FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4281292978> ?p ?o ?g. }

• W4281292978 endingPage "236" @default.
• W4281292978 startingPage "230" @default.
• W4281292978 abstract "Cyclophosphamide is an anticancer drug that acts as an alkylating agent after metabolism in the liver. Despite its many clinical applications in cancer treatment, this drug has toxic effects on the body's organs, especially the genitals. One of the most critical side effects is a change in the function of the female reproductive system, which can lead to infertility. This study aimed to investigate the antioxidant effects of coenzyme Q10 on cyclophosphamide-induced toxicity in vitro fertilized embryos in mice. In this experimental study, 24 female mice weighing 25 g 4 groups of 6 were divided and treated for 21 days. The first group (control group), solvent (cyclophosphamide) including DMSO and PBS (0.1 ml intraperitoneally), the second group (sham group), cyclophosphamide at a dose of 10 mg/kg was injected as a single dose, and the third group (experimental group), along with single-dose cyclophosphamide, coenzyme Q10 at a dose of 200 mg/kg/day was injected intraperitoneally and the fourth group (positive control group), only coenzyme Q10 at a dose of 200 mg/kg/day was injected intraperitoneally. At the end of the treatment period, ovulation stimulation was performed using PMSG and HCG hormones. Six adult male mice were used to prepare normal sperm. The animals were facilitated after anesthesia. After extraction of regular eggs and sperm and fertilization in HTF + 4 mg BSA medium, the fertilized eggs were incubated for 120 hours, and the embryonic developmental stages were examined during this period. Were analyzed by ANOVA and comparison of ratios. Cyclophosphamide significantly reduced oocyte quality, fertilization rate, pre-implantation embryonic development, and embryo quality. Coenzyme Q10 (Co Q10) significantly reduced the adverse effects of cyclophosphamide. The present study showed that crocin could protect the fertility of the female sex against damage caused by cyclophosphamide. " @default.
• W4281292978 created "2022-05-24" @default.
• W4281292978 creator A5032248035 @default.
• W4281292978 creator A5057755011 @default.
• W4281292978 creator A5071806407 @default.
• W4281292978 date "2022-05-01" @default.
• W4281292978 modified "2023-10-01" @default.
• W4281292978 title "Evaluation of the protective effect of coenzyme Q10 on the growth process of embryos from in vitro fertilization in laboratory mice treated with cyclophosphamide" @default.
• W4281292978 cites W123868271 @default.
• W4281292978 cites W1969319285 @default.
• W4281292978 cites W1971710835 @default.
• W4281292978 cites W1976821563 @default.
• W4281292978 cites W1986269821 @default.
• W4281292978 cites W1996566701 @default.
• W4281292978 cites W2004600992 @default.
• W4281292978 cites W2016382643 @default.
• W4281292978 cites W2021071018 @default.
• W4281292978 cites W2031052102 @default.
• W4281292978 cites W2035053588 @default.
• W4281292978 cites W2053010552 @default.
• W4281292978 cites W2055493372 @default.
• W4281292978 cites W2057256114 @default.
• W4281292978 cites W2061907984 @default.
• W4281292978 cites W2073217508 @default.
• W4281292978 cites W2076977009 @default.
• W4281292978 cites W2094137902 @default.
• W4281292978 cites W2118412942 @default.
• W4281292978 cites W2149160427 @default.
• W4281292978 cites W2166874810 @default.
• W4281292978 cites W2167160116 @default.
• W4281292978 cites W2169706900 @default.
• W4281292978 cites W2335332412 @default.
• W4281292978 cites W2603573106 @default.
• W4281292978 doi "https://doi.org/10.55453/rjmm.2022.125.2.9" @default.
• W4281292978 hasPublicationYear "2022" @default.
• W4281292978 type Work @default.
• W4281292978 citedByCount "0" @default.
• W4281292978 crossrefType "journal-article" @default.
• W4281292978 hasAuthorship W4281292978A5032248035 @default.
• W4281292978 hasAuthorship W4281292978A5057755011 @default.
• W4281292978 hasAuthorship W4281292978A5071806407 @default.
• W4281292978 hasConcept C105702510 @default.
• W4281292978 hasConcept C126322002 @default.
• W4281292978 hasConcept C134018914 @default.
• W4281292978 hasConcept C16685009 @default.
• W4281292978 hasConcept C185592680 @default.
• W4281292978 hasConcept C196843134 @default.
• W4281292978 hasConcept C2776694085 @default.
• W4281292978 hasConcept C2776755627 @default.
• W4281292978 hasConcept C2777688143 @default.
• W4281292978 hasConcept C2779234561 @default.
• W4281292978 hasConcept C2779384338 @default.
• W4281292978 hasConcept C2781087480 @default.
• W4281292978 hasConcept C29730261 @default.
• W4281292978 hasConcept C54355233 @default.
• W4281292978 hasConcept C71924100 @default.
• W4281292978 hasConcept C86803240 @default.
• W4281292978 hasConcept C88972607 @default.
• W4281292978 hasConcept C95444343 @default.
• W4281292978 hasConcept C98274493 @default.
• W4281292978 hasConceptScore W4281292978C105702510 @default.
• W4281292978 hasConceptScore W4281292978C126322002 @default.
• W4281292978 hasConceptScore W4281292978C134018914 @default.
• W4281292978 hasConceptScore W4281292978C16685009 @default.
• W4281292978 hasConceptScore W4281292978C185592680 @default.
• W4281292978 hasConceptScore W4281292978C196843134 @default.
• W4281292978 hasConceptScore W4281292978C2776694085 @default.
• W4281292978 hasConceptScore W4281292978C2776755627 @default.
• W4281292978 hasConceptScore W4281292978C2777688143 @default.
• W4281292978 hasConceptScore W4281292978C2779234561 @default.
• W4281292978 hasConceptScore W4281292978C2779384338 @default.
• W4281292978 hasConceptScore W4281292978C2781087480 @default.
• W4281292978 hasConceptScore W4281292978C29730261 @default.
• W4281292978 hasConceptScore W4281292978C54355233 @default.
• W4281292978 hasConceptScore W4281292978C71924100 @default.
• W4281292978 hasConceptScore W4281292978C86803240 @default.
• W4281292978 hasConceptScore W4281292978C88972607 @default.
• W4281292978 hasConceptScore W4281292978C95444343 @default.
• W4281292978 hasConceptScore W4281292978C98274493 @default.
• W4281292978 hasIssue "2" @default.
• W4281292978 hasLocation W42812929781 @default.
• W4281292978 hasOpenAccess W4281292978 @default.
• W4281292978 hasPrimaryLocation W42812929781 @default.
• W4281292978 hasRelatedWork W1212356979 @default.
• W4281292978 hasRelatedWork W1999149485 @default.
• W4281292978 hasRelatedWork W2027483869 @default.
• W4281292978 hasRelatedWork W2058612019 @default.
• W4281292978 hasRelatedWork W2069824182 @default.
• W4281292978 hasRelatedWork W2124023394 @default.
• W4281292978 hasRelatedWork W2352671946 @default.
• W4281292978 hasRelatedWork W2367258775 @default.
• W4281292978 hasRelatedWork W2379294160 @default.
• W4281292978 hasRelatedWork W2748952813 @default.
• W4281292978 hasVolume "125" @default.
• W4281292978 isParatext "false" @default.
• W4281292978 isRetracted "false" @default.
• W4281292978 workType "article" @default.