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• W4281383146 abstract "G2019S (GS) is the most prevalent mutation in the leucine rich repeat protein kinase 2 gene (LRRK2), a genetic predisposition that is common for Parkinson’s disease, as well as for some forms of cancer, and is a shared risk allele for Crohn’s disease. GS-LRRK2 has a hyperactive kinase, and although numerous drug discovery programs have targeted LRRK2 kinase, few have reached clinical development. We report the discovery and preliminary development of an entirely novel structural class of potent and selective GS-LRRK2 kinase inhibitors: biaryl-1H-pyrazoles." @default.
• W4281383146 created "2022-05-25" @default.
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• W4281383146 date "2022-05-23" @default.
• W4281383146 modified "2023-09-26" @default.
• W4281383146 title "Discovery of 1<i>H-</i>Pyrazole Biaryl Sulfonamides as Novel G2019S-LRRK2 Kinase Inhibitors" @default.
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• W4281383146 doi "https://doi.org/10.1021/acsmedchemlett.2c00116" @default.
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