242048 @default.
• W4281287750 creator A5038434560 @default.
• W4281287750 creator A5043848822 @default.
• W4281287750 creator A5060913459 @default.
• W4281287750 creator A5062263962 @default.
• W4281287750 creator A5079247509 @default.
• W4281287750 creator A5081182002 @default.
• W4281287750 creator A5085988435 @default.
• W4281287750 creator A5088842832 @default.
• W4281287750 date "2022-05-22" @default.
• W4281287750 modified "2023-09-30" @default.
• W4281287750 title "Plasma and breast milk pharmacokinetics of tenofovir alafenamide in mothers with chronic hepatitis B infection" @default.
• W4281287750 cites W1599401828 @default.
• W4281287750 cites W1822512847 @default.
• W4281287750 cites W2013582116 @default.
• W4281287750 cites W2021130749 @default.
• W4281287750 cites W2021553032 @default.
• W4281287750 cites W2051116409 @default.
• W4281287750 cites W2076571011 @default.
• W4281287750 cites W2080544294 @default.
• W4281287750 cites W2090261939 @default.
• W4281287750 cites W2098793704 @default.
• W4281287750 cites W2100045467 @default.
• W4281287750 cites W2121858968 @default.
• W4281287750 cites W2295731785 @default.
• W4281287750 cites W2339438533 @default.
• W4281287750 cites W2344135905 @default.
• W4281287750 cites W2442031947 @default.
• W4281287750 cites W2481556475 @default.
• W4281287750 cites W2527492873 @default.
• W4281287750 cites W2553959110 @default.
• W4281287750 cites W2599563006 @default.
• W4281287750 cites W2605785536 @default.
• W4281287750 cites W2611591031 @default.
• W4281287750 cites W2614636769 @default.
• W4281287750 cites W2782856081 @default.
• W4281287750 cites W2790190820 @default.
• W4281287750 cites W2791839818 @default.
• W4281287750 cites W2886008167 @default.
• W4281287750 cites W2899299145 @default.
• W4281287750 cites W2904182474 @default.
• W4281287750 cites W2963178281 @default.
• W4281287750 cites W2966183270 @default.
• W4281287750 cites W2978375690 @default.
• W4281287750 cites W2997441710 @default.
• W4281287750 cites W2998563068 @default.
• W4281287750 cites W3049411869 @default.
• W4281287750 cites W3080569069 @default.
• W4281287750 cites W3081954126 @default.
• W4281287750 cites W3092167990 @default.
• W4281287750 cites W3135596038 @default.
• W4281287750 cites W3146588168 @default.
• W4281287750 cites W3153805097 @default.
• W4281287750 cites W3184719925 @default.
• W4281287750 cites W4225856862 @default.
• W4281287750 cites W4327847694 @default.
• W4281287750 doi "https://doi.org/10.1111/apt.17040" @default.
• W4281287750 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35599363" @default.
• W4281287750 hasPublicationYear "2022" @default.
• W4281287750 type Work @default.
• W4281287750 citedByCount "5" @default.
• W4281287750 countsByYear W42812877502022 @default.
• W4281287750 countsByYear W42812877502023 @default.
• W4281287750 crossrefType "journal-article" @default.
• W4281287750 hasAuthorship W4281287750A5004264193 @default.
• W4281287750 hasAuthorship W4281287750A5021388560 @default.
• W4281287750 hasAuthorship W4281287750A5034242048 @default.
• W4281287750 hasAuthorship W4281287750A5038434560 @default.
• W4281287750 hasAuthorship W4281287750A5043848822 @default.
• W4281287750 hasAuthorship W4281287750A5060913459 @default.
• W4281287750 hasAuthorship W4281287750A5062263962 @default.
• W4281287750 hasAuthorship W4281287750A5079247509 @default.
• W4281287750 hasAuthorship W4281287750A5081182002 @default.
• W4281287750 hasAuthorship W4281287750A5085988435 @default.
• W4281287750 hasAuthorship W4281287750A5088842832 @default.
• W4281287750 hasBestOaLocation W42812877501 @default.
• W4281287750 hasConcept C112705442 @default.
• W4281287750 hasConcept C126322002 @default.
• W4281287750 hasConcept C131872663 @default.
• W4281287750 hasConcept C142462285 @default.
• W4281287750 hasConcept C185592680 @default.
• W4281287750 hasConcept C187212893 @default.
• W4281287750 hasConcept C203014093 @default.
• W4281287750 hasConcept C22979827 @default.
• W4281287750 hasConcept C2775871700 @default.
• W4281287750 hasConcept C2776283161 @default.
• W4281287750 hasConcept C2780026642 @default.
• W4281287750 hasConcept C2911190787 @default.
• W4281287750 hasConcept C2993143319 @default.
• W4281287750 hasConcept C3013748606 @default.
• W4281287750 hasConcept C3020294031 @default.
• W4281287750 hasConcept C42407357 @default.
• W4281287750 hasConcept C55493867 @default.
• W4281287750 hasConcept C71924100 @default.

• next