Matches in SemOpenAlex for { <https://semopenalex.org/work/W4281383094> ?p ?o ?g. }
- W4281383094 endingPage "2573" @default.
- W4281383094 startingPage "2573" @default.
- W4281383094 abstract "Obesity, metabolic changes, and intestinal microbiota disruption significantly affect tumorigenesis and metastasis in colorectal cancer (CRC). However, the relationships among these factors remain poorly understood. In this study, we found that a high-fat diet (HFD) promoted gut barrier dysfunction and inflammation in the colorectum and liver. We further investigated gut microbiota changes through 16S rRNA sequencing of faecal samples from HFD-fed rats and CRC hepatic metastasis patients and found an abundance of Desulfovibrio (DSV). DSV could also induce barrier dysfunction in the colorectum and inflammation in the colorectum and liver, suggesting that it contributes to the formation of a microenvironment conducive to CRC tumorigenesis and metastasis. These findings highlight that HFD-induced microbiota dysbiosis, especially DSV abundance, could promote CRC initiation and metastasis." @default.
- W4281383094 created "2022-05-25" @default.
- W4281383094 creator A5005901587 @default.
- W4281383094 creator A5009223452 @default.
- W4281383094 creator A5014468737 @default.
- W4281383094 creator A5021005601 @default.
- W4281383094 creator A5041841022 @default.
- W4281383094 creator A5050048280 @default.
- W4281383094 creator A5053671532 @default.
- W4281383094 creator A5054399423 @default.
- W4281383094 creator A5072124184 @default.
- W4281383094 creator A5076385892 @default.
- W4281383094 date "2022-05-24" @default.
- W4281383094 modified "2023-10-14" @default.
- W4281383094 title "High-Fat Diet Enhances the Liver Metastasis Potential of Colorectal Cancer through Microbiota Dysbiosis" @default.
- W4281383094 cites W1520425169 @default.
- W4281383094 cites W1946762479 @default.
- W4281383094 cites W1964162393 @default.
- W4281383094 cites W2011132772 @default.
- W4281383094 cites W2033000270 @default.
- W4281383094 cites W2048678284 @default.
- W4281383094 cites W2074425838 @default.
- W4281383094 cites W2118224153 @default.
- W4281383094 cites W2143269314 @default.
- W4281383094 cites W2146488133 @default.
- W4281383094 cites W2146530991 @default.
- W4281383094 cites W2151127655 @default.
- W4281383094 cites W2151798187 @default.
- W4281383094 cites W2169744880 @default.
- W4281383094 cites W2254366662 @default.
- W4281383094 cites W2412123090 @default.
- W4281383094 cites W2514873437 @default.
- W4281383094 cites W2551647589 @default.
- W4281383094 cites W2552631557 @default.
- W4281383094 cites W2585923386 @default.
- W4281383094 cites W2596133050 @default.
- W4281383094 cites W2625068954 @default.
- W4281383094 cites W2626439516 @default.
- W4281383094 cites W2749700969 @default.
- W4281383094 cites W2756413447 @default.
- W4281383094 cites W2763151664 @default.
- W4281383094 cites W2769660358 @default.
- W4281383094 cites W2798050410 @default.
- W4281383094 cites W2889646458 @default.
- W4281383094 cites W2898404101 @default.
- W4281383094 cites W2899047514 @default.
- W4281383094 cites W2900847413 @default.
- W4281383094 cites W2906748726 @default.
- W4281383094 cites W2949004447 @default.
- W4281383094 cites W2950945543 @default.
- W4281383094 cites W2956129408 @default.
- W4281383094 cites W2964373997 @default.
- W4281383094 cites W2970913246 @default.
- W4281383094 cites W2973417369 @default.
- W4281383094 cites W2979189134 @default.
- W4281383094 cites W2980944208 @default.
- W4281383094 cites W2981557809 @default.
- W4281383094 cites W3009566356 @default.
- W4281383094 cites W3013845627 @default.
- W4281383094 cites W3014111827 @default.
- W4281383094 cites W3015274768 @default.
- W4281383094 cites W3017649690 @default.
- W4281383094 cites W3022864888 @default.
- W4281383094 cites W3043489919 @default.
- W4281383094 cites W3045114299 @default.
- W4281383094 cites W3082936221 @default.
- W4281383094 cites W3148950123 @default.
- W4281383094 cites W757182521 @default.
- W4281383094 doi "https://doi.org/10.3390/cancers14112573" @default.
- W4281383094 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35681554" @default.
- W4281383094 hasPublicationYear "2022" @default.
- W4281383094 type Work @default.
- W4281383094 citedByCount "9" @default.
- W4281383094 countsByYear W42813830942022 @default.
- W4281383094 countsByYear W42813830942023 @default.
- W4281383094 crossrefType "journal-article" @default.
- W4281383094 hasAuthorship W4281383094A5005901587 @default.
- W4281383094 hasAuthorship W4281383094A5009223452 @default.
- W4281383094 hasAuthorship W4281383094A5014468737 @default.
- W4281383094 hasAuthorship W4281383094A5021005601 @default.
- W4281383094 hasAuthorship W4281383094A5041841022 @default.
- W4281383094 hasAuthorship W4281383094A5050048280 @default.
- W4281383094 hasAuthorship W4281383094A5053671532 @default.
- W4281383094 hasAuthorship W4281383094A5054399423 @default.
- W4281383094 hasAuthorship W4281383094A5072124184 @default.
- W4281383094 hasAuthorship W4281383094A5076385892 @default.
- W4281383094 hasBestOaLocation W42813830941 @default.
- W4281383094 hasConcept C121608353 @default.
- W4281383094 hasConcept C126322002 @default.
- W4281383094 hasConcept C203014093 @default.
- W4281383094 hasConcept C2776107976 @default.
- W4281383094 hasConcept C2776914184 @default.
- W4281383094 hasConcept C2777165150 @default.
- W4281383094 hasConcept C2779013556 @default.
- W4281383094 hasConcept C502942594 @default.
- W4281383094 hasConcept C526805850 @default.
- W4281383094 hasConcept C539455810 @default.
- W4281383094 hasConcept C555283112 @default.