Matches in SemOpenAlex for { <https://semopenalex.org/work/W4281394077> ?p ?o ?g. }
Showing items 1 to 71 of
71
with 100 items per page.
- W4281394077 abstract "Abstract Purpose: The aim of the present work was to analyse and identify differentially expressed miRNAs in Bulgarian patients with non-functioning pituitary adenomas (NFPA). The relationship between deregulated miRNAs and tumor size, invasiveness, and recurrence was determined. Methods: Twenty patients with NFPAs were selected and fresh pituitary tumor tissues were collected. RNA containing miRNAs were isolated using miRNAeasy mini kit and analysed with LNA miRNA Cancer Focus PCR Panel (Qiagen) by quantitative real-time PCR. Results: Three miRNAs (miR-210-3p, miR-149-3p and miR-29b-3p) were deregulated in invasive compared to non-invasive NFPAs. Differential expression of 4-miRNA signature - miRNA-17, miR-19, miR-106a and miR-20 was informative as a recurrence biomarker. ROC analysis showed that the selected miRNAs could be used as potential biomarkers for the diagnosis, prognosis and therapy monitoring of NFPAs. Conclusion: In this pilot study, we selected a unique miRNA expression profile correlating with NFPA invasiveness and recurrence. Moreover, some of the selected miRNAs are reported for the first time in patients with NFPAs and might elucidate the molecular mechanisms involved in pituitary pathogenesis. The selected miRNAs showed a promising biomarker potential and could be studied for future miRNAs-based anti-NFPAs therapy." @default.
- W4281394077 created "2022-05-25" @default.
- W4281394077 creator A5007857396 @default.
- W4281394077 creator A5010349320 @default.
- W4281394077 creator A5038077497 @default.
- W4281394077 creator A5039611720 @default.
- W4281394077 creator A5059242089 @default.
- W4281394077 creator A5063014993 @default.
- W4281394077 creator A5065697805 @default.
- W4281394077 creator A5071506733 @default.
- W4281394077 creator A5082642291 @default.
- W4281394077 creator A5089494990 @default.
- W4281394077 date "2022-05-23" @default.
- W4281394077 modified "2023-09-26" @default.
- W4281394077 title "MiRNA signatures related to invasiveness and recurrence in patients with non-functioning pituitary adenomas" @default.
- W4281394077 doi "https://doi.org/10.21203/rs.3.rs-1656363/v1" @default.
- W4281394077 hasPublicationYear "2022" @default.
- W4281394077 type Work @default.
- W4281394077 citedByCount "0" @default.
- W4281394077 crossrefType "posted-content" @default.
- W4281394077 hasAuthorship W4281394077A5007857396 @default.
- W4281394077 hasAuthorship W4281394077A5010349320 @default.
- W4281394077 hasAuthorship W4281394077A5038077497 @default.
- W4281394077 hasAuthorship W4281394077A5039611720 @default.
- W4281394077 hasAuthorship W4281394077A5059242089 @default.
- W4281394077 hasAuthorship W4281394077A5063014993 @default.
- W4281394077 hasAuthorship W4281394077A5065697805 @default.
- W4281394077 hasAuthorship W4281394077A5071506733 @default.
- W4281394077 hasAuthorship W4281394077A5082642291 @default.
- W4281394077 hasAuthorship W4281394077A5089494990 @default.
- W4281394077 hasBestOaLocation W42813940771 @default.
- W4281394077 hasConcept C104317684 @default.
- W4281394077 hasConcept C121608353 @default.
- W4281394077 hasConcept C126322002 @default.
- W4281394077 hasConcept C143998085 @default.
- W4281394077 hasConcept C145059251 @default.
- W4281394077 hasConcept C2780942790 @default.
- W4281394077 hasConcept C2781197716 @default.
- W4281394077 hasConcept C502942594 @default.
- W4281394077 hasConcept C54355233 @default.
- W4281394077 hasConcept C60644358 @default.
- W4281394077 hasConcept C71924100 @default.
- W4281394077 hasConcept C86803240 @default.
- W4281394077 hasConceptScore W4281394077C104317684 @default.
- W4281394077 hasConceptScore W4281394077C121608353 @default.
- W4281394077 hasConceptScore W4281394077C126322002 @default.
- W4281394077 hasConceptScore W4281394077C143998085 @default.
- W4281394077 hasConceptScore W4281394077C145059251 @default.
- W4281394077 hasConceptScore W4281394077C2780942790 @default.
- W4281394077 hasConceptScore W4281394077C2781197716 @default.
- W4281394077 hasConceptScore W4281394077C502942594 @default.
- W4281394077 hasConceptScore W4281394077C54355233 @default.
- W4281394077 hasConceptScore W4281394077C60644358 @default.
- W4281394077 hasConceptScore W4281394077C71924100 @default.
- W4281394077 hasConceptScore W4281394077C86803240 @default.
- W4281394077 hasLocation W42813940771 @default.
- W4281394077 hasOpenAccess W4281394077 @default.
- W4281394077 hasPrimaryLocation W42813940771 @default.
- W4281394077 hasRelatedWork W1978086123 @default.
- W4281394077 hasRelatedWork W2052277078 @default.
- W4281394077 hasRelatedWork W2128964826 @default.
- W4281394077 hasRelatedWork W2238101020 @default.
- W4281394077 hasRelatedWork W2381017185 @default.
- W4281394077 hasRelatedWork W2473914314 @default.
- W4281394077 hasRelatedWork W2896772915 @default.
- W4281394077 hasRelatedWork W2984941165 @default.
- W4281394077 hasRelatedWork W3012974675 @default.
- W4281394077 hasRelatedWork W3148328529 @default.
- W4281394077 isParatext "false" @default.
- W4281394077 isRetracted "false" @default.
- W4281394077 workType "article" @default.