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- W4281394185 abstract "Graft-versus-host disease (GvHD) is a potentially life-threatening and commonly encountered event of allogeneic haematopoietic stem cell transplantation. Here, we present a young adult male with primary refractory Hodgkin's lymphoma who received a transplant and developed cutaneous GvHD after donor lymphocyte infusion, which was managed with cyclosporine and steroids. However, while the patient was under immunosuppressive treatment, diffuse confluent whitish patches on the patient's tongue were observed. A biopsy of the tongue lesions revealed lichenoid, hyperkeratotic tissue changes and intraepithelial T-cell infiltration consistent with chronic GvHD. He was treated with mycophenolate mofetil for 6 months with minimal improvement. Janus-associated kinase inhibitor (ruxolitinib) treatment was commenced, with complete resolution of the tongue lesions and treatment discontinuation 5 months later. Currently, 5 years after allogeneic transplantation, he is in remission and does not need immunosuppressive therapy." @default.
- W4281394185 created "2022-05-25" @default.
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- W4281394185 date "2022-05-01" @default.
- W4281394185 modified "2023-10-16" @default.
- W4281394185 title "Tongue graft-versus-host disease: remission with ruxolitinib" @default.
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- W4281394185 doi "https://doi.org/10.1136/bcr-2021-247888" @default.
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