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- W4281477144 endingPage "2608" @default.
- W4281477144 startingPage "2608" @default.
- W4281477144 abstract "Based on the enhanced knowledge on the tumor microenvironment (TME), a more comprehensive treatment landscape for targeting the TME has emerged. This microenvironment provides multiple therapeutic targets due to its diverse characteristics, leading to numerous TME-targeted strategies. With multifaced activities targeting tumors and the TME, vitamin C is renown as a promising candidate for combination therapy. In this review, we present new advances in how vitamin C reshapes the TME in the immune, hypoxic, metabolic, acidic, neurological, mechanical, and microbial dimensions. These findings will open new possibilities for multiple therapeutic avenues in the fight against cancer. We also review the available preclinical and clinical evidence of vitamin C combined with established therapies, highlighting vitamin C as an adjuvant that can be exploited for novel therapeutics. Finally, we discuss unresolved questions and directions that merit further investigation." @default.
- W4281477144 created "2022-05-26" @default.
- W4281477144 creator A5028645155 @default.
- W4281477144 creator A5035342344 @default.
- W4281477144 creator A5042129062 @default.
- W4281477144 creator A5064248970 @default.
- W4281477144 date "2022-05-25" @default.
- W4281477144 modified "2023-10-13" @default.
- W4281477144 title "Repurposing Vitamin C for Cancer Treatment: Focus on Targeting the Tumor Microenvironment" @default.
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