Matches in SemOpenAlex for { <https://semopenalex.org/work/W4281382365> ?p ?o ?g. }
- W4281382365 abstract "Developing quorum-sensing (QS) based anti-infection drugs is one of the most powerful strategies to combat multidrug-resistant bacteria. Paeonol has been proven to attenuate the QS-controlled virulence factors of P. aeruginosa by down-regulating the transcription of QS signal molecules. This research aimed to assess the anti-virulence activity and mechanism of paeonol against P. aeruginosa infection in vitro and in vivo. In this study, paeonol was found to reduce the adhesion and invasion of P.aeruginosa to macrophages and resist the cytotoxicity induced by P.aeruginosa. Paeonol reduced the expression of virulence factors of P.aeruginosa by inhibiting QS, thereby reducing the LDH release and damage of P.aeruginosa-infected macrophages. Paeonol can inhibit bacterial virulence and enhance the ability of macrophages to clear P.aeruginosa. In addition, paeonol exerts anti-inflammatory activity by reducing the expression of inflammatory cytokines and increasing the production of anti-inflammatory cytokines. Paeonol treatment significantly inhibited the activation of TLR4/MyD88/NF-κB signaling pathway and decreased the inflammation response of P. aeruginosa-infected macrophages. Paeonol also significantly reduced the ability of P.aeruginosa to infect mice and reduced the inflammatory response. These data suggest that paeonol can inhibit the virulence of P.aeruginosa and decrease the inflammation response in P.aeruginosa-infected macrophages and mice, which can decrease the damage induced by P.aeruginosa infection and enhance the ability of macrophages to clear bacteria. This study supports the further development of new potential anti-infective drugs based on inhibition of QS and virulence factors." @default.
- W4281382365 created "2022-05-25" @default.
- W4281382365 creator A5004326765 @default.
- W4281382365 creator A5009876003 @default.
- W4281382365 creator A5024795666 @default.
- W4281382365 creator A5036456536 @default.
- W4281382365 creator A5037736384 @default.
- W4281382365 creator A5050008101 @default.
- W4281382365 creator A5062307969 @default.
- W4281382365 creator A5064813580 @default.
- W4281382365 creator A5079878898 @default.
- W4281382365 creator A5089684709 @default.
- W4281382365 date "2022-05-24" @default.
- W4281382365 modified "2023-10-16" @default.
- W4281382365 title "Paeonol Interferes With Quorum-Sensing in Pseudomonas aeruginosa and Modulates Inflammatory Responses In Vitro and In Vivo" @default.
- W4281382365 cites W1492166146 @default.
- W4281382365 cites W1555657499 @default.
- W4281382365 cites W1751253656 @default.
- W4281382365 cites W1797422316 @default.
- W4281382365 cites W1833951784 @default.
- W4281382365 cites W1907075739 @default.
- W4281382365 cites W1969393800 @default.
- W4281382365 cites W1975587832 @default.
- W4281382365 cites W1977592340 @default.
- W4281382365 cites W1981751490 @default.
- W4281382365 cites W1983964720 @default.
- W4281382365 cites W1990893520 @default.
- W4281382365 cites W1991185106 @default.
- W4281382365 cites W1996120942 @default.
- W4281382365 cites W2002773042 @default.
- W4281382365 cites W2014628941 @default.
- W4281382365 cites W2018607958 @default.
- W4281382365 cites W2022914875 @default.
- W4281382365 cites W2036504193 @default.
- W4281382365 cites W2036767516 @default.
- W4281382365 cites W2037432461 @default.
- W4281382365 cites W2038719177 @default.
- W4281382365 cites W2044757050 @default.
- W4281382365 cites W2046134396 @default.
- W4281382365 cites W2070855360 @default.
- W4281382365 cites W2077730689 @default.
- W4281382365 cites W2079698171 @default.
- W4281382365 cites W2085454008 @default.
- W4281382365 cites W2086067382 @default.
- W4281382365 cites W2089938014 @default.
- W4281382365 cites W2096403945 @default.
- W4281382365 cites W2098085255 @default.
- W4281382365 cites W2100669918 @default.
- W4281382365 cites W2108638835 @default.
- W4281382365 cites W2109038233 @default.
- W4281382365 cites W2109491705 @default.
- W4281382365 cites W2114217815 @default.
- W4281382365 cites W2114405820 @default.
- W4281382365 cites W2127299218 @default.
- W4281382365 cites W2140625643 @default.
- W4281382365 cites W2150188452 @default.
- W4281382365 cites W2150907717 @default.
- W4281382365 cites W2167349697 @default.
- W4281382365 cites W2272680979 @default.
- W4281382365 cites W2588657365 @default.
- W4281382365 cites W2611183201 @default.
- W4281382365 cites W2616747074 @default.
- W4281382365 cites W2941184640 @default.
- W4281382365 cites W2967960079 @default.
- W4281382365 cites W3035830570 @default.
- W4281382365 cites W3044958952 @default.
- W4281382365 cites W3119825566 @default.
- W4281382365 cites W3127394750 @default.
- W4281382365 cites W3129186960 @default.
- W4281382365 cites W3158884891 @default.
- W4281382365 cites W3187644879 @default.
- W4281382365 cites W4239787408 @default.
- W4281382365 cites W4246645615 @default.
- W4281382365 doi "https://doi.org/10.3389/fimmu.2022.896874" @default.
- W4281382365 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35686124" @default.
- W4281382365 hasPublicationYear "2022" @default.
- W4281382365 type Work @default.
- W4281382365 citedByCount "7" @default.
- W4281382365 countsByYear W42813823652023 @default.
- W4281382365 crossrefType "journal-article" @default.
- W4281382365 hasAuthorship W4281382365A5004326765 @default.
- W4281382365 hasAuthorship W4281382365A5009876003 @default.
- W4281382365 hasAuthorship W4281382365A5024795666 @default.
- W4281382365 hasAuthorship W4281382365A5036456536 @default.
- W4281382365 hasAuthorship W4281382365A5037736384 @default.
- W4281382365 hasAuthorship W4281382365A5050008101 @default.
- W4281382365 hasAuthorship W4281382365A5062307969 @default.
- W4281382365 hasAuthorship W4281382365A5064813580 @default.
- W4281382365 hasAuthorship W4281382365A5079878898 @default.
- W4281382365 hasAuthorship W4281382365A5089684709 @default.
- W4281382365 hasBestOaLocation W42813823651 @default.
- W4281382365 hasConcept C104317684 @default.
- W4281382365 hasConcept C118687296 @default.
- W4281382365 hasConcept C142724271 @default.
- W4281382365 hasConcept C150903083 @default.
- W4281382365 hasConcept C185592680 @default.
- W4281382365 hasConcept C202751555 @default.
- W4281382365 hasConcept C204787440 @default.
- W4281382365 hasConcept C207001950 @default.
- W4281382365 hasConcept C2777637488 @default.