Matches in SemOpenAlex for { <https://semopenalex.org/work/W4281487031> ?p ?o ?g. }
- W4281487031 endingPage "156218" @default.
- W4281487031 startingPage "156218" @default.
- W4281487031 abstract "N, N-dimethylformamide (DMF) is a widely existing harmful environmental pollutant from industrial emission which can threat human health for both occupational and general populations. Epidemiological and experimental studies have indicated liver as the primary target organ of DMF. However, the molecular mechanism under DMF-induced hepatoxicity remains unclear. In the present study, we identified that DMF could induce abnormal autophagy flux in cells. We also showed that DMF-induced mitochondrial dysfunction and lethal mitophagy which further leads to autophagic cell death. Next, miRNA microarray analysis identified miR-92a-1-5p as the most down-regulated miRNA upon DMF exposure. Mechanistically, miR-92a-1-5p regulated mitochondrial function and mitophagy by targeting mitochondrial protein BNIP3L. Exogenous miR-92a-1-5p significantly attenuated DMF-induced mitochondrial dysfunction and mitophagy in vitro and in vivo. Our study highlights the mechanistic link between miRNAs and mitophagy under environmental stress, which provided a new clue for the mitochondrial epigenetics mechanism on environmental toxicant-induced hepatoxicity." @default.
- W4281487031 created "2022-05-26" @default.
- W4281487031 creator A5001825615 @default.
- W4281487031 creator A5002069152 @default.
- W4281487031 creator A5002389534 @default.
- W4281487031 creator A5015282309 @default.
- W4281487031 creator A5015728065 @default.
- W4281487031 creator A5020331004 @default.
- W4281487031 creator A5023219183 @default.
- W4281487031 creator A5027958504 @default.
- W4281487031 creator A5033423299 @default.
- W4281487031 creator A5044388542 @default.
- W4281487031 creator A5082922304 @default.
- W4281487031 date "2022-09-01" @default.
- W4281487031 modified "2023-10-16" @default.
- W4281487031 title "N, N-dimethylformamide exposure induced liver abnormal mitophagy by targeting miR-92a-1-5p-BNIP3L pathway in vivo and vitro" @default.
- W4281487031 cites W1225305973 @default.
- W4281487031 cites W1923149568 @default.
- W4281487031 cites W1970730430 @default.
- W4281487031 cites W1976852494 @default.
- W4281487031 cites W1980054636 @default.
- W4281487031 cites W1989966286 @default.
- W4281487031 cites W1991700908 @default.
- W4281487031 cites W2002530754 @default.
- W4281487031 cites W2012363663 @default.
- W4281487031 cites W2016040396 @default.
- W4281487031 cites W2040080535 @default.
- W4281487031 cites W2061460256 @default.
- W4281487031 cites W2063403801 @default.
- W4281487031 cites W2063597415 @default.
- W4281487031 cites W2070254246 @default.
- W4281487031 cites W2079760714 @default.
- W4281487031 cites W2127440157 @default.
- W4281487031 cites W2138311396 @default.
- W4281487031 cites W2142678743 @default.
- W4281487031 cites W2153029275 @default.
- W4281487031 cites W2158999905 @default.
- W4281487031 cites W2272315791 @default.
- W4281487031 cites W2470284319 @default.
- W4281487031 cites W2481336158 @default.
- W4281487031 cites W2507784547 @default.
- W4281487031 cites W2726754850 @default.
- W4281487031 cites W2772826529 @default.
- W4281487031 cites W2790837380 @default.
- W4281487031 cites W2792500974 @default.
- W4281487031 cites W2795377526 @default.
- W4281487031 cites W2899153893 @default.
- W4281487031 cites W2905264563 @default.
- W4281487031 cites W2905399276 @default.
- W4281487031 cites W2907122465 @default.
- W4281487031 cites W2909927101 @default.
- W4281487031 cites W2914334792 @default.
- W4281487031 cites W2931812640 @default.
- W4281487031 cites W2937346106 @default.
- W4281487031 cites W2938973810 @default.
- W4281487031 cites W2973091969 @default.
- W4281487031 cites W2975837000 @default.
- W4281487031 cites W3003625792 @default.
- W4281487031 cites W3014339066 @default.
- W4281487031 cites W3014792054 @default.
- W4281487031 cites W3030312233 @default.
- W4281487031 cites W3040790371 @default.
- W4281487031 cites W3045060406 @default.
- W4281487031 cites W3052293365 @default.
- W4281487031 cites W3086130565 @default.
- W4281487031 cites W3114087646 @default.
- W4281487031 cites W3125250500 @default.
- W4281487031 cites W3134145257 @default.
- W4281487031 cites W3159572473 @default.
- W4281487031 cites W3173734951 @default.
- W4281487031 doi "https://doi.org/10.1016/j.scitotenv.2022.156218" @default.
- W4281487031 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/35623527" @default.
- W4281487031 hasPublicationYear "2022" @default.
- W4281487031 type Work @default.
- W4281487031 citedByCount "6" @default.
- W4281487031 countsByYear W42814870312022 @default.
- W4281487031 countsByYear W42814870312023 @default.
- W4281487031 crossrefType "journal-article" @default.
- W4281487031 hasAuthorship W4281487031A5001825615 @default.
- W4281487031 hasAuthorship W4281487031A5002069152 @default.
- W4281487031 hasAuthorship W4281487031A5002389534 @default.
- W4281487031 hasAuthorship W4281487031A5015282309 @default.
- W4281487031 hasAuthorship W4281487031A5015728065 @default.
- W4281487031 hasAuthorship W4281487031A5020331004 @default.
- W4281487031 hasAuthorship W4281487031A5023219183 @default.
- W4281487031 hasAuthorship W4281487031A5027958504 @default.
- W4281487031 hasAuthorship W4281487031A5033423299 @default.
- W4281487031 hasAuthorship W4281487031A5044388542 @default.
- W4281487031 hasAuthorship W4281487031A5082922304 @default.
- W4281487031 hasConcept C104317684 @default.
- W4281487031 hasConcept C121332964 @default.
- W4281487031 hasConcept C145059251 @default.
- W4281487031 hasConcept C178790620 @default.
- W4281487031 hasConcept C185592680 @default.
- W4281487031 hasConcept C190283241 @default.
- W4281487031 hasConcept C202751555 @default.
- W4281487031 hasConcept C203522944 @default.
- W4281487031 hasConcept C207001950 @default.