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• W4281486651 endingPage "2603" @default.
• W4281486651 startingPage "2603" @default.
• W4281486651 abstract "Despite the great success of TNF blockers in the treatment of autoimmune diseases and the identification of TNF as a factor that influences the development of tumors in many ways, the role of TNFR2 in tumor biology and its potential suitability as a therapeutic target in cancer therapy have long been underestimated. This has been fundamentally changed with the identification of TNFR2 as a regulatory T-cell (Treg)-stimulating factor and the general clinical breakthrough of immunotherapeutic approaches. However, considering TNFR2 as a sole immunosuppressive factor in the tumor microenvironment does not go far enough. TNFR2 can also co-stimulate CD8+ T-cells, sensitize some immune and tumor cells to the cytotoxic effects of TNFR1 and/or acts as an oncogene. In view of the wide range of cancer-associated TNFR2 activities, it is not surprising that both antagonists and agonists of TNFR2 are considered for tumor therapy and have indeed shown overwhelming anti-tumor activity in preclinical studies. Based on a brief summary of TNFR2 signaling and the immunoregulatory functions of TNFR2, we discuss here the main preclinical findings and insights gained with TNFR2 agonists and antagonists. In particular, we address the question of which TNFR2-associated molecular and cellular mechanisms underlie the observed anti-tumoral activities of TNFR2 agonists and antagonists." @default.
• W4281486651 created "2022-05-26" @default.
• W4281486651 creator A5022446406 @default.
• W4281486651 creator A5041527718 @default.
• W4281486651 creator A5063483172 @default.
• W4281486651 date "2022-05-25" @default.
• W4281486651 modified "2023-10-14" @default.
• W4281486651 title "Tumor Necrosis Factor Receptor 2 (TNFR2): An Emerging Target in Cancer Therapy" @default.
• W4281486651 cites W1508172388 @default.
• W4281486651 cites W1525794869 @default.
• W4281486651 cites W1557037837 @default.
• W4281486651 cites W1585093254 @default.
• W4281486651 cites W1599910722 @default.
• W4281486651 cites W1767555911 @default.
• W4281486651 cites W1822745879 @default.
• W4281486651 cites W1825962579 @default.
• W4281486651 cites W1851585398 @default.
• W4281486651 cites W1883117256 @default.
• W4281486651 cites W1885103044 @default.
• W4281486651 cites W1912996546 @default.
• W4281486651 cites W1915374685 @default.
• W4281486651 cites W1923875548 @default.
• W4281486651 cites W1945216762 @default.
• W4281486651 cites W1968200608 @default.
• W4281486651 cites W1969070574 @default.
• W4281486651 cites W1971240021 @default.
• W4281486651 cites W1972274031 @default.
• W4281486651 cites W1973680986 @default.
• W4281486651 cites W1978541038 @default.
• W4281486651 cites W1979982965 @default.
• W4281486651 cites W1985082045 @default.
• W4281486651 cites W1990089954 @default.
• W4281486651 cites W1990293928 @default.
• W4281486651 cites W1999625746 @default.
• W4281486651 cites W2004150448 @default.
• W4281486651 cites W2004468702 @default.
• W4281486651 cites W2004895532 @default.
• W4281486651 cites W2011088911 @default.
• W4281486651 cites W2014553274 @default.
• W4281486651 cites W2015348995 @default.
• W4281486651 cites W2016767695 @default.
• W4281486651 cites W2018884000 @default.
• W4281486651 cites W2019217555 @default.
• W4281486651 cites W2022854500 @default.
• W4281486651 cites W2029871546 @default.
• W4281486651 cites W2030612376 @default.
• W4281486651 cites W2036842448 @default.
• W4281486651 cites W2036881989 @default.
• W4281486651 cites W2042872424 @default.
• W4281486651 cites W2046382304 @default.
• W4281486651 cites W2058732867 @default.
• W4281486651 cites W2061045389 @default.
• W4281486651 cites W2063640156 @default.
• W4281486651 cites W2063690467 @default.
• W4281486651 cites W2063779547 @default.
• W4281486651 cites W2064465890 @default.
• W4281486651 cites W2069640685 @default.
• W4281486651 cites W2072136070 @default.
• W4281486651 cites W2072380594 @default.
• W4281486651 cites W2072434094 @default.
• W4281486651 cites W2073310925 @default.
• W4281486651 cites W2074565731 @default.
• W4281486651 cites W2074881372 @default.
• W4281486651 cites W2080558054 @default.
• W4281486651 cites W2081529759 @default.
• W4281486651 cites W2086255604 @default.
• W4281486651 cites W2088619685 @default.
• W4281486651 cites W2089370460 @default.
• W4281486651 cites W2091846487 @default.
• W4281486651 cites W2092377971 @default.
• W4281486651 cites W2100762111 @default.
• W4281486651 cites W2103180268 @default.
• W4281486651 cites W2104294370 @default.
• W4281486651 cites W2105337626 @default.
• W4281486651 cites W2110775306 @default.
• W4281486651 cites W2113715519 @default.
• W4281486651 cites W2113765407 @default.
• W4281486651 cites W2115789412 @default.
• W4281486651 cites W2120951438 @default.
• W4281486651 cites W2123161339 @default.
• W4281486651 cites W2124343538 @default.
• W4281486651 cites W2130025456 @default.
• W4281486651 cites W2134020449 @default.
• W4281486651 cites W2138934663 @default.
• W4281486651 cites W2143719342 @default.
• W4281486651 cites W2144420811 @default.
• W4281486651 cites W2147374892 @default.
• W4281486651 cites W2147522679 @default.
• W4281486651 cites W2148226248 @default.
• W4281486651 cites W2151666328 @default.
• W4281486651 cites W2153045866 @default.
• W4281486651 cites W2155517651 @default.
• W4281486651 cites W2157094981 @default.
• W4281486651 cites W2157200816 @default.
• W4281486651 cites W2157269800 @default.
• W4281486651 cites W2160229573 @default.
• W4281486651 cites W2161053002 @default.
• W4281486651 cites W2162124617 @default.

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