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- W4281387788 abstract "TLR4 is a receptor involved in the inflammatory response of macrophages to lipopolysaccharide (LPS). Its co-receptor CD14 facilitates LPS-induced activation and endocytosis of TLR4. We studied CD14 trafficking which is profoundly different than that of TLR4. We discovered that after endocytosis CD14 can recycle back to the plasma membrane. This process, regulated by sorting nexins SNX1, SNX2 and SNX6, is important for maintaining the surface level of CD14 in resting cells and for subsequent inflammatory response of macrophages to LPS." @default.
- W4281387788 created "2022-05-25" @default.
- W4281387788 date "2022-06-01" @default.
- W4281387788 modified "2023-10-16" @default.
- W4281387788 doi "https://doi.org/10.1111/tra.v23.6" @default.
- W4281387788 hasPublicationYear "2022" @default.
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