Matches in SemOpenAlex for { <https://semopenalex.org/work/W4281485160> ?p ?o ?g. }
- W4281485160 abstract "Diabetic nephropathy (DN) and diabetic retinopathy (DR) are microvascular complications of diabetes. Microvascular endothelial cells are thought to be the major targets of hyperglycemic injury. In diabetic microvasculature, the intracellular hyperglycemia causes damages to the vascular endothelium, via multiple pathophysiological process consist of inflammation, endothelial cell crosstalk with podocytes/pericytes and exosomes. In addition, DN and DR diseases development are involved in several critical regulators including the cell adhesion molecules (CAMs), the vascular endothelial growth factor (VEGF) family and the Notch signal. The present review attempts to gain a deeper understanding of the pathogenesis complexities underlying the endothelial dysfunction in diabetes diabetic and retinopathy, contributing to the development of new mechanistic therapeutic strategies against diabetes-induced microvascular endothelial dysfunction." @default.
- W4281485160 created "2022-05-26" @default.
- W4281485160 creator A5032539923 @default.
- W4281485160 creator A5070792980 @default.
- W4281485160 date "2022-05-25" @default.
- W4281485160 modified "2023-10-14" @default.
- W4281485160 title "Mechanistic Pathogenesis of Endothelial Dysfunction in Diabetic Nephropathy and Retinopathy" @default.
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