FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4281384911> ?p ?o ?g. }

• W4281384911 endingPage "4872" @default.
• W4281384911 startingPage "4859" @default.
• W4281384911 abstract "We established and characterized a bank of 138 CMVpp65 peptide-specific T-cell (CMVpp65CTLs) lines from healthy marrow transplant donors who consented to their use for treatment of individuals other than their transplant recipient. CMVpp65CTL lines included 131 containing predominantly CD8+ T cells and 7 CD4+ T cells. CD8+ CMVpp65CTLs were specific for 1 to 3 epitopes each presented by one of only 34 of the 148 class I alleles in the bank. Similarly, the 7 predominantly CD4+ CMVpp65CTL lines were each specific for epitopes presented by 14 of 40 HLA DR alleles in the bank. Although the number of HLA alleles presenting CMV epitopes is low, their prevalence is high, permitting selection of CMVpp65CTLs restricted by an HLA allele shared by transplant recipient and hematopoietic cell transplant donor for >90% of an ethnogeographically diverse population of hematopoietic cell transplant recipients. Within individuals, responses to CMVpp65 peptides presented by different HLA alleles are hierarchical. Furthermore, within groups, epitopes presented by HLA B*07:02 and HLA A*02:01 consistently elicit immunodominant CMVpp65CTLs, irrespective of other HLA alleles inherited. All dominant CMVpp65CTLs exhibited HLA-restricted cytotoxicity against epitope loaded targets and usually cleared CMV infections. However, immunodominant CMVpp65CTLs responding to epitopes presented by certain HLA B*35 alleles were ineffective in lysing CMV-infected cells in vitro or controlling CMV infections post adoptive therapy. Analysis of the hierarchy of T-cell responses to CMVpp65, the HLA alleles presenting immunodominant CMVpp65 epitopes, and the responses they induce may lead to detailed algorithms for optimal choice of third-party CMVpp65CTLs for effective adoptive therapy." @default.
• W4281384911 created "2022-05-25" @default.
• W4281384911 creator A5031035765 @default.
• W4281384911 creator A5031624735 @default.
• W4281384911 creator A5045252431 @default.
• W4281384911 creator A5052956899 @default.
• W4281384911 creator A5056539557 @default.
• W4281384911 creator A5058476408 @default.
• W4281384911 creator A5061721767 @default.
• W4281384911 creator A5077471908 @default.
• W4281384911 creator A5081203794 @default.
• W4281384911 creator A5088746373 @default.
• W4281384911 date "2022-08-22" @default.
• W4281384911 modified "2023-09-30" @default.
• W4281384911 title "Dominant epitopes presented by prevalent HLA alleles permit wide use of banked CMVpp65 T cells in adoptive therapy" @default.
• W4281384911 cites W1554018264 @default.
• W4281384911 cites W1564109452 @default.
• W4281384911 cites W1568041502 @default.
• W4281384911 cites W1674854702 @default.
• W4281384911 cites W1828864370 @default.
• W4281384911 cites W1895052014 @default.
• W4281384911 cites W1965808102 @default.
• W4281384911 cites W1971842136 @default.
• W4281384911 cites W1973683879 @default.
• W4281384911 cites W1976058260 @default.
• W4281384911 cites W1986797533 @default.
• W4281384911 cites W1999002546 @default.
• W4281384911 cites W2001322181 @default.
• W4281384911 cites W2008791835 @default.
• W4281384911 cites W2017769703 @default.
• W4281384911 cites W2028267776 @default.
• W4281384911 cites W2032094289 @default.
• W4281384911 cites W2039848934 @default.
• W4281384911 cites W2045209342 @default.
• W4281384911 cites W2045407060 @default.
• W4281384911 cites W2045551237 @default.
• W4281384911 cites W2063128000 @default.
• W4281384911 cites W2063473780 @default.
• W4281384911 cites W2063511434 @default.
• W4281384911 cites W2063945161 @default.
• W4281384911 cites W2069720281 @default.
• W4281384911 cites W2070343121 @default.
• W4281384911 cites W2070725742 @default.
• W4281384911 cites W2072132286 @default.
• W4281384911 cites W2075977123 @default.
• W4281384911 cites W2085013724 @default.
• W4281384911 cites W2086024031 @default.
• W4281384911 cites W2090046872 @default.
• W4281384911 cites W2098816998 @default.
• W4281384911 cites W2102510758 @default.
• W4281384911 cites W2110659047 @default.
• W4281384911 cites W2112067138 @default.
• W4281384911 cites W2118937969 @default.
• W4281384911 cites W2119627739 @default.
• W4281384911 cites W2122615595 @default.
• W4281384911 cites W2134182833 @default.
• W4281384911 cites W2138567003 @default.
• W4281384911 cites W2144332894 @default.
• W4281384911 cites W2154966612 @default.
• W4281384911 cites W2156248061 @default.
• W4281384911 cites W2159533656 @default.
• W4281384911 cites W2161944139 @default.
• W4281384911 cites W2166577975 @default.
• W4281384911 cites W2168688111 @default.
• W4281384911 cites W2285684471 @default.
• W4281384911 cites W2315326052 @default.
• W4281384911 cites W2338358489 @default.
• W4281384911 cites W2395266396 @default.
• W4281384911 cites W2555695588 @default.
• W4281384911 cites W2591348853 @default.
• W4281384911 cites W2889251535 @default.
• W4281384911 cites W2961599785 @default.
• W4281384911 cites W2971794607 @default.
• W4281384911 cites W2984115981 @default.
• W4281384911 cites W2986046464 @default.
• W4281384911 cites W3134236823 @default.
• W4281384911 cites W40694895 @default.
• W4281384911 cites W615767715 @default.
• W4281384911 doi "https://doi.org/10.1182/bloodadvances.2022007005" @default.
• W4281384911 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35605246" @default.
• W4281384911 hasPublicationYear "2022" @default.
• W4281384911 type Work @default.
• W4281384911 citedByCount "5" @default.
• W4281384911 countsByYear W42813849112022 @default.
• W4281384911 countsByYear W42813849112023 @default.
• W4281384911 crossrefType "journal-article" @default.
• W4281384911 hasAuthorship W4281384911A5031035765 @default.
• W4281384911 hasAuthorship W4281384911A5031624735 @default.
• W4281384911 hasAuthorship W4281384911A5045252431 @default.
• W4281384911 hasAuthorship W4281384911A5052956899 @default.
• W4281384911 hasAuthorship W4281384911A5056539557 @default.
• W4281384911 hasAuthorship W4281384911A5058476408 @default.
• W4281384911 hasAuthorship W4281384911A5061721767 @default.
• W4281384911 hasAuthorship W4281384911A5077471908 @default.
• W4281384911 hasAuthorship W4281384911A5081203794 @default.
• W4281384911 hasAuthorship W4281384911A5088746373 @default.
• W4281384911 hasBestOaLocation W42813849111 @default.
• W4281384911 hasConcept C104317684 @default.

• next