FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4281384164> ?p ?o ?g. }

• W4281384164 endingPage "111244" @default.
• W4281384164 startingPage "111244" @default.
• W4281384164 abstract "Vertebrates need oxygen to survive. The central nervous system has an especially high energy demand, so brain and retinal neurons quickly die in anoxia. But fish of the genus Carassius are exceptionally anoxia-tolerant: the crucian carp (C. carassius) can survive months without oxygen in ice-covered ponds, and the common goldfish (C. auratus) can withstand hours of anoxia at room temperature. These fish previously offered insights into anoxia tolerance in the brain, heart, and liver. Here, we advance Carassius spp. as models to study anoxia tolerance in the retina. Electroretinogram and evoked potential recordings show that crucian carp reversibly downregulate their visual systems in anoxia, probably to save ATP. Notably, Carassius suppress their visual systems nearly twice as much as anoxia-tolerant turtles, Trachemys and Chrysemys spp., which are often promoted as the champions of anoxia tolerance. We summarize what is known about anoxia tolerance in the goldfish and crucian carp retinas, including cellular pathways which may protect retinal neurons from excitotoxic cell death. We compare the Carassius retina with two relevant models: natural anoxia tolerance in the turtle brain, and ischemic preconditioning in the rat retina. All three models include mitochondria as oxygen sensors: mitochondria depolarize due to mitochondrial ATP-dependent K+ channels, possibly to trigger neuroprotective second messenger cascades. The Carassius retina is an accessible and inexpensive model, with over 70 fruitful years of history in vision research. As a model for anoxia tolerance, it may provide new insights into diseases of the eye (like diabetes, macular degeneration, and eye stroke)." @default.
• W4281384164 created "2022-05-25" @default.
• W4281384164 creator A5033257025 @default.
• W4281384164 creator A5071629371 @default.
• W4281384164 date "2022-08-01" @default.
• W4281384164 modified "2023-09-27" @default.
• W4281384164 title "Goldfish and crucian carp are natural models of anoxia tolerance in the retina" @default.
• W4281384164 cites W134318258 @default.
• W4281384164 cites W1895940050 @default.
• W4281384164 cites W1935545948 @default.
• W4281384164 cites W1937717811 @default.
• W4281384164 cites W1974731702 @default.
• W4281384164 cites W1978423700 @default.
• W4281384164 cites W1984116072 @default.
• W4281384164 cites W1984990667 @default.
• W4281384164 cites W2000344192 @default.
• W4281384164 cites W2001024070 @default.
• W4281384164 cites W2005093873 @default.
• W4281384164 cites W2006584544 @default.
• W4281384164 cites W2009771084 @default.
• W4281384164 cites W2016402579 @default.
• W4281384164 cites W2024572865 @default.
• W4281384164 cites W2032158938 @default.
• W4281384164 cites W2038081600 @default.
• W4281384164 cites W2052109950 @default.
• W4281384164 cites W2055533069 @default.
• W4281384164 cites W2077525659 @default.
• W4281384164 cites W2089582877 @default.
• W4281384164 cites W2091208643 @default.
• W4281384164 cites W2097293665 @default.
• W4281384164 cites W2106197267 @default.
• W4281384164 cites W2120992133 @default.
• W4281384164 cites W2121288152 @default.
• W4281384164 cites W2127650012 @default.
• W4281384164 cites W2135608921 @default.
• W4281384164 cites W2139921047 @default.
• W4281384164 cites W2144918294 @default.
• W4281384164 cites W2162672064 @default.
• W4281384164 cites W2163081858 @default.
• W4281384164 cites W2163605062 @default.
• W4281384164 cites W2548609036 @default.
• W4281384164 cites W2736020006 @default.
• W4281384164 cites W2740094142 @default.
• W4281384164 cites W2744240621 @default.
• W4281384164 cites W292775738 @default.
• W4281384164 cites W3084542848 @default.
• W4281384164 cites W3194698932 @default.
• W4281384164 cites W4220791200 @default.
• W4281384164 doi "https://doi.org/10.1016/j.cbpa.2022.111244" @default.
• W4281384164 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35618216" @default.
• W4281384164 hasPublicationYear "2022" @default.
• W4281384164 type Work @default.
• W4281384164 citedByCount "2" @default.
• W4281384164 countsByYear W42813841642023 @default.
• W4281384164 crossrefType "journal-article" @default.
• W4281384164 hasAuthorship W4281384164A5033257025 @default.
• W4281384164 hasAuthorship W4281384164A5071629371 @default.
• W4281384164 hasConcept C105702510 @default.
• W4281384164 hasConcept C169760540 @default.
• W4281384164 hasConcept C25498285 @default.
• W4281384164 hasConcept C2776461903 @default.
• W4281384164 hasConcept C2777093970 @default.
• W4281384164 hasConcept C2777142705 @default.
• W4281384164 hasConcept C2780827179 @default.
• W4281384164 hasConcept C2909208804 @default.
• W4281384164 hasConcept C2994357808 @default.
• W4281384164 hasConcept C505870484 @default.
• W4281384164 hasConcept C59822182 @default.
• W4281384164 hasConcept C86803240 @default.
• W4281384164 hasConcept C95444343 @default.
• W4281384164 hasConceptScore W4281384164C105702510 @default.
• W4281384164 hasConceptScore W4281384164C169760540 @default.
• W4281384164 hasConceptScore W4281384164C25498285 @default.
• W4281384164 hasConceptScore W4281384164C2776461903 @default.
• W4281384164 hasConceptScore W4281384164C2777093970 @default.
• W4281384164 hasConceptScore W4281384164C2777142705 @default.
• W4281384164 hasConceptScore W4281384164C2780827179 @default.
• W4281384164 hasConceptScore W4281384164C2909208804 @default.
• W4281384164 hasConceptScore W4281384164C2994357808 @default.
• W4281384164 hasConceptScore W4281384164C505870484 @default.
• W4281384164 hasConceptScore W4281384164C59822182 @default.
• W4281384164 hasConceptScore W4281384164C86803240 @default.
• W4281384164 hasConceptScore W4281384164C95444343 @default.
• W4281384164 hasFunder F4320334593 @default.
• W4281384164 hasLocation W42813841641 @default.
• W4281384164 hasLocation W42813841642 @default.
• W4281384164 hasOpenAccess W4281384164 @default.
• W4281384164 hasPrimaryLocation W42813841641 @default.
• W4281384164 hasRelatedWork W1977206102 @default.
• W4281384164 hasRelatedWork W2058449782 @default.
• W4281384164 hasRelatedWork W2069890030 @default.
• W4281384164 hasRelatedWork W2082119070 @default.
• W4281384164 hasRelatedWork W2126627637 @default.
• W4281384164 hasRelatedWork W2372499373 @default.
• W4281384164 hasRelatedWork W2398122891 @default.
• W4281384164 hasRelatedWork W2507974839 @default.
• W4281384164 hasRelatedWork W2790218992 @default.
• W4281384164 hasRelatedWork W4283209163 @default.

• next