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- W4281391940 abstract "Epithelial ovarian cancer has the highest mortality among all gynecological malignancies. The main reasons for high mortality are late diagnosis and development of resistance to chemotherapy. Resistance to chemotherapeutic drugs can result from altered expression of drug-resistance genes regulated by miRNA. The main goal of our study was to detect differences in miRNA expression levels in two doxorubicin (DOX)- and two topotecan (TOP)-resistant variants of the A2780 drug-sensitive ovarian cancer cell line by miRNA microarray. The next aim was to recognize miRNAs as factors responsible for the regulation of drug-resistance genes. We observed altered expression of 28 miRNA that may be related to drug resistance. The upregulation of miR-125b-5p and miR-935 and downregulation of miR-218-5p was observed in both DOX-resistant cell lines. In both TOP-resistant cell lines, we noted the overexpression of miR-99a-5p, miR-100-5p, miR-125b-5p, and miR-125b-2-3p and decreased expression of miR-551b-3p, miR-551b-5p, and miR-383-5p. Analysis of the targets suggested that expression of important drug-resistant genes such as the collagen type I alpha 2 chain (COL1A2), protein Tyrosine Phosphatase Receptor Type K (PTPRK), receptor tyrosine kinase-EPHA7, Roundabout Guidance Receptor 2 (ROBO2), myristoylated alanine-rich C-kinase substrate (MARCK), and the ATP-binding cassette subfamily G member 2 (ABCG2) can be regulated by miRNA." @default.
- W4281391940 created "2022-05-25" @default.
- W4281391940 creator A5017288293 @default.
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- W4281391940 date "2022-05-23" @default.
- W4281391940 modified "2023-09-30" @default.
- W4281391940 title "The Profile of MicroRNA Expression and Potential Role in the Regulation of Drug-Resistant Genes in Doxorubicin and Topotecan Resistant Ovarian Cancer Cell Lines" @default.
- W4281391940 cites W1493801922 @default.
- W4281391940 cites W1497664019 @default.
- W4281391940 cites W1543790510 @default.
- W4281391940 cites W1619802440 @default.
- W4281391940 cites W1856825717 @default.
- W4281391940 cites W1871475547 @default.
- W4281391940 cites W1897701706 @default.
- W4281391940 cites W1979338838 @default.
- W4281391940 cites W1984556500 @default.
- W4281391940 cites W1989494625 @default.
- W4281391940 cites W1990575167 @default.
- W4281391940 cites W1996474536 @default.
- W4281391940 cites W1996963134 @default.
- W4281391940 cites W2002906517 @default.
- W4281391940 cites W2009031504 @default.
- W4281391940 cites W2015000379 @default.
- W4281391940 cites W2026570544 @default.
- W4281391940 cites W2031315000 @default.
- W4281391940 cites W2034266037 @default.
- W4281391940 cites W2039448581 @default.
- W4281391940 cites W2044421413 @default.
- W4281391940 cites W2045919693 @default.
- W4281391940 cites W2049264404 @default.
- W4281391940 cites W2054324141 @default.
- W4281391940 cites W2055757796 @default.
- W4281391940 cites W2056772956 @default.
- W4281391940 cites W2058073053 @default.
- W4281391940 cites W2060074160 @default.
- W4281391940 cites W2065949950 @default.
- W4281391940 cites W2068577449 @default.
- W4281391940 cites W2079148941 @default.
- W4281391940 cites W2090736171 @default.
- W4281391940 cites W2098038647 @default.
- W4281391940 cites W2107457010 @default.
- W4281391940 cites W2108349673 @default.
- W4281391940 cites W2116634113 @default.
- W4281391940 cites W2121311423 @default.
- W4281391940 cites W2133506440 @default.
- W4281391940 cites W2138664009 @default.
- W4281391940 cites W2141048775 @default.
- W4281391940 cites W2145161668 @default.
- W4281391940 cites W2146512944 @default.
- W4281391940 cites W2151050516 @default.
- W4281391940 cites W2154711074 @default.
- W4281391940 cites W2164194749 @default.
- W4281391940 cites W2166657167 @default.
- W4281391940 cites W2168230240 @default.
- W4281391940 cites W2204768989 @default.
- W4281391940 cites W2308408790 @default.
- W4281391940 cites W2402411190 @default.
- W4281391940 cites W2475148876 @default.
- W4281391940 cites W2523410070 @default.
- W4281391940 cites W2529607059 @default.
- W4281391940 cites W2533526916 @default.
- W4281391940 cites W2550157647 @default.
- W4281391940 cites W2555949056 @default.
- W4281391940 cites W2564304225 @default.
- W4281391940 cites W2568859793 @default.
- W4281391940 cites W2582671577 @default.
- W4281391940 cites W2606990581 @default.
- W4281391940 cites W2608708957 @default.
- W4281391940 cites W2618927519 @default.
- W4281391940 cites W2635415917 @default.
- W4281391940 cites W2639815295 @default.
- W4281391940 cites W2678800848 @default.
- W4281391940 cites W2734973828 @default.
- W4281391940 cites W2744855162 @default.
- W4281391940 cites W2756276148 @default.
- W4281391940 cites W2760780323 @default.
- W4281391940 cites W2764211476 @default.
- W4281391940 cites W2765718849 @default.
- W4281391940 cites W2781525129 @default.
- W4281391940 cites W2805396618 @default.
- W4281391940 cites W282221905 @default.
- W4281391940 cites W2884859060 @default.
- W4281391940 cites W2887083804 @default.
- W4281391940 cites W2889646458 @default.
- W4281391940 cites W2893643118 @default.
- W4281391940 cites W2899277408 @default.
- W4281391940 cites W2900268381 @default.
- W4281391940 cites W2917889989 @default.
- W4281391940 cites W2934507233 @default.
- W4281391940 cites W2941642329 @default.
- W4281391940 cites W2951421958 @default.
- W4281391940 cites W2963142917 @default.
- W4281391940 cites W2963389795 @default.
- W4281391940 cites W2963611279 @default.