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- W4281477686 abstract "Significance This study addresses how the cerebral cortex is partitioned into specialized areas during development. Although both early embryonic patterning and postnatal synaptic input from sensory thalamic nuclei are known to be critical, early roles of thalamic axons in area-specific regulation of cortical neurogenesis are poorly understood. We examined this by developing a genetic mouse model in which thalamocortical projections fail to properly form during embryogenesis, and found these axons are required not only for an enhanced production of superficial layer neurons but also for promoting the layer 4 cell fate, a hallmark of the primary sensory cortex. These findings provide a mechanism by which thalamocortical axons complement the intrinsic programs of neurogenesis and early fate specification." @default.
- W4281477686 created "2022-05-26" @default.
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- W4281477686 date "2022-05-25" @default.
- W4281477686 modified "2023-09-27" @default.
- W4281477686 title "Thalamocortical axons regulate neurogenesis and laminar fates in the early sensory cortex" @default.
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- W4281477686 doi "https://doi.org/10.1073/pnas.2201355119" @default.
- W4281477686 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35613048" @default.
- W4281477686 hasPublicationYear "2022" @default.
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