FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4281486514> ?p ?o ?g. }

• W4281486514 abstract "Cyclosporine A (CsA) is an immunosuppressive drug that suppresses T cell responses and is broadly used in transplantation. Its immunosuppressive action is closely linked to its binding of cyclophilin A (CypA), which widely distributed in different cell types. CsA also regulates the functions of innate immune cells, but the mechanism remains elusive. Here, we investigate the role of CsA in regulating macrophages polarization in influenza A virus-infected mice and mouse bone marrow-derived macrophages. CsA downregulates pro-inflammatory cytokines expression and upregulates anti-inflammatory cytokines expression. Mechanically, CsA decreases the polarization of macrophages into pro-inflammatory M1 phenotype and increases the polarization of macrophages into anti-inflammatory M2 phenotype. Further studies show that CsA regulates macrophages polarization-associated IFN-γ/STAT1 and IL-4/STAT6 signaling pathways. Meanwhile, all these roles of CsA are eliminated when CypA is absent, suggesting that CsA regulates macrophages polarization and inflammatory responses depend on its binding to CypA. Collectively, these results reveal a crucial mechanism of CsA in attenuating IAV-induced inflammatory responses by a switch in macrophages polarization." @default.
• W4281486514 created "2022-05-26" @default.
• W4281486514 creator A5008726894 @default.
• W4281486514 creator A5027468009 @default.
• W4281486514 creator A5031895402 @default.
• W4281486514 creator A5038776482 @default.
• W4281486514 creator A5061425549 @default.
• W4281486514 creator A5062411566 @default.
• W4281486514 creator A5064323494 @default.
• W4281486514 creator A5066463484 @default.
• W4281486514 date "2022-05-25" @default.
• W4281486514 modified "2023-09-25" @default.
• W4281486514 title "Cyclosporine A Regulates Influenza A Virus-induced Macrophages Polarization and Inflammatory Responses by Targeting Cyclophilin A" @default.
• W4281486514 cites W1571758492 @default.
• W4281486514 cites W1853714779 @default.
• W4281486514 cites W1972528075 @default.
• W4281486514 cites W1984754431 @default.
• W4281486514 cites W1992974015 @default.
• W4281486514 cites W1997733646 @default.
• W4281486514 cites W2001484558 @default.
• W4281486514 cites W2011196153 @default.
• W4281486514 cites W2019689527 @default.
• W4281486514 cites W2022305597 @default.
• W4281486514 cites W2032639324 @default.
• W4281486514 cites W2039183048 @default.
• W4281486514 cites W2039782308 @default.
• W4281486514 cites W2043216363 @default.
• W4281486514 cites W2049194844 @default.
• W4281486514 cites W2065210647 @default.
• W4281486514 cites W2067545345 @default.
• W4281486514 cites W2070855360 @default.
• W4281486514 cites W2074150439 @default.
• W4281486514 cites W2084231086 @default.
• W4281486514 cites W2089047070 @default.
• W4281486514 cites W2089850443 @default.
• W4281486514 cites W2098867116 @default.
• W4281486514 cites W2106772621 @default.
• W4281486514 cites W2124881273 @default.
• W4281486514 cites W2130594874 @default.
• W4281486514 cites W2133106116 @default.
• W4281486514 cites W2147682506 @default.
• W4281486514 cites W2152899800 @default.
• W4281486514 cites W2159348270 @default.
• W4281486514 cites W2162080474 @default.
• W4281486514 cites W2170984368 @default.
• W4281486514 cites W2406500641 @default.
• W4281486514 cites W2504697643 @default.
• W4281486514 cites W2576121176 @default.
• W4281486514 cites W2577043529 @default.
• W4281486514 cites W2603052728 @default.
• W4281486514 cites W2604481149 @default.
• W4281486514 cites W2622279238 @default.
• W4281486514 cites W2782221410 @default.
• W4281486514 cites W2936783167 @default.
• W4281486514 cites W2953471843 @default.
• W4281486514 cites W2963519960 @default.
• W4281486514 cites W3007754709 @default.
• W4281486514 cites W3126907409 @default.
• W4281486514 cites W3161390471 @default.
• W4281486514 doi "https://doi.org/10.3389/fimmu.2022.861292" @default.
• W4281486514 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35693825" @default.
• W4281486514 hasPublicationYear "2022" @default.
• W4281486514 type Work @default.
• W4281486514 citedByCount "0" @default.
• W4281486514 crossrefType "journal-article" @default.
• W4281486514 hasAuthorship W4281486514A5008726894 @default.
• W4281486514 hasAuthorship W4281486514A5027468009 @default.
• W4281486514 hasAuthorship W4281486514A5031895402 @default.
• W4281486514 hasAuthorship W4281486514A5038776482 @default.
• W4281486514 hasAuthorship W4281486514A5061425549 @default.
• W4281486514 hasAuthorship W4281486514A5062411566 @default.
• W4281486514 hasAuthorship W4281486514A5064323494 @default.
• W4281486514 hasAuthorship W4281486514A5066463484 @default.
• W4281486514 hasBestOaLocation W42814865141 @default.
• W4281486514 hasConcept C136449434 @default.
• W4281486514 hasConcept C153911025 @default.
• W4281486514 hasConcept C185592680 @default.
• W4281486514 hasConcept C202751555 @default.
• W4281486514 hasConcept C203014093 @default.
• W4281486514 hasConcept C2776682551 @default.
• W4281486514 hasConcept C2776914184 @default.
• W4281486514 hasConcept C2779244956 @default.
• W4281486514 hasConcept C2780778672 @default.
• W4281486514 hasConcept C2909439513 @default.
• W4281486514 hasConcept C55493867 @default.
• W4281486514 hasConcept C62478195 @default.
• W4281486514 hasConcept C86803240 @default.
• W4281486514 hasConcept C8891405 @default.
• W4281486514 hasConcept C95444343 @default.
• W4281486514 hasConceptScore W4281486514C136449434 @default.
• W4281486514 hasConceptScore W4281486514C153911025 @default.
• W4281486514 hasConceptScore W4281486514C185592680 @default.
• W4281486514 hasConceptScore W4281486514C202751555 @default.
• W4281486514 hasConceptScore W4281486514C203014093 @default.
• W4281486514 hasConceptScore W4281486514C2776682551 @default.
• W4281486514 hasConceptScore W4281486514C2776914184 @default.
• W4281486514 hasConceptScore W4281486514C2779244956 @default.
• W4281486514 hasConceptScore W4281486514C2780778672 @default.
• W4281486514 hasConceptScore W4281486514C2909439513 @default.
• W4281486514 hasConceptScore W4281486514C55493867 @default.

• next