FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4281399055> ?p ?o ?g. }

• W4281399055 abstract "Abstract Background Apelin is a new adipokine that is secreted by adipocytes, and is associated with insulin resistance (IR), inflammation, and obesity. This study was designed to investigate the role of apelin in type 2 diabetes mellitus (T2DM) patients with mild cognitive impairment (MCI). Methods A total of 235 patients with T2DM were included. The cognitive function of patients was evaluated using Montreal Cognitive Assessment (MoCA) tool, then patients were divided into MCI group and non-MCI group according to the MoCA score. Blood sample was analyzed for the level of apelin by enzyme-linked immunosorbent assay (ELISA). Results The MCI group ( n = 73) presented lower serum apelin levels compared with the patients with normal cognitive function ( P < 0.001). Apelin levels showed significantly negative correlation with diabetes duration, triglyceride (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C, creatinine and high sensitivity C-reactive protein (hs-CRP), and positive correlation with high-density lipoprotein cholesterol (HDL-C) and brain-derived neurotrophic factor (BDNF). Multivariable logistic regression analysis indicated that serum apelin (OR = 0.304, 95%CI: 0.104–0.886, P = 0.029), as well as education levels, diabetes duration, cardiovascular disease, serum HbA1c, HDL-C, creatinine, and BDNF, were independent risk factors of MCI in patients with T2DM. Conclusions Serum apelin level is reduced in T2DM patients with MCI. Apelin might has protective effect against cognitive impairment and serve as a serum biomarker of T2DM." @default.
• W4281399055 created "2022-05-25" @default.
• W4281399055 creator A5010091089 @default.
• W4281399055 creator A5061079113 @default.
• W4281399055 creator A5069873272 @default.
• W4281399055 date "2022-05-24" @default.
• W4281399055 modified "2023-10-02" @default.
• W4281399055 title "Low serum apelin levels are associated with mild cognitive impairment in Type 2 diabetic patients" @default.
• W4281399055 cites W1593393815 @default.
• W4281399055 cites W1972559234 @default.
• W4281399055 cites W1972982304 @default.
• W4281399055 cites W1981498277 @default.
• W4281399055 cites W2016437556 @default.
• W4281399055 cites W2046949772 @default.
• W4281399055 cites W2048554459 @default.
• W4281399055 cites W2058135511 @default.
• W4281399055 cites W2091143569 @default.
• W4281399055 cites W2119946747 @default.
• W4281399055 cites W2124386285 @default.
• W4281399055 cites W2129497119 @default.
• W4281399055 cites W2130386048 @default.
• W4281399055 cites W2134293572 @default.
• W4281399055 cites W2152509794 @default.
• W4281399055 cites W2159122349 @default.
• W4281399055 cites W2165758561 @default.
• W4281399055 cites W2478469703 @default.
• W4281399055 cites W2611378271 @default.
• W4281399055 cites W2760802040 @default.
• W4281399055 cites W2797109583 @default.
• W4281399055 cites W2900953724 @default.
• W4281399055 cites W2923025380 @default.
• W4281399055 cites W2991754741 @default.
• W4281399055 cites W3002671551 @default.
• W4281399055 cites W3138790345 @default.
• W4281399055 cites W3150661421 @default.
• W4281399055 cites W3211486568 @default.
• W4281399055 cites W38444032 @default.
• W4281399055 cites W4211200327 @default.
• W4281399055 cites W97680146 @default.
• W4281399055 doi "https://doi.org/10.1186/s12902-022-01051-1" @default.
• W4281399055 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35610700" @default.
• W4281399055 hasPublicationYear "2022" @default.
• W4281399055 type Work @default.
• W4281399055 citedByCount "1" @default.
• W4281399055 countsByYear W42813990552023 @default.
• W4281399055 crossrefType "journal-article" @default.
• W4281399055 hasAuthorship W4281399055A5010091089 @default.
• W4281399055 hasAuthorship W4281399055A5061079113 @default.
• W4281399055 hasAuthorship W4281399055A5069873272 @default.
• W4281399055 hasBestOaLocation W42813990551 @default.
• W4281399055 hasConcept C126322002 @default.
• W4281399055 hasConcept C134018914 @default.
• W4281399055 hasConcept C159641895 @default.
• W4281399055 hasConcept C170493617 @default.
• W4281399055 hasConcept C185592680 @default.
• W4281399055 hasConcept C194832188 @default.
• W4281399055 hasConcept C2776632958 @default.
• W4281399055 hasConcept C2777180221 @default.
• W4281399055 hasConcept C2777391703 @default.
• W4281399055 hasConcept C2778163477 @default.
• W4281399055 hasConcept C2778270857 @default.
• W4281399055 hasConcept C2778913445 @default.
• W4281399055 hasConcept C2779134260 @default.
• W4281399055 hasConcept C2779483572 @default.
• W4281399055 hasConcept C2779546753 @default.
• W4281399055 hasConcept C2780306776 @default.
• W4281399055 hasConcept C2781197716 @default.
• W4281399055 hasConcept C2910068830 @default.
• W4281399055 hasConcept C511355011 @default.
• W4281399055 hasConcept C55493867 @default.
• W4281399055 hasConcept C555293320 @default.
• W4281399055 hasConcept C71924100 @default.
• W4281399055 hasConcept C90924648 @default.
• W4281399055 hasConceptScore W4281399055C126322002 @default.
• W4281399055 hasConceptScore W4281399055C134018914 @default.
• W4281399055 hasConceptScore W4281399055C159641895 @default.
• W4281399055 hasConceptScore W4281399055C170493617 @default.
• W4281399055 hasConceptScore W4281399055C185592680 @default.
• W4281399055 hasConceptScore W4281399055C194832188 @default.
• W4281399055 hasConceptScore W4281399055C2776632958 @default.
• W4281399055 hasConceptScore W4281399055C2777180221 @default.
• W4281399055 hasConceptScore W4281399055C2777391703 @default.
• W4281399055 hasConceptScore W4281399055C2778163477 @default.
• W4281399055 hasConceptScore W4281399055C2778270857 @default.
• W4281399055 hasConceptScore W4281399055C2778913445 @default.
• W4281399055 hasConceptScore W4281399055C2779134260 @default.
• W4281399055 hasConceptScore W4281399055C2779483572 @default.
• W4281399055 hasConceptScore W4281399055C2779546753 @default.
• W4281399055 hasConceptScore W4281399055C2780306776 @default.
• W4281399055 hasConceptScore W4281399055C2781197716 @default.
• W4281399055 hasConceptScore W4281399055C2910068830 @default.
• W4281399055 hasConceptScore W4281399055C511355011 @default.
• W4281399055 hasConceptScore W4281399055C55493867 @default.
• W4281399055 hasConceptScore W4281399055C555293320 @default.
• W4281399055 hasConceptScore W4281399055C71924100 @default.
• W4281399055 hasConceptScore W4281399055C90924648 @default.
• W4281399055 hasIssue "1" @default.
• W4281399055 hasLocation W42813990551 @default.
• W4281399055 hasLocation W42813990552 @default.
• W4281399055 hasLocation W42813990553 @default.

• next