Matches in SemOpenAlex for { <https://semopenalex.org/work/W4281388542> ?p ?o ?g. }
- W4281388542 endingPage "112590" @default.
- W4281388542 startingPage "112590" @default.
- W4281388542 abstract "Non-steroidal anti-inflammatory drugs (NSAIDs) are commonly used for the treatment of pain, inflammation and fever. However, most NSAIDs are poorly water soluble, making it difficult to be administered thus high doses are required to reach the intended therapeutic effect, resulting in associated side effects. In this study, ROS-responsive micellar systems based on a block copolymer consisting of methylpropyl thioether (MTPA) and N ’ N -dimethylacrylamide was developed and loaded with ibuprofen (IBU). Using lipopolysaccharide activated RAW 264.7 macrophage like cells, we demonstrated that IBU was released from the copolymer, specifically in the presence of ROS. Interestingly, IBU encapsulated in ROS-responsive nanoparticles exhibited greater anti-inflammatory potency compared to its free form. The work highlights the potential of the ROS-responsive micellar system developed in this work to be used as carrier of NSAIDs for the treatment of relevant inflammatory conditions. • ROS-responsive thioether based diblock copolymer was synthesized. • Ibuprofen was loaded into micelles formed by the amphiphilic copolymer. • Polymeric micelles loaded with ibuprofen demonstrated ROS-triggered release. • Encapsulated ibuprofen showed greater anti-inflammatory potency than its free form." @default.
- W4281388542 created "2022-05-25" @default.
- W4281388542 creator A5021592265 @default.
- W4281388542 creator A5023489689 @default.
- W4281388542 creator A5053551404 @default.
- W4281388542 creator A5060247750 @default.
- W4281388542 date "2022-09-01" @default.
- W4281388542 modified "2023-09-26" @default.
- W4281388542 title "ROS-responsive copolymer micelles for inflammation triggered delivery of ibuprofen" @default.
- W4281388542 cites W1554988383 @default.
- W4281388542 cites W1591138153 @default.
- W4281388542 cites W1860372585 @default.
- W4281388542 cites W1976465735 @default.
- W4281388542 cites W1976599392 @default.
- W4281388542 cites W1977106273 @default.
- W4281388542 cites W1990165855 @default.
- W4281388542 cites W1993954350 @default.
- W4281388542 cites W1994942442 @default.
- W4281388542 cites W2000584621 @default.
- W4281388542 cites W2012682021 @default.
- W4281388542 cites W2013086882 @default.
- W4281388542 cites W2025754951 @default.
- W4281388542 cites W2028742202 @default.
- W4281388542 cites W2042901064 @default.
- W4281388542 cites W2048617716 @default.
- W4281388542 cites W2052144010 @default.
- W4281388542 cites W2055321318 @default.
- W4281388542 cites W2068767719 @default.
- W4281388542 cites W2081839893 @default.
- W4281388542 cites W2088467380 @default.
- W4281388542 cites W2088810644 @default.
- W4281388542 cites W2092710627 @default.
- W4281388542 cites W2102472842 @default.
- W4281388542 cites W2105674927 @default.
- W4281388542 cites W2117289416 @default.
- W4281388542 cites W2132693984 @default.
- W4281388542 cites W2147465625 @default.
- W4281388542 cites W2154240211 @default.
- W4281388542 cites W2213746779 @default.
- W4281388542 cites W2237495275 @default.
- W4281388542 cites W2326142286 @default.
- W4281388542 cites W2331824001 @default.
- W4281388542 cites W2461275589 @default.
- W4281388542 cites W2508999160 @default.
- W4281388542 cites W2568510753 @default.
- W4281388542 cites W2579843332 @default.
- W4281388542 cites W2620635786 @default.
- W4281388542 cites W2775131622 @default.
- W4281388542 cites W2782247843 @default.
- W4281388542 cites W2794323849 @default.
- W4281388542 cites W2910853950 @default.
- W4281388542 cites W2947516626 @default.
- W4281388542 cites W2953790914 @default.
- W4281388542 cites W2963587645 @default.
- W4281388542 cites W2988494205 @default.
- W4281388542 cites W2993908729 @default.
- W4281388542 cites W3001529746 @default.
- W4281388542 cites W3045057028 @default.
- W4281388542 cites W3084026593 @default.
- W4281388542 cites W3085040687 @default.
- W4281388542 cites W4224987347 @default.
- W4281388542 cites W756650447 @default.
- W4281388542 doi "https://doi.org/10.1016/j.colsurfb.2022.112590" @default.
- W4281388542 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35660744" @default.
- W4281388542 hasPublicationYear "2022" @default.
- W4281388542 type Work @default.
- W4281388542 citedByCount "3" @default.
- W4281388542 countsByYear W42813885422022 @default.
- W4281388542 countsByYear W42813885422023 @default.
- W4281388542 crossrefType "journal-article" @default.
- W4281388542 hasAuthorship W4281388542A5021592265 @default.
- W4281388542 hasAuthorship W4281388542A5023489689 @default.
- W4281388542 hasAuthorship W4281388542A5053551404 @default.
- W4281388542 hasAuthorship W4281388542A5060247750 @default.
- W4281388542 hasConcept C11268172 @default.
- W4281388542 hasConcept C15920480 @default.
- W4281388542 hasConcept C178790620 @default.
- W4281388542 hasConcept C184651966 @default.
- W4281388542 hasConcept C185592680 @default.
- W4281388542 hasConcept C203014093 @default.
- W4281388542 hasConcept C2776914184 @default.
- W4281388542 hasConcept C2779444094 @default.
- W4281388542 hasConcept C2779944601 @default.
- W4281388542 hasConcept C521977710 @default.
- W4281388542 hasConcept C67407626 @default.
- W4281388542 hasConcept C71924100 @default.
- W4281388542 hasConcept C98274493 @default.
- W4281388542 hasConceptScore W4281388542C11268172 @default.
- W4281388542 hasConceptScore W4281388542C15920480 @default.
- W4281388542 hasConceptScore W4281388542C178790620 @default.
- W4281388542 hasConceptScore W4281388542C184651966 @default.
- W4281388542 hasConceptScore W4281388542C185592680 @default.
- W4281388542 hasConceptScore W4281388542C203014093 @default.
- W4281388542 hasConceptScore W4281388542C2776914184 @default.
- W4281388542 hasConceptScore W4281388542C2779444094 @default.
- W4281388542 hasConceptScore W4281388542C2779944601 @default.
- W4281388542 hasConceptScore W4281388542C521977710 @default.
- W4281388542 hasConceptScore W4281388542C67407626 @default.