Matches in SemOpenAlex for { <https://semopenalex.org/work/W4281484453> ?p ?o ?g. }
- W4281484453 endingPage "5915" @default.
- W4281484453 startingPage "5915" @default.
- W4281484453 abstract "Cerebral small vessel disease (CSVD) is the second most common cause of stroke and a major contributor to dementia. Manifestations of CSVD include cerebral microbleeds, intracerebral hemorrhages (ICH), lacunar infarcts, white matter hyperintensities (WMH) and enlarged perivascular spaces. Chronic hypertensive models have been found to reproduce most key features of the disease. Nevertheless, no animal models have been identified to reflect all different aspects of the human disease. Here, we described a novel model for CSVD using salt-sensitive ‘Sabra’ hypertension-prone rats (SBH/y), which display chronic hypertension and enhanced peripheral oxidative stress. SBH/y rats were either administered deoxycorticosteroid acetate (DOCA) (referred to as SBH/y-DOCA rats) or sham-operated and provided with 1% NaCl in drinking water. Rats underwent neurological assessment and behavioral testing, followed by ex vivo MRI and biochemical and histological analyses. SBH/y-DOCA rats show a neurological decline and cognitive impairment and present multiple cerebrovascular pathologies associated with CSVD, such as ICH, lacunes, enlarged perivascular spaces, blood vessel stenosis, BBB permeability and inflammation. Remarkably, SBH/y-DOCA rats show severe white matter pathology as well as WMH, which are rarely reported in commonly used models. Our model may serve as a novel platform for further understanding the mechanisms underlying CSVD and for testing novel therapeutics." @default.
- W4281484453 created "2022-05-26" @default.
- W4281484453 creator A5001703565 @default.
- W4281484453 creator A5009838266 @default.
- W4281484453 creator A5026000958 @default.
- W4281484453 creator A5032136798 @default.
- W4281484453 creator A5048367461 @default.
- W4281484453 creator A5056120548 @default.
- W4281484453 creator A5060279037 @default.
- W4281484453 creator A5060450468 @default.
- W4281484453 creator A5074975266 @default.
- W4281484453 date "2022-05-25" @default.
- W4281484453 modified "2023-10-16" @default.
- W4281484453 title "A Novel Rodent Model of Hypertensive Cerebral Small Vessel Disease with White Matter Hyperintensities and Peripheral Oxidative Stress" @default.
- W4281484453 cites W1969700660 @default.
- W4281484453 cites W1969898963 @default.
- W4281484453 cites W1972911854 @default.
- W4281484453 cites W1974155908 @default.
- W4281484453 cites W2002088255 @default.
- W4281484453 cites W2005754674 @default.
- W4281484453 cites W2026255271 @default.
- W4281484453 cites W2034833513 @default.
- W4281484453 cites W2042783882 @default.
- W4281484453 cites W2062445975 @default.
- W4281484453 cites W2086036056 @default.
- W4281484453 cites W2090240743 @default.
- W4281484453 cites W2092521188 @default.
- W4281484453 cites W2104026222 @default.
- W4281484453 cites W2104901197 @default.
- W4281484453 cites W2139072436 @default.
- W4281484453 cites W2140621953 @default.
- W4281484453 cites W2141352225 @default.
- W4281484453 cites W2143060791 @default.
- W4281484453 cites W2149240296 @default.
- W4281484453 cites W2300572963 @default.
- W4281484453 cites W2306343806 @default.
- W4281484453 cites W2395176267 @default.
- W4281484453 cites W2622764401 @default.
- W4281484453 cites W2739915050 @default.
- W4281484453 cites W2769642662 @default.
- W4281484453 cites W2892168042 @default.
- W4281484453 cites W2894776090 @default.
- W4281484453 cites W2903460914 @default.
- W4281484453 cites W2969568291 @default.
- W4281484453 cites W2982149592 @default.
- W4281484453 cites W3008363131 @default.
- W4281484453 cites W3021490873 @default.
- W4281484453 cites W3025713031 @default.
- W4281484453 cites W3026093678 @default.
- W4281484453 cites W3038948962 @default.
- W4281484453 cites W3045679766 @default.
- W4281484453 cites W3099660684 @default.
- W4281484453 cites W3117696160 @default.
- W4281484453 cites W3128843941 @default.
- W4281484453 cites W3129351820 @default.
- W4281484453 cites W3159696109 @default.
- W4281484453 cites W3196253719 @default.
- W4281484453 cites W3198642554 @default.
- W4281484453 cites W3215963094 @default.
- W4281484453 cites W4200409956 @default.
- W4281484453 cites W4210270872 @default.
- W4281484453 cites W4235046030 @default.
- W4281484453 doi "https://doi.org/10.3390/ijms23115915" @default.
- W4281484453 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35682594" @default.
- W4281484453 hasPublicationYear "2022" @default.
- W4281484453 type Work @default.
- W4281484453 citedByCount "3" @default.
- W4281484453 countsByYear W42814844532022 @default.
- W4281484453 countsByYear W42814844532023 @default.
- W4281484453 crossrefType "journal-article" @default.
- W4281484453 hasAuthorship W4281484453A5001703565 @default.
- W4281484453 hasAuthorship W4281484453A5009838266 @default.
- W4281484453 hasAuthorship W4281484453A5026000958 @default.
- W4281484453 hasAuthorship W4281484453A5032136798 @default.
- W4281484453 hasAuthorship W4281484453A5048367461 @default.
- W4281484453 hasAuthorship W4281484453A5056120548 @default.
- W4281484453 hasAuthorship W4281484453A5060279037 @default.
- W4281484453 hasAuthorship W4281484453A5060450468 @default.
- W4281484453 hasAuthorship W4281484453A5074975266 @default.
- W4281484453 hasBestOaLocation W42814844531 @default.
- W4281484453 hasConcept C126322002 @default.
- W4281484453 hasConcept C126838900 @default.
- W4281484453 hasConcept C127413603 @default.
- W4281484453 hasConcept C142724271 @default.
- W4281484453 hasConcept C143409427 @default.
- W4281484453 hasConcept C146638467 @default.
- W4281484453 hasConcept C150903083 @default.
- W4281484453 hasConcept C164705383 @default.
- W4281484453 hasConcept C207001950 @default.
- W4281484453 hasConcept C26291073 @default.
- W4281484453 hasConcept C2776151105 @default.
- W4281484453 hasConcept C2776191500 @default.
- W4281484453 hasConcept C2776914184 @default.
- W4281484453 hasConcept C2777799939 @default.
- W4281484453 hasConcept C2778402981 @default.
- W4281484453 hasConcept C2779134260 @default.
- W4281484453 hasConcept C2779285336 @default.
- W4281484453 hasConcept C2779483572 @default.